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Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries.
Neuroepidemiology. 2010; 35(4):281-90.N

Abstract

BACKGROUND

The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, modeled 25-hydroxyvitamin D [25(OH)D] levels and incidence rates of cancer of the brain.

METHODS

Associations of latitude and UVB irradiance with age-standardized incidence rates of cancer of the brain were analyzed for 175 countries while controlling for proportion of population overweight, energy from animal sources, fish consumption, cigarette and alcohol consumption and per capita health expenditures, using multiple regression. Serum 25(OH)D levels were modeled for each country, and their association with brain cancer also was determined.

RESULTS

The incidence rates of brain cancer were higher at higher latitudes (R(2) for males = 0.45, p ≤ 0.0001; R(2) for females = 0.35, p < 0.0001). After adjustment for potential confounders, UVB irradiance (p ≤ 0.0001) and modeled serum 25(OH)D were inversely associated with incidence rates.

CONCLUSIONS

Countries with low solar UVB irradiance and estimated mean serum 25(OH)D levels generally had higher age-standardized incidence rates of brain cancer. Since this was an ecological study, further research would be worthwhile on the association of prediagnostic serum 25(OH)D with incidence rate in studies of cohorts of individuals.

Authors+Show Affiliations

Department of Family and Preventive Medicine, University of California San Diego, La Jolla, CA 92093-0620, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20948235

Citation

Mohr, Sharif B., et al. "Low Ultraviolet B and Increased Risk of Brain Cancer: an Ecological Study of 175 Countries." Neuroepidemiology, vol. 35, no. 4, 2010, pp. 281-90.
Mohr SB, Gorham ED, Garland CF, et al. Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries. Neuroepidemiology. 2010;35(4):281-90.
Mohr, S. B., Gorham, E. D., Garland, C. F., Grant, W. B., & Garland, F. C. (2010). Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries. Neuroepidemiology, 35(4), 281-90. https://doi.org/10.1159/000314350
Mohr SB, et al. Low Ultraviolet B and Increased Risk of Brain Cancer: an Ecological Study of 175 Countries. Neuroepidemiology. 2010;35(4):281-90. PubMed PMID: 20948235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low ultraviolet B and increased risk of brain cancer: an ecological study of 175 countries. AU - Mohr,Sharif B, AU - Gorham,Edward D, AU - Garland,Cedric F, AU - Grant,William B, AU - Garland,Frank C, Y1 - 2010/10/14/ PY - 2009/06/28/received PY - 2010/04/22/accepted PY - 2010/10/16/entrez PY - 2010/10/16/pubmed PY - 2011/3/3/medline SP - 281 EP - 90 JF - Neuroepidemiology JO - Neuroepidemiology VL - 35 IS - 4 N2 - BACKGROUND: The purpose of this study was to determine whether an inverse association exists between latitude, solar ultraviolet B (UVB) irradiance, modeled 25-hydroxyvitamin D [25(OH)D] levels and incidence rates of cancer of the brain. METHODS: Associations of latitude and UVB irradiance with age-standardized incidence rates of cancer of the brain were analyzed for 175 countries while controlling for proportion of population overweight, energy from animal sources, fish consumption, cigarette and alcohol consumption and per capita health expenditures, using multiple regression. Serum 25(OH)D levels were modeled for each country, and their association with brain cancer also was determined. RESULTS: The incidence rates of brain cancer were higher at higher latitudes (R(2) for males = 0.45, p ≤ 0.0001; R(2) for females = 0.35, p < 0.0001). After adjustment for potential confounders, UVB irradiance (p ≤ 0.0001) and modeled serum 25(OH)D were inversely associated with incidence rates. CONCLUSIONS: Countries with low solar UVB irradiance and estimated mean serum 25(OH)D levels generally had higher age-standardized incidence rates of brain cancer. Since this was an ecological study, further research would be worthwhile on the association of prediagnostic serum 25(OH)D with incidence rate in studies of cohorts of individuals. SN - 1423-0208 UR - https://www.unboundmedicine.com/medline/citation/20948235/Low_ultraviolet_B_and_increased_risk_of_brain_cancer:_an_ecological_study_of_175_countries_ L2 - https://www.karger.com?DOI=10.1159/000314350 DB - PRIME DP - Unbound Medicine ER -