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Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies.
J Bone Miner Res 2011; 26(4):833-9JB

Abstract

Milk contains calcium, phosphorus, and protein and is fortified with vitamin D in the United States. All these ingredients may improve bone health. However, the potential benefit of milk on hip fracture prevention is not well established. The objective of this study was to assess the association of milk intake with risk of hip fracture based on a meta-analysis of cohort studies in middle-aged or older men and women. Data sources for this study were English and non-English publications via Medline (Ovid, PubMed) and EMBASE search up to June 2010, experts in the field, and reference lists. The idea was to compare prospective cohort studies on the same scale so that we could calculate the relative risk (RR) of hip fracture per glass of milk intake daily (approximately 300 mg calcium per glass of milk). Pooled analyses were based on random effects models. The data were extracted by two independent observers. The results show that in women (6 studies, 195,102 women, 3574 hip fractures), there was no overall association between total milk intake and hip fracture risk (pooled RR per glass of milk per day = 0.99; 95% confidence interval [CI] 0.96-1.02; Q-test p = .37). In men (3 studies, 75,149 men, 195 hip fractures), the pooled RR per daily glass of milk was 0.91 (95% CI 0.81-1.01). Our conclusion is that in our meta-analysis of cohort studies, there was no overall association between milk intake and hip fracture risk in women but that more data are needed in men.

Authors+Show Affiliations

Centre on Aging and Mobility, University of Zurich, Zurich, Switzerland. Heike.Bischoff@usz.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

20949604

Citation

Bischoff-Ferrari, Heike A., et al. "Milk Intake and Risk of Hip Fracture in Men and Women: a Meta-analysis of Prospective Cohort Studies." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 26, no. 4, 2011, pp. 833-9.
Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, et al. Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. J Bone Miner Res. 2011;26(4):833-9.
Bischoff-Ferrari, H. A., Dawson-Hughes, B., Baron, J. A., Kanis, J. A., Orav, E. J., Staehelin, H. B., ... Willett, W. C. (2011). Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 26(4), pp. 833-9. doi:10.1002/jbmr.279.
Bischoff-Ferrari HA, et al. Milk Intake and Risk of Hip Fracture in Men and Women: a Meta-analysis of Prospective Cohort Studies. J Bone Miner Res. 2011;26(4):833-9. PubMed PMID: 20949604.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Milk intake and risk of hip fracture in men and women: a meta-analysis of prospective cohort studies. AU - Bischoff-Ferrari,Heike A, AU - Dawson-Hughes,Bess, AU - Baron,John A, AU - Kanis,John A, AU - Orav,Endel J, AU - Staehelin,Hannes B, AU - Kiel,Douglas P, AU - Burckhardt,Peter, AU - Henschkowski,Jana, AU - Spiegelman,Donna, AU - Li,Ruifeng, AU - Wong,John B, AU - Feskanich,Diane, AU - Willett,Walter C, PY - 2010/10/16/entrez PY - 2010/10/16/pubmed PY - 2011/9/3/medline SP - 833 EP - 9 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 26 IS - 4 N2 - Milk contains calcium, phosphorus, and protein and is fortified with vitamin D in the United States. All these ingredients may improve bone health. However, the potential benefit of milk on hip fracture prevention is not well established. The objective of this study was to assess the association of milk intake with risk of hip fracture based on a meta-analysis of cohort studies in middle-aged or older men and women. Data sources for this study were English and non-English publications via Medline (Ovid, PubMed) and EMBASE search up to June 2010, experts in the field, and reference lists. The idea was to compare prospective cohort studies on the same scale so that we could calculate the relative risk (RR) of hip fracture per glass of milk intake daily (approximately 300 mg calcium per glass of milk). Pooled analyses were based on random effects models. The data were extracted by two independent observers. The results show that in women (6 studies, 195,102 women, 3574 hip fractures), there was no overall association between total milk intake and hip fracture risk (pooled RR per glass of milk per day = 0.99; 95% confidence interval [CI] 0.96-1.02; Q-test p = .37). In men (3 studies, 75,149 men, 195 hip fractures), the pooled RR per daily glass of milk was 0.91 (95% CI 0.81-1.01). Our conclusion is that in our meta-analysis of cohort studies, there was no overall association between milk intake and hip fracture risk in women but that more data are needed in men. SN - 1523-4681 UR - https://www.unboundmedicine.com/medline/citation/20949604/full_citation L2 - https://doi.org/10.1002/jbmr.279 DB - PRIME DP - Unbound Medicine ER -