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Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome.
Maturitas 2011; 68(1):13-6M

Abstract

Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders, affecting 5-10% of the female population of reproductive age. "Classic" PCOS is characterized by clinical or biochemical hyperandrogenism and oligo-ovulation. According to the 2003 Rotterdam criteria, two additional phenotypes are recognized: (1) the ovulatory patient with androgen excess and polycystic ovarian morphology and (2) the anovulatory patient with polycystic ovarian morphology without androgen excess. PCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased blood pressure, a pro-atherogenic lipid profile, increased inflammatory markers, insulin resistance and abnormal glucose metabolism. Furthermore, the incidence of overt or gestational diabetes mellitus, as well as of preeclampsia is significantly higher in PCOS patients. Among the various PCOS phenotypes, those with evidence of androgen excess have the highest burden of cardiovascular risk. Studies evaluating the incidence of cardiovascular disease in postmenopausal women with PCOS are extremely sparse. The available data so far indicate that coronary heart disease, as well as cerebrovascular disease is more common in postmenopausal PCOS patients. Persisting high androgen levels through the menopause, obesity and maturity onset diabetes mellitus are proposed as the main mechanisms accounting for the increased risk.

Authors+Show Affiliations

2nd Department of Obstetrics and Gynecology, University of Athens, Aretaieio Hospital, 27, Themistokleous Street, Dionysos, GR-14578 Athens, Greece. ilambrinoudaki@aretaieio.uoa.gr

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20943333

Citation

Lambrinoudaki, Irene. "Cardiovascular Risk in Postmenopausal Women With the Polycystic Ovary Syndrome." Maturitas, vol. 68, no. 1, 2011, pp. 13-6.
Lambrinoudaki I. Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. Maturitas. 2011;68(1):13-6.
Lambrinoudaki, I. (2011). Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. Maturitas, 68(1), pp. 13-6. doi:10.1016/j.maturitas.2010.09.005.
Lambrinoudaki I. Cardiovascular Risk in Postmenopausal Women With the Polycystic Ovary Syndrome. Maturitas. 2011;68(1):13-6. PubMed PMID: 20943333.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular risk in postmenopausal women with the polycystic ovary syndrome. A1 - Lambrinoudaki,Irene, Y1 - 2010/10/12/ PY - 2010/07/21/received PY - 2010/09/14/revised PY - 2010/09/14/accepted PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2011/4/22/medline SP - 13 EP - 6 JF - Maturitas JO - Maturitas VL - 68 IS - 1 N2 - Polycystic ovary syndrome (PCOS) is one of the commonest endocrine disorders, affecting 5-10% of the female population of reproductive age. "Classic" PCOS is characterized by clinical or biochemical hyperandrogenism and oligo-ovulation. According to the 2003 Rotterdam criteria, two additional phenotypes are recognized: (1) the ovulatory patient with androgen excess and polycystic ovarian morphology and (2) the anovulatory patient with polycystic ovarian morphology without androgen excess. PCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased blood pressure, a pro-atherogenic lipid profile, increased inflammatory markers, insulin resistance and abnormal glucose metabolism. Furthermore, the incidence of overt or gestational diabetes mellitus, as well as of preeclampsia is significantly higher in PCOS patients. Among the various PCOS phenotypes, those with evidence of androgen excess have the highest burden of cardiovascular risk. Studies evaluating the incidence of cardiovascular disease in postmenopausal women with PCOS are extremely sparse. The available data so far indicate that coronary heart disease, as well as cerebrovascular disease is more common in postmenopausal PCOS patients. Persisting high androgen levels through the menopause, obesity and maturity onset diabetes mellitus are proposed as the main mechanisms accounting for the increased risk. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/20943333/Cardiovascular_risk_in_postmenopausal_women_with_the_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(10)00349-X DB - PRIME DP - Unbound Medicine ER -