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Dietary intake of vitamin D during adolescence and risk of multiple sclerosis.

Abstract

Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44 years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of ≥ 400 IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake = 0.73, 95% CI: 0.50-1.07, P = 0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies.

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  • Authors+Show Affiliations

    ,

    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg. 2, 3rd Fl., Boston, MA 02115, USA. kgorham@hsph.harvard.edu

    , , , ,

    Source

    Journal of neurology 258:3 2011 Mar pg 479-85

    MeSH

    Adolescent
    Adult
    Calcium, Dietary
    Cohort Studies
    Dairy Products
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Multiple Sclerosis
    Risk Factors
    Surveys and Questionnaires
    Vitamin D

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20945071

    Citation

    Munger, Kassandra L., et al. "Dietary Intake of Vitamin D During Adolescence and Risk of Multiple Sclerosis." Journal of Neurology, vol. 258, no. 3, 2011, pp. 479-85.
    Munger KL, Chitnis T, Frazier AL, et al. Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. J Neurol. 2011;258(3):479-85.
    Munger, K. L., Chitnis, T., Frazier, A. L., Giovannucci, E., Spiegelman, D., & Ascherio, A. (2011). Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. Journal of Neurology, 258(3), pp. 479-85. doi:10.1007/s00415-010-5783-1.
    Munger KL, et al. Dietary Intake of Vitamin D During Adolescence and Risk of Multiple Sclerosis. J Neurol. 2011;258(3):479-85. PubMed PMID: 20945071.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of vitamin D during adolescence and risk of multiple sclerosis. AU - Munger,Kassandra L, AU - Chitnis,Tanuja, AU - Frazier,A Lindsay, AU - Giovannucci,Edward, AU - Spiegelman,Donna, AU - Ascherio,Alberto, Y1 - 2010/10/14/ PY - 2010/05/10/received PY - 2010/09/29/accepted PY - 2010/09/27/revised PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2012/1/10/medline SP - 479 EP - 85 JF - Journal of neurology JO - J. Neurol. VL - 258 IS - 3 N2 - Adolescence may be an important etiological period in the development of multiple sclerosis (MS), and studies suggest that adequate vitamin D nutrition is protective. Here, the authors examined whether dietary intake of vitamin D during adolescence decreases the risk of MS in adulthood. In 1986 in the Nurses' Health Study and in 1998 in the Nurses' Health Study II (NHSII), women completed a food frequency questionnaire regarding their dietary intake during adolescence. From this, daily intake of vitamin D was calculated. Adolescent diet was available for 379 incident MS cases confirmed over the combined 44 years of follow-up in both cohorts, and for 67 prevalent cases in the NHSII who had MS at baseline (1989). Cox proportional hazards models were used to calculate relative risk estimates and 95% confidence intervals. Total vitamin D intake during adolescence was not associated with MS risk. Intake of ≥ 400 IU/day of vitamin D from multivitamins was associated with a non-statistically significant reduced risk (RR compared to no intake = 0.73, 95% CI: 0.50-1.07, P = 0.11), whereas intake of whole milk, an important source of dietary vitamin D, was associated with an increased risk. The possibility of opposite effects of vitamin D and milk intake on MS risk should be considered in future studies. SN - 1432-1459 UR - https://www.unboundmedicine.com/medline/citation/20945071/Dietary_intake_of_vitamin_D_during_adolescence_and_risk_of_multiple_sclerosis_ L2 - https://dx.doi.org/10.1007/s00415-010-5783-1 DB - PRIME DP - Unbound Medicine ER -