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Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin.
Physiol Behav. 2011 Jan 10; 102(1):1-6.PB

Abstract

Nobiletin isolated from citrus peels up-regulates synaptic transmission and improves memory impairment in rodents. This study investigated the antidepressant-like effect of nobiletin in the forced swimming test (FST) and tail suspension test (TST) in mice. Additionally, the monoaminergic mechanisms involved in the antidepressant-like effect of nobiletin in mice were also assessed. Nobiletin (25, 50 and 100mg/kg, p.o.) decreased the immobility time in both the FST and TST without locomotor alterations in the open-field test (OFT). The anti-immobility effect of nobiletin (50mg/kg, p.o.) was completely prevented by the pretreatment of mice with WAY 100635 (0.1mg/kg, s.c., a serotonin 5-HT(1A) receptor antagonist), cyproheptadine (3mg/kg, i.p., a serotonin 5-HT(2) receptor antagonist), prazosin (62.5μg/kg, i.p., an α(1)-adrenoceptor antagonist), SCH23390 (0.05mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50mg/kg, i.p., a dopamine D(2) receptor antagonist). On the other hand, the pretreatment of mice with yohimbine (1mg/kg, i.p., an α(2)-adrenoceptor antagonist) or propranolol (5mg/kg, i.p., a β-adrenoceptor antagonist) did not block the antidepressant-like effect of nobiletin in the TST. Taken together, the data demonstrated that nobiletin produced an antidepressant-like effect that seems to be dependent on its interaction with the serotonergic, noradrenergic and dopaminergic systems. Thus, the present study suggests the therapeutic potential of this dietary flavonoid for the treatment of depression.

Authors+Show Affiliations

Institute of Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China. litaoyi@hqu.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20951716

Citation

Yi, Li-Tao, et al. "Involvement of Monoaminergic Systems in the Antidepressant-like Effect of Nobiletin." Physiology & Behavior, vol. 102, no. 1, 2011, pp. 1-6.
Yi LT, Xu HL, Feng J, et al. Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin. Physiol Behav. 2011;102(1):1-6.
Yi, L. T., Xu, H. L., Feng, J., Zhan, X., Zhou, L. P., & Cui, C. C. (2011). Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin. Physiology & Behavior, 102(1), 1-6. https://doi.org/10.1016/j.physbeh.2010.10.008
Yi LT, et al. Involvement of Monoaminergic Systems in the Antidepressant-like Effect of Nobiletin. Physiol Behav. 2011 Jan 10;102(1):1-6. PubMed PMID: 20951716.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin. AU - Yi,Li-Tao, AU - Xu,He-Li, AU - Feng,Jing, AU - Zhan,Xia, AU - Zhou,Li-Pan, AU - Cui,Cun-Cang, Y1 - 2010/10/15/ PY - 2010/07/20/received PY - 2010/09/23/revised PY - 2010/10/11/accepted PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2011/4/8/medline SP - 1 EP - 6 JF - Physiology & behavior JO - Physiol Behav VL - 102 IS - 1 N2 - Nobiletin isolated from citrus peels up-regulates synaptic transmission and improves memory impairment in rodents. This study investigated the antidepressant-like effect of nobiletin in the forced swimming test (FST) and tail suspension test (TST) in mice. Additionally, the monoaminergic mechanisms involved in the antidepressant-like effect of nobiletin in mice were also assessed. Nobiletin (25, 50 and 100mg/kg, p.o.) decreased the immobility time in both the FST and TST without locomotor alterations in the open-field test (OFT). The anti-immobility effect of nobiletin (50mg/kg, p.o.) was completely prevented by the pretreatment of mice with WAY 100635 (0.1mg/kg, s.c., a serotonin 5-HT(1A) receptor antagonist), cyproheptadine (3mg/kg, i.p., a serotonin 5-HT(2) receptor antagonist), prazosin (62.5μg/kg, i.p., an α(1)-adrenoceptor antagonist), SCH23390 (0.05mg/kg, s.c., a dopamine D(1) receptor antagonist) or sulpiride (50mg/kg, i.p., a dopamine D(2) receptor antagonist). On the other hand, the pretreatment of mice with yohimbine (1mg/kg, i.p., an α(2)-adrenoceptor antagonist) or propranolol (5mg/kg, i.p., a β-adrenoceptor antagonist) did not block the antidepressant-like effect of nobiletin in the TST. Taken together, the data demonstrated that nobiletin produced an antidepressant-like effect that seems to be dependent on its interaction with the serotonergic, noradrenergic and dopaminergic systems. Thus, the present study suggests the therapeutic potential of this dietary flavonoid for the treatment of depression. SN - 1873-507X UR - https://www.unboundmedicine.com/medline/citation/20951716/Involvement_of_monoaminergic_systems_in_the_antidepressant_like_effect_of_nobiletin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9384(10)00361-6 DB - PRIME DP - Unbound Medicine ER -