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Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome.

Abstract

Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders, affecting 5-10% of the female population of reproductive age. "Classic" PCOS is characterized by clinical or biochemical hyperandrogenism and oligo-ovulation. According to the 2003 Rotterdam criteria, two additional phenotypes are recognized: (1) the ovulatory patient with androgen excess and polycystic ovarian morphology and (2) the anovulatory patient with polycystic ovarian morphology without androgen excess. PCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased blood pressure, a pro-atherogenic lipid profile, increased inflammatory markers, insulin resistance and abnormal glucose metabolism. Furthermore, the incidence of overt or gestational diabetes mellitus, as well as of preeclampsia is significantly higher in PCOS patients. Among the various PCOS phenotypes, those with evidence of androgen excess have the highest burden of cardiovascular risk. Studies evaluating the incidence of cardiovascular disease in postmenopausal women with PCOS are extremely sparse. The available data so far indicate that coronary heart disease, as well as cerebrovascular disease is more common in postmenopausal PCOS patients. Persisting high androgen levels through the menopause, obesity and maturity onset diabetes mellitus are proposed as the main mechanisms accounting for the increased risk.

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  • Authors+Show Affiliations

    2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, 27, Themistokleous Street, Dionysos, GR-14578 Athens, Greece. ilambrinoudaki@aretaieio.uoa.gr

    Source

    Maturitas 68:1 2011 Jan pg 13-6

    MeSH

    Cardiovascular Diseases
    Diabetes Mellitus, Type 2
    Diabetes, Gestational
    Female
    Humans
    Hyperandrogenism
    Polycystic Ovary Syndrome
    Postmenopause
    Pregnancy
    Risk Factors

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    20943333

    Citation

    Lambrinoudaki, Irene. "Cardiovascular Risk in Postmenopausal Women With the Polycystic Ovary Syndrome." Maturitas, vol. 68, no. 1, 2011, pp. 13-6.
    Lambrinoudaki I. Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. Maturitas. 2011;68(1):13-6.
    Lambrinoudaki, I. (2011). Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. Maturitas, 68(1), pp. 13-6. doi:10.1016/j.maturitas.2010.09.005.
    Lambrinoudaki I. Cardiovascular Risk in Postmenopausal Women With the Polycystic Ovary Syndrome. Maturitas. 2011;68(1):13-6. PubMed PMID: 20943333.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. A1 - Lambrinoudaki,Irene, Y1 - 2010/10/12/ PY - 2010/07/21/received PY - 2010/09/14/revised PY - 2010/09/14/accepted PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2011/4/22/medline SP - 13 EP - 6 JF - Maturitas JO - Maturitas VL - 68 IS - 1 N2 - Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders, affecting 5-10% of the female population of reproductive age. "Classic" PCOS is characterized by clinical or biochemical hyperandrogenism and oligo-ovulation. According to the 2003 Rotterdam criteria, two additional phenotypes are recognized: (1) the ovulatory patient with androgen excess and polycystic ovarian morphology and (2) the anovulatory patient with polycystic ovarian morphology without androgen excess. PCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased blood pressure, a pro-atherogenic lipid profile, increased inflammatory markers, insulin resistance and abnormal glucose metabolism. Furthermore, the incidence of overt or gestational diabetes mellitus, as well as of preeclampsia is significantly higher in PCOS patients. Among the various PCOS phenotypes, those with evidence of androgen excess have the highest burden of cardiovascular risk. Studies evaluating the incidence of cardiovascular disease in postmenopausal women with PCOS are extremely sparse. The available data so far indicate that coronary heart disease, as well as cerebrovascular disease is more common in postmenopausal PCOS patients. Persisting high androgen levels through the menopause, obesity and maturity onset diabetes mellitus are proposed as the main mechanisms accounting for the increased risk. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/20943333/Cardiovascular_risk_in_postmenopausal_women_with_the_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(10)00349-X DB - PRIME DP - Unbound Medicine ER -