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[Epigenetics and memory].
Biol Aujourdhui. 2010; 204(2):131-7.BA

Abstract

The epigenetic marking of chromatin in the brain has recently been recognized as an essential mechanism for brain functions such as learning and memory formation. It allows nerve cells not only to respond to environmental stimuli and modulate their profile of gene expression, but also to establish and maintain their own identity. The epigenetic code is conferred by a set of covalent modifications on the basic elements of chromatin, DNA and histone proteins. These changes are catalyzed by specific enzymes and mechanisms, which include DNA methylation, and post-translational modifications of histone proteins such as acetylation, phosphorylation, methylation and ubiquitination. They are both stable and highly dynamic, and are triggered during stimulation of neuronal circuits but can also persist thereafter. Their study in animal models has demonstrated their importance, and revealed some of their modes of function.

Authors+Show Affiliations

Brain Research Institute, University of Zurich, Zurich, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

20950557

Citation

Gräff, Johannes, et al. "[Epigenetics and Memory]." Biologie Aujourd'hui, vol. 204, no. 2, 2010, pp. 131-7.
Gräff J, Franklin TB, Mansuy IM. [Epigenetics and memory]. Biol Aujourdhui. 2010;204(2):131-7.
Gräff, J., Franklin, T. B., & Mansuy, I. M. (2010). [Epigenetics and memory]. Biologie Aujourd'hui, 204(2), 131-7. https://doi.org/10.1051/jbio/2010007
Gräff J, Franklin TB, Mansuy IM. [Epigenetics and Memory]. Biol Aujourdhui. 2010;204(2):131-7. PubMed PMID: 20950557.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Epigenetics and memory]. AU - Gräff,Johannes, AU - Franklin,Tamara B, AU - Mansuy,Isabelle M, Y1 - 2010/06/21/ PY - 2010/01/03/received PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2010/11/17/medline SP - 131 EP - 7 JF - Biologie aujourd'hui JO - Biol Aujourdhui VL - 204 IS - 2 N2 - The epigenetic marking of chromatin in the brain has recently been recognized as an essential mechanism for brain functions such as learning and memory formation. It allows nerve cells not only to respond to environmental stimuli and modulate their profile of gene expression, but also to establish and maintain their own identity. The epigenetic code is conferred by a set of covalent modifications on the basic elements of chromatin, DNA and histone proteins. These changes are catalyzed by specific enzymes and mechanisms, which include DNA methylation, and post-translational modifications of histone proteins such as acetylation, phosphorylation, methylation and ubiquitination. They are both stable and highly dynamic, and are triggered during stimulation of neuronal circuits but can also persist thereafter. Their study in animal models has demonstrated their importance, and revealed some of their modes of function. SN - 2105-0678 UR - https://www.unboundmedicine.com/medline/citation/20950557/abstract/[Epigenetics_and_memory]_ L2 - https://medlineplus.gov/memory.html DB - PRIME DP - Unbound Medicine ER -