Tags

Type your tag names separated by a space and hit enter

Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats.
Chem Biol Interact. 2011 Jan 15; 189(1-2):100-6.CB

Abstract

Increased oxidative stress and impaired antioxidant defense mechanism are important factors in the pathogenesis and progression of diabetes mellitus and other oxidant-related diseases. The present study was undertaken to evaluate the possible protective effects of S-allyl cysteine (SAC) against oxidative stress in streptozotocin (STZ) induced diabetic rats. SAC was administered orally for 45 days to control and STZ induced diabetic rats. The effects of SAC on glucose, plasma insulin, thiobarbituric acid reactive substances (TBARS), hydroperoxide, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), oxidized glutathione (GSSG) and GSH/GSSG ratio were studied. The levels of glucose, TBARS, hydroperoxide, and GSSG were increased significantly whereas the levels of plasma insulin, reduced glutathione, GSH/GSSG ratio, superoxide dismutase, catalase and GPx were decreased in STZ induced diabetic rats. Administration of SAC to diabetic rats showed a decrease in plasma glucose, TBARS, hydroperoxide and GSSG. In addition, the levels of plasma insulin, superoxide dismutase, catalase, GPx and reduced glutathione (GSH) were increased in SAC treated diabetic rats. The above findings were supported by histological observations of the liver and kidney. The antioxidant effect of SAC was compared with glyclazide, a well-known antioxidant and antihyperglycemic drug. The present study indicates that the SAC possesses a significant favorable effect on antioxidant defense system in addition to its antidiabetic effect.

Links

Publisher Full Text

Authors+Show Affiliations

Saravanan G
Research and Development Centre, Bharathiyar University, Coimbatore, Tamil Nadu, India. saravana_bioc@rediffmail.com
Ponmurugan P
No affiliation info available

MeSH

AnimalsAntioxidantsBlood GlucoseCatalaseCysteineDiabetes Mellitus, ExperimentalGlutathioneGlutathione DisulfideGlutathione PeroxidaseHistocytochemistryInsulinKidneyLiverMaleOxidative StressRatsRats, WistarSuperoxide DismutaseThiobarbituric Acid Reactive Substances

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20951120

Citation

Saravanan, Ganapathy, and Ponnusamy Ponmurugan. "Ameliorative Potential of S-allyl Cysteine On Oxidative Stress in STZ Induced Diabetic Rats." Chemico-biological Interactions, vol. 189, no. 1-2, 2011, pp. 100-6.
Saravanan G, Ponmurugan P. Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chem Biol Interact. 2011;189(1-2):100-6.
Saravanan, G., & Ponmurugan, P. (2011). Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. Chemico-biological Interactions, 189(1-2), 100-6. https://doi.org/10.1016/j.cbi.2010.10.001
Saravanan G, Ponmurugan P. Ameliorative Potential of S-allyl Cysteine On Oxidative Stress in STZ Induced Diabetic Rats. Chem Biol Interact. 2011 Jan 15;189(1-2):100-6. PubMed PMID: 20951120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative potential of S-allyl cysteine on oxidative stress in STZ induced diabetic rats. AU - Saravanan,Ganapathy, AU - Ponmurugan,Ponnusamy, Y1 - 2010/10/14/ PY - 2010/07/24/received PY - 2010/10/05/revised PY - 2010/10/07/accepted PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2011/3/2/medline SP - 100 EP - 6 JF - Chemico-biological interactions JO - Chem Biol Interact VL - 189 IS - 1-2 N2 - Increased oxidative stress and impaired antioxidant defense mechanism are important factors in the pathogenesis and progression of diabetes mellitus and other oxidant-related diseases. The present study was undertaken to evaluate the possible protective effects of S-allyl cysteine (SAC) against oxidative stress in streptozotocin (STZ) induced diabetic rats. SAC was administered orally for 45 days to control and STZ induced diabetic rats. The effects of SAC on glucose, plasma insulin, thiobarbituric acid reactive substances (TBARS), hydroperoxide, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), reduced glutathione (GSH), oxidized glutathione (GSSG) and GSH/GSSG ratio were studied. The levels of glucose, TBARS, hydroperoxide, and GSSG were increased significantly whereas the levels of plasma insulin, reduced glutathione, GSH/GSSG ratio, superoxide dismutase, catalase and GPx were decreased in STZ induced diabetic rats. Administration of SAC to diabetic rats showed a decrease in plasma glucose, TBARS, hydroperoxide and GSSG. In addition, the levels of plasma insulin, superoxide dismutase, catalase, GPx and reduced glutathione (GSH) were increased in SAC treated diabetic rats. The above findings were supported by histological observations of the liver and kidney. The antioxidant effect of SAC was compared with glyclazide, a well-known antioxidant and antihyperglycemic drug. The present study indicates that the SAC possesses a significant favorable effect on antioxidant defense system in addition to its antidiabetic effect. SN - 1872-7786 UR - https://www.unboundmedicine.com/medline/citation/20951120/Ameliorative_potential_of_S_allyl_cysteine_on_oxidative_stress_in_STZ_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-2797(10)00580-6 DB - PRIME DP - Unbound Medicine ER -