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Early detection of psychosis: positive effects on 5-year outcome.
Psychol Med. 2011 Jul; 41(7):1461-9.PM

Abstract

BACKGROUND

During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome.

METHOD

During 1997-2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter.

RESULTS

At the start of treatment, ED-patients had shorter DUP and less symptoms than no-ED-patients. There were no significant differences in treatment (psychotherapy and medication) for the 5 years. Mixed-effects modelling showed better scores for the ED group on the Positive and Negative Syndrome Scale negative, depressive and cognitive factors and for global assessment of functioning for social functioning at 5-year follow-up. The ED group also had more contacts with friends. Regression analysis did not find that these differences could be explained by confounders.

CONCLUSIONS

Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis.

Authors+Show Affiliations

Stavanger University Hospital, Psychiatric Clinic, Stavanger, Norway. tkmaclarsen@mac.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20942996

Citation

Larsen, T K., et al. "Early Detection of Psychosis: Positive Effects On 5-year Outcome." Psychological Medicine, vol. 41, no. 7, 2011, pp. 1461-9.
Larsen TK, Melle I, Auestad B, et al. Early detection of psychosis: positive effects on 5-year outcome. Psychol Med. 2011;41(7):1461-9.
Larsen, T. K., Melle, I., Auestad, B., Haahr, U., Joa, I., Johannessen, J. O., Opjordsmoen, S., Rund, B. R., Rossberg, J. I., Simonsen, E., Vaglum, P., Friis, S., & McGlashan, T. (2011). Early detection of psychosis: positive effects on 5-year outcome. Psychological Medicine, 41(7), 1461-9. https://doi.org/10.1017/S0033291710002023
Larsen TK, et al. Early Detection of Psychosis: Positive Effects On 5-year Outcome. Psychol Med. 2011;41(7):1461-9. PubMed PMID: 20942996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early detection of psychosis: positive effects on 5-year outcome. AU - Larsen,T K, AU - Melle,I, AU - Auestad,B, AU - Haahr,U, AU - Joa,I, AU - Johannessen,J O, AU - Opjordsmoen,S, AU - Rund,B R, AU - Rossberg,J I, AU - Simonsen,E, AU - Vaglum,P, AU - Friis,S, AU - McGlashan,T, Y1 - 2010/10/14/ PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2011/10/7/medline SP - 1461 EP - 9 JF - Psychological medicine JO - Psychol Med VL - 41 IS - 7 N2 - BACKGROUND: During the last decades we have seen a new focus on early treatment of psychosis. Several reviews have shown that duration of untreated psychosis (DUP) is correlated to better outcome. However, it is still unknown whether early treatment will lead to a better long-term outcome. This study reports the effects of reducing DUP on 5-year course and outcome. METHOD: During 1997-2000 a total of 281 consecutive patients aged >17 years with first episode non-affective psychosis were recruited, of which 192 participated in the 5-year follow-up. A comprehensive early detection (ED) programme with public information campaigns and low-threshold psychosis detection teams was established in one healthcare area (ED-area), but not in a comparable area (no-ED area). Both areas ran equivalent treatment programmes during the first 2 years and need-adapted treatment thereafter. RESULTS: At the start of treatment, ED-patients had shorter DUP and less symptoms than no-ED-patients. There were no significant differences in treatment (psychotherapy and medication) for the 5 years. Mixed-effects modelling showed better scores for the ED group on the Positive and Negative Syndrome Scale negative, depressive and cognitive factors and for global assessment of functioning for social functioning at 5-year follow-up. The ED group also had more contacts with friends. Regression analysis did not find that these differences could be explained by confounders. CONCLUSIONS: Early treatment had positive effects on clinical and functional status at 5-year follow-up in first episode psychosis. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/20942996/Early_detection_of_psychosis:_positive_effects_on_5_year_outcome_ L2 - https://www.cambridge.org/core/product/identifier/S0033291710002023/type/journal_article DB - PRIME DP - Unbound Medicine ER -