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Dietary intake of vitamin D during adolescence and risk of multiple sclerosis.
J Neurol 2011; 258(3):479-85JN

Abstract

Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44 years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of ≥ 400 IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake = 0.73, 95% CI: 0.50-1.07, P = 0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., Boston, MA 02115, USA. kgorham@hsph.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20945071

Citation

Munger, Kassandra L., et al. "Dietary Intake of Vitamin D During Adolescence and Risk of Multiple Sclerosis." Journal of Neurology, vol. 258, no. 3, 2011, pp. 479-85.
Munger KL, Chitnis T, Frazier AL, et al. Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. J Neurol. 2011;258(3):479-85.
Munger, K. L., Chitnis, T., Frazier, A. L., Giovannucci, E., Spiegelman, D., & Ascherio, A. (2011). Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. Journal of Neurology, 258(3), pp. 479-85. doi:10.1007/s00415-010-5783-1.
Munger KL, et al. Dietary Intake of Vitamin D During Adolescence and Risk of Multiple Sclerosis. J Neurol. 2011;258(3):479-85. PubMed PMID: 20945071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. AU - Munger,Kassandra L, AU - Chitnis,Tanuja, AU - Frazier,A Lindsay, AU - Giovannucci,Edward, AU - Spiegelman,Donna, AU - Ascherio,Alberto, Y1 - 2010/10/14/ PY - 2010/05/10/received PY - 2010/09/29/accepted PY - 2010/09/27/revised PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2012/1/10/medline SP - 479 EP - 85 JF - Journal of neurology JO - J. Neurol. VL - 258 IS - 3 N2 - Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44 years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of ≥ 400 IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake = 0.73, 95% CI: 0.50-1.07, P = 0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies. SN - 1432-1459 UR - https://www.unboundmedicine.com/medline/citation/20945071/Dietary_intake_of_vitamin_D_during_adolescence_and_risk_of_multiple_sclerosis_ L2 - https://dx.doi.org/10.1007/s00415-010-5783-1 DB - PRIME DP - Unbound Medicine ER -