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Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms.
J Nutr. 2010 Dec; 140(12):2302S-2311S.JN

Abstract

The apparently smaller LDL cholesterol (LDL-C)-lowering effect of soy in recent studies has prompted the U.S. FDA to reexamine the heart health claim previously allowed for soy products. We therefore attempted to estimate the intrinsic and extrinsic (displacement) potential of soy in reducing LDL-C to determine whether the heart health claim for soy continues to be justified. The intrinsic effect of soy was derived from a meta-analysis using soy studies (20-133 g/d soy protein) included in the recent AHA Soy Advisory. The extrinsic effect of soy in displacing foods higher in saturated fat and cholesterol was estimated using predictive equations for LDL-C and NHANES III population survey data with the substitution of 13-58 g/d soy protein for animal protein foods. The meta-analysis of the AHA Soy Advisory data gave a mean LDL-C reduction of 0.17 mmol/L (n = 22; P < 0.0001) or 4.3% for soy, which was confirmed in 11 studies reporting balanced macronutrient profiles. The estimated displacement value of soy (13-58 g/d) using NHANES III population survey data was a 3.6-6.0% reduction in LDL-C due to displacement of saturated fats and cholesterol from animal foods. The LDL-C reduction attributable to the combined intrinsic and extrinsic effects of soy protein foods ranged from 7.9 to 10.3%. Thus, soy remains one of a few food components that reduces serum cholesterol (>4%) when added to the diet.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Jenkins DJ
Clinical Nutrition and Risk Factor Modification Center, Department of Medicine, St. Michael's Hospital, Toronto, Ontario, Canada. nutritionproject@smh.ca
Mirrahimi A
No affiliation info available
Srichaikul K
No affiliation info available
Berryman CE
No affiliation info available
Wang L
No affiliation info available
Carleton A
No affiliation info available
Abdulnour S
No affiliation info available
Sievenpiper JL
No affiliation info available
Kendall CW
No affiliation info available
Kris-Etherton PM
No affiliation info available

MeSH

CholesterolFoodHealth SurveysHumansSoybean Proteins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20943954

Citation

Jenkins, David J A., et al. "Soy Protein Reduces Serum Cholesterol By Both Intrinsic and Food Displacement Mechanisms." The Journal of Nutrition, vol. 140, no. 12, 2010, 2302S-2311S.
Jenkins DJ, Mirrahimi A, Srichaikul K, et al. Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms. J Nutr. 2010;140(12):2302S-2311S.
Jenkins, D. J., Mirrahimi, A., Srichaikul, K., Berryman, C. E., Wang, L., Carleton, A., Abdulnour, S., Sievenpiper, J. L., Kendall, C. W., & Kris-Etherton, P. M. (2010). Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms. The Journal of Nutrition, 140(12), 2302S-2311S. https://doi.org/10.3945/jn.110.124958
Jenkins DJ, et al. Soy Protein Reduces Serum Cholesterol By Both Intrinsic and Food Displacement Mechanisms. J Nutr. 2010;140(12):2302S-2311S. PubMed PMID: 20943954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Soy protein reduces serum cholesterol by both intrinsic and food displacement mechanisms. AU - Jenkins,David J A, AU - Mirrahimi,Arash, AU - Srichaikul,Korbua, AU - Berryman,Claire E, AU - Wang,Li, AU - Carleton,Amanda, AU - Abdulnour,Shahad, AU - Sievenpiper,John L, AU - Kendall,Cyril W C, AU - Kris-Etherton,Penny M, Y1 - 2010/10/13/ PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2010/12/31/medline SP - 2302S EP - 2311S JF - The Journal of nutrition JO - J Nutr VL - 140 IS - 12 N2 - The apparently smaller LDL cholesterol (LDL-C)-lowering effect of soy in recent studies has prompted the U.S. FDA to reexamine the heart health claim previously allowed for soy products. We therefore attempted to estimate the intrinsic and extrinsic (displacement) potential of soy in reducing LDL-C to determine whether the heart health claim for soy continues to be justified. The intrinsic effect of soy was derived from a meta-analysis using soy studies (20-133 g/d soy protein) included in the recent AHA Soy Advisory. The extrinsic effect of soy in displacing foods higher in saturated fat and cholesterol was estimated using predictive equations for LDL-C and NHANES III population survey data with the substitution of 13-58 g/d soy protein for animal protein foods. The meta-analysis of the AHA Soy Advisory data gave a mean LDL-C reduction of 0.17 mmol/L (n = 22; P < 0.0001) or 4.3% for soy, which was confirmed in 11 studies reporting balanced macronutrient profiles. The estimated displacement value of soy (13-58 g/d) using NHANES III population survey data was a 3.6-6.0% reduction in LDL-C due to displacement of saturated fats and cholesterol from animal foods. The LDL-C reduction attributable to the combined intrinsic and extrinsic effects of soy protein foods ranged from 7.9 to 10.3%. Thus, soy remains one of a few food components that reduces serum cholesterol (>4%) when added to the diet. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/20943954/full_citation DB - PRIME DP - Unbound Medicine ER -
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