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Artemisia princeps extract promoted glucose uptake in cultured L6 muscle cells via glucose transporter 4 translocation.
Biosci Biotechnol Biochem. 2010; 74(10):2036-42.BB

Abstract

Artemisia princeps is a familiar plant as a food substance and medicinal herb. In this study, we evaluated the effects of an ethanol extract of A. princeps (APE) on glucose uptake in differentiated L6 muscle cells. Treatment with APE elevated deoxyglucose uptake, and translocation of the insulin-responsive glucose transporter (GLUT4) to the plasma membrane in L6 myotubes occurred. The PI3K inhibitor LY294002 attenuated glucose uptake induced by APE. Phosphorylation of the Ser(473) residue of Akt was not observed, but phosphorylation of PI3K, Akt (Thr(308)), and atypical PKC was. In addition, APE stimulated phosphorylation of AMP-activated protein kinase (AMPK) at a level similar to 5'-amino-5-imidazolecarboxamide-riboside (AICAR). These results indicate that APE stimulates glucose uptake by inducing GLUT4 translocation, which is in part mediated by combination of the PI3K-dependent atypical PKC pathway and AMPK pathways.

Authors+Show Affiliations

Food Science Research Center, House Wellness Foods Corporation, Imoji, Itami, Japan. Yamamoto_Norio@house-wf.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20944421

Citation

Yamamoto, Norio, et al. "Artemisia Princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells Via Glucose Transporter 4 Translocation." Bioscience, Biotechnology, and Biochemistry, vol. 74, no. 10, 2010, pp. 2036-42.
Yamamoto N, Ueda M, Kawabata K, et al. Artemisia princeps extract promoted glucose uptake in cultured L6 muscle cells via glucose transporter 4 translocation. Biosci Biotechnol Biochem. 2010;74(10):2036-42.
Yamamoto, N., Ueda, M., Kawabata, K., Sato, T., Kawasaki, K., Hashimoto, T., & Ashida, H. (2010). Artemisia princeps extract promoted glucose uptake in cultured L6 muscle cells via glucose transporter 4 translocation. Bioscience, Biotechnology, and Biochemistry, 74(10), 2036-42.
Yamamoto N, et al. Artemisia Princeps Extract Promoted Glucose Uptake in Cultured L6 Muscle Cells Via Glucose Transporter 4 Translocation. Biosci Biotechnol Biochem. 2010;74(10):2036-42. PubMed PMID: 20944421.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Artemisia princeps extract promoted glucose uptake in cultured L6 muscle cells via glucose transporter 4 translocation. AU - Yamamoto,Norio, AU - Ueda,Manabu, AU - Kawabata,Kyuichi, AU - Sato,Takuya, AU - Kawasaki,Kengo, AU - Hashimoto,Takashi, AU - Ashida,Hitoshi, Y1 - 2010/10/07/ PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2011/2/15/medline SP - 2036 EP - 42 JF - Bioscience, biotechnology, and biochemistry JO - Biosci. Biotechnol. Biochem. VL - 74 IS - 10 N2 - Artemisia princeps is a familiar plant as a food substance and medicinal herb. In this study, we evaluated the effects of an ethanol extract of A. princeps (APE) on glucose uptake in differentiated L6 muscle cells. Treatment with APE elevated deoxyglucose uptake, and translocation of the insulin-responsive glucose transporter (GLUT4) to the plasma membrane in L6 myotubes occurred. The PI3K inhibitor LY294002 attenuated glucose uptake induced by APE. Phosphorylation of the Ser(473) residue of Akt was not observed, but phosphorylation of PI3K, Akt (Thr(308)), and atypical PKC was. In addition, APE stimulated phosphorylation of AMP-activated protein kinase (AMPK) at a level similar to 5'-amino-5-imidazolecarboxamide-riboside (AICAR). These results indicate that APE stimulates glucose uptake by inducing GLUT4 translocation, which is in part mediated by combination of the PI3K-dependent atypical PKC pathway and AMPK pathways. SN - 1347-6947 UR - https://www.unboundmedicine.com/medline/citation/20944421/Artemisia_princeps_extract_promoted_glucose_uptake_in_cultured_L6_muscle_cells_via_glucose_transporter_4_translocation_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bbb/100305?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -