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Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics.
Laryngoscope 2010; 120(11):2203-12L

Abstract

OBJECTIVES/HYPOTHESIS

To examine demographic, histologic, and survival trends of oral cavity and oropharyngeal (OC/OP) squamous cell carcinoma (SCCA) patients over the past 3 decades. To test the hypothesis that decreased histologic differentiation and increased disease-specific survival is related to a decline in smoking rates and an increased percentage of human papillomavirus (HPV)-related tumors.

STUDY DESIGN

Retrospective cohort analysis was done using the Surveillance, Epidemiology, and End-Results (SEER) database of the national cancer institute.

METHODS

SEER data were used to design seven cohorts: 1975-1979, 1980-1984, 1985-1989, 1990-1994, 1995-1999, 2000-2004, and 2005-2006. Incidence rates, histologic tumor grade. and 5-year survival rates were analyzed over time. Further subgroup analysis was performed according to subsite, age, gender, and stage.

RESULTS

In both OC and OP, well-differentiated (grade I) tumors decreased significantly over time, from 33% to 16% between 1975 and 2006 (P < .001). In contrast, poorly differentiated tumors (grade III) significantly increased from 23% to 34% (P < .001). Over time, 5-year survival rates of less differentiated tumors improved 57%, whereas survival of well-differentiated tumors improved only 15.5%. Tonsil, posterior oropharynx and tongue subsites showed the greatest improvement in survival over time.

CONCLUSIONS

Comprehensive population-based analysis of oral cavity and oropharyngeal carcinoma from 1975 to 2006 demonstrated significant trends toward decreased tumor differentiation and increased survival over time. These findings support the influence of HPV in OC/OP carcinoma and may have implications for treatment, prognosis, and possibly prevention.

Authors+Show Affiliations

Department of Otolaryngology, The New York Eye and Ear Infirmary, New York, New York 10003, USA. vmehta@nyee.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20938956

Citation

Mehta, Vikas, et al. "Population-based Analysis of Oral and Oropharyngeal Carcinoma: Changing Trends of Histopathologic Differentiation, Survival and Patient Demographics." The Laryngoscope, vol. 120, no. 11, 2010, pp. 2203-12.
Mehta V, Yu GP, Schantz SP. Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics. Laryngoscope. 2010;120(11):2203-12.
Mehta, V., Yu, G. P., & Schantz, S. P. (2010). Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics. The Laryngoscope, 120(11), pp. 2203-12. doi:10.1002/lary.21129.
Mehta V, Yu GP, Schantz SP. Population-based Analysis of Oral and Oropharyngeal Carcinoma: Changing Trends of Histopathologic Differentiation, Survival and Patient Demographics. Laryngoscope. 2010;120(11):2203-12. PubMed PMID: 20938956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Population-based analysis of oral and oropharyngeal carcinoma: changing trends of histopathologic differentiation, survival and patient demographics. AU - Mehta,Vikas, AU - Yu,Guo-Pei, AU - Schantz,Stimson P, PY - 2010/10/13/entrez PY - 2010/10/13/pubmed PY - 2011/1/8/medline SP - 2203 EP - 12 JF - The Laryngoscope JO - Laryngoscope VL - 120 IS - 11 N2 - OBJECTIVES/HYPOTHESIS: To examine demographic, histologic, and survival trends of oral cavity and oropharyngeal (OC/OP) squamous cell carcinoma (SCCA) patients over the past 3 decades. To test the hypothesis that decreased histologic differentiation and increased disease-specific survival is related to a decline in smoking rates and an increased percentage of human papillomavirus (HPV)-related tumors. STUDY DESIGN: Retrospective cohort analysis was done using the Surveillance, Epidemiology, and End-Results (SEER) database of the national cancer institute. METHODS: SEER data were used to design seven cohorts: 1975-1979, 1980-1984, 1985-1989, 1990-1994, 1995-1999, 2000-2004, and 2005-2006. Incidence rates, histologic tumor grade. and 5-year survival rates were analyzed over time. Further subgroup analysis was performed according to subsite, age, gender, and stage. RESULTS: In both OC and OP, well-differentiated (grade I) tumors decreased significantly over time, from 33% to 16% between 1975 and 2006 (P < .001). In contrast, poorly differentiated tumors (grade III) significantly increased from 23% to 34% (P < .001). Over time, 5-year survival rates of less differentiated tumors improved 57%, whereas survival of well-differentiated tumors improved only 15.5%. Tonsil, posterior oropharynx and tongue subsites showed the greatest improvement in survival over time. CONCLUSIONS: Comprehensive population-based analysis of oral cavity and oropharyngeal carcinoma from 1975 to 2006 demonstrated significant trends toward decreased tumor differentiation and increased survival over time. These findings support the influence of HPV in OC/OP carcinoma and may have implications for treatment, prognosis, and possibly prevention. SN - 1531-4995 UR - https://www.unboundmedicine.com/medline/citation/20938956/Population_based_analysis_of_oral_and_oropharyngeal_carcinoma:_changing_trends_of_histopathologic_differentiation_survival_and_patient_demographics_ L2 - https://doi.org/10.1002/lary.21129 DB - PRIME DP - Unbound Medicine ER -