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Group differences in anterior hippocampal volume and in the retrieval of spatial and temporal context memory in healthy young versus older adults.
Neuropsychologia. 2010 Dec; 48(14):4020-30.N

Abstract

The ability to retrieve temporal and spatial context information from memory declines with healthy aging. The hippocampus (HC) has been shown to be associated with successful encoding and retrieval of spatio-temporal context, versus item recognition information (Davachi, Mitchell, & Wagner, 2003; Nadel, Samsonovich, Ryan, & Moscovitch, 2000; Ross & Slotnick, 2008). Aging has been linked to volume reduction in the HC (Bouchard, Malykhin, Martin, Hanstock, Emery, Fisher, & Camicioli, 2008; Malykhin, Bouchard, Camicioli, & Coupland, 2008; Raz et al., 2005). As such, age-associated reductions in anterior HC volume may contribute to the context memory deficits observed in older adults. In the current MRI study we investigated whether item recognition, spatial context and temporal context memory performance would be predicted by regional volumes in HC head (HH), body (HB) and tail (HT) volumes, using within group multiple regression analyses in a sample of 19 healthy young (mean age 24.3) and 20 older adults (mean age 67.7). We further examined between age-group differences in the volumes of the same HC sub-regions. Multiple regression analyses revealed that in younger adults both spatial and temporal context retrieval performance was predicted by anterior HC volume. Older age was associated with significant volume reductions in HH and HB, but not HT; and with reduced ability to retrieve spatial and temporal contextual details from episodic memory. However, HC volumes did not predict context retrieval performance in older adults. We conclude that individual differences in anterior, not posterior, HC volumes predict context memory performance in young adults. With age there may be a posterior-to-anterior shift from using HC-related processes, due to HC volume loss, to employing the prefrontal cortex to aid in the performance of cognitively demanding context memory tasks. However, due to concomitant changes in the prefrontal system with age, there are limits to compensation in the aging brain.

Authors+Show Affiliations

Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, QC, Canada. natasha.rajah@douglas.mcgill.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20946907

Citation

Rajah, M Natasha, et al. "Group Differences in Anterior Hippocampal Volume and in the Retrieval of Spatial and Temporal Context Memory in Healthy Young Versus Older Adults." Neuropsychologia, vol. 48, no. 14, 2010, pp. 4020-30.
Rajah MN, Kromas M, Han JE, et al. Group differences in anterior hippocampal volume and in the retrieval of spatial and temporal context memory in healthy young versus older adults. Neuropsychologia. 2010;48(14):4020-30.
Rajah, M. N., Kromas, M., Han, J. E., & Pruessner, J. C. (2010). Group differences in anterior hippocampal volume and in the retrieval of spatial and temporal context memory in healthy young versus older adults. Neuropsychologia, 48(14), 4020-30. https://doi.org/10.1016/j.neuropsychologia.2010.10.010
Rajah MN, et al. Group Differences in Anterior Hippocampal Volume and in the Retrieval of Spatial and Temporal Context Memory in Healthy Young Versus Older Adults. Neuropsychologia. 2010;48(14):4020-30. PubMed PMID: 20946907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Group differences in anterior hippocampal volume and in the retrieval of spatial and temporal context memory in healthy young versus older adults. AU - Rajah,M Natasha, AU - Kromas,Michelle, AU - Han,Jung Eun, AU - Pruessner,Jens C, Y1 - 2010/10/12/ PY - 2010/02/17/received PY - 2010/08/23/revised PY - 2010/10/06/accepted PY - 2010/10/16/entrez PY - 2010/10/16/pubmed PY - 2011/3/17/medline SP - 4020 EP - 30 JF - Neuropsychologia JO - Neuropsychologia VL - 48 IS - 14 N2 - The ability to retrieve temporal and spatial context information from memory declines with healthy aging. The hippocampus (HC) has been shown to be associated with successful encoding and retrieval of spatio-temporal context, versus item recognition information (Davachi, Mitchell, & Wagner, 2003; Nadel, Samsonovich, Ryan, & Moscovitch, 2000; Ross & Slotnick, 2008). Aging has been linked to volume reduction in the HC (Bouchard, Malykhin, Martin, Hanstock, Emery, Fisher, & Camicioli, 2008; Malykhin, Bouchard, Camicioli, & Coupland, 2008; Raz et al., 2005). As such, age-associated reductions in anterior HC volume may contribute to the context memory deficits observed in older adults. In the current MRI study we investigated whether item recognition, spatial context and temporal context memory performance would be predicted by regional volumes in HC head (HH), body (HB) and tail (HT) volumes, using within group multiple regression analyses in a sample of 19 healthy young (mean age 24.3) and 20 older adults (mean age 67.7). We further examined between age-group differences in the volumes of the same HC sub-regions. Multiple regression analyses revealed that in younger adults both spatial and temporal context retrieval performance was predicted by anterior HC volume. Older age was associated with significant volume reductions in HH and HB, but not HT; and with reduced ability to retrieve spatial and temporal contextual details from episodic memory. However, HC volumes did not predict context retrieval performance in older adults. We conclude that individual differences in anterior, not posterior, HC volumes predict context memory performance in young adults. With age there may be a posterior-to-anterior shift from using HC-related processes, due to HC volume loss, to employing the prefrontal cortex to aid in the performance of cognitively demanding context memory tasks. However, due to concomitant changes in the prefrontal system with age, there are limits to compensation in the aging brain. SN - 1873-3514 UR - https://www.unboundmedicine.com/medline/citation/20946907/Group_differences_in_anterior_hippocampal_volume_and_in_the_retrieval_of_spatial_and_temporal_context_memory_in_healthy_young_versus_older_adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0028-3932(10)00436-7 DB - PRIME DP - Unbound Medicine ER -