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Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease.
Mov Disord. 2010 Dec 15; 25(16):2740-6.MD

Abstract

We performed a cross-sectional study of 82 Chinese patients with Parkinson's disease (PD) enrolled during an 18-month period using a clinical interview to assess the prevalence of nonmotor symptoms (NMS), the association with disease severity and motor status, and the impact on patients' health-related quality of life (Hr-QoL). The patients' NMS, Hr-QoL, disease severity, and motor status were assessed by the Nonmotor Symptoms Scale (NMSS), the 39-item Parkinson's Disease Questionnaire (PDQ-39), the modified Hoehn and Yahr staging scale (H&Y) and the Unified Parkinson's Disease Rating Scale part III (UPDRS III), respectively. We found that 100% of patients with PD presented with NMS. The NMSS significantly correlated with disease duration (Spearman's r(S) = 0.276, P = 0.012), H&Y (r(S) = 0.230, P = 0.038), and UPDRS III (r(S) = 0.350, P = 0.001). Similarly, the PDQ-39 SI significantly associated with the disease duration (r(S) = 0.258, P = 0.019), H&Y (r(S) = 0.340, P = 0.002), and UPDRS III (r(S) = 0.453, P < 0.001). NMS domains that influenced the PDQ-39 SI were sleep/fatigue, mood, gastrointestinal, urinary, and miscellaneous symptoms. This strongly suggested that the five domains played a key role in the manifestation of Hr-QoL. NMSS explains more of the variability in Hr-QoL than UPDRS III, when both are the model (stepwise multiple linear regression analysis R² change, 47.8% vs. 5.87%, respectively). Therefore, these findings demonstrate that NMS are independently and negatively associated with Hr-QoL in PD and that improving NMS should be viewed as an important part in the management of PD.

Authors+Show Affiliations

Department of Nursing, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20945434

Citation

Li, Huijuan, et al. "Nonmotor Symptoms Are Independently Associated With Impaired Health-related Quality of Life in Chinese Patients With Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 25, no. 16, 2010, pp. 2740-6.
Li H, Zhang M, Chen L, et al. Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease. Mov Disord. 2010;25(16):2740-6.
Li, H., Zhang, M., Chen, L., Zhang, J., Pei, Z., Hu, A., & Wang, Q. (2010). Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 25(16), 2740-6. https://doi.org/10.1002/mds.23368
Li H, et al. Nonmotor Symptoms Are Independently Associated With Impaired Health-related Quality of Life in Chinese Patients With Parkinson's Disease. Mov Disord. 2010 Dec 15;25(16):2740-6. PubMed PMID: 20945434.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nonmotor symptoms are independently associated with impaired health-related quality of life in Chinese patients with Parkinson's disease. AU - Li,Huijuan, AU - Zhang,Meifen, AU - Chen,Ling, AU - Zhang,June, AU - Pei,Zhong, AU - Hu,Ailing, AU - Wang,Qing, PY - 2010/10/15/entrez PY - 2010/10/15/pubmed PY - 2011/4/9/medline SP - 2740 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 25 IS - 16 N2 - We performed a cross-sectional study of 82 Chinese patients with Parkinson's disease (PD) enrolled during an 18-month period using a clinical interview to assess the prevalence of nonmotor symptoms (NMS), the association with disease severity and motor status, and the impact on patients' health-related quality of life (Hr-QoL). The patients' NMS, Hr-QoL, disease severity, and motor status were assessed by the Nonmotor Symptoms Scale (NMSS), the 39-item Parkinson's Disease Questionnaire (PDQ-39), the modified Hoehn and Yahr staging scale (H&Y) and the Unified Parkinson's Disease Rating Scale part III (UPDRS III), respectively. We found that 100% of patients with PD presented with NMS. The NMSS significantly correlated with disease duration (Spearman's r(S) = 0.276, P = 0.012), H&Y (r(S) = 0.230, P = 0.038), and UPDRS III (r(S) = 0.350, P = 0.001). Similarly, the PDQ-39 SI significantly associated with the disease duration (r(S) = 0.258, P = 0.019), H&Y (r(S) = 0.340, P = 0.002), and UPDRS III (r(S) = 0.453, P < 0.001). NMS domains that influenced the PDQ-39 SI were sleep/fatigue, mood, gastrointestinal, urinary, and miscellaneous symptoms. This strongly suggested that the five domains played a key role in the manifestation of Hr-QoL. NMSS explains more of the variability in Hr-QoL than UPDRS III, when both are the model (stepwise multiple linear regression analysis R² change, 47.8% vs. 5.87%, respectively). Therefore, these findings demonstrate that NMS are independently and negatively associated with Hr-QoL in PD and that improving NMS should be viewed as an important part in the management of PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/20945434/Nonmotor_symptoms_are_independently_associated_with_impaired_health_related_quality_of_life_in_Chinese_patients_with_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.23368 DB - PRIME DP - Unbound Medicine ER -