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MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains.
J Pharmacol Sci. 2010; 114(3):269-75.JP

Abstract

MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains.

Authors+Show Affiliations

Satoh J
Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, Japan. satoj@my-pharm.ac.jp

MeSH

Alzheimer DiseaseBrainGene Expression RegulationHumansMembrane ProteinsMicroRNAsNerve Tissue ProteinsNeurodegenerative DiseasesNeuronsRNA, Messenger

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20953120

Citation

Satoh, Jun-ichi. "MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant microRNA Expression in Alzheimer's Disease Brains." Journal of Pharmacological Sciences, vol. 114, no. 3, 2010, pp. 269-75.
Satoh J. MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains. J Pharmacol Sci. 2010;114(3):269-75.
Satoh, J. (2010). MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains. Journal of Pharmacological Sciences, 114(3), 269-75.
Satoh J. MicroRNAs and Their Therapeutic Potential for Human Diseases: Aberrant microRNA Expression in Alzheimer's Disease Brains. J Pharmacol Sci. 2010;114(3):269-75. PubMed PMID: 20953120.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNAs and their therapeutic potential for human diseases: aberrant microRNA expression in Alzheimer's disease brains. A1 - Satoh,Jun-ichi, Y1 - 2010/10/09/ PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2011/6/7/medline SP - 269 EP - 75 JF - Journal of pharmacological sciences JO - J Pharmacol Sci VL - 114 IS - 3 N2 - MicroRNAs (miRNAs) are a group of small noncoding RNAs that regulate translational repression of multiple target mRNAs. The miRNAs in a whole cell regulate greater than 30% of all protein-coding genes. The vast majority of presently identified miRNAs are expressed in the brain in a spatially and temporally controlled manner. They play a key role in neuronal development, differentiation, and synaptic plasticity. However, at present, the pathological implications of deregulated miRNA expression in neurodegenerative diseases remain largely unknown. This review will briefly summarize recent studies that focus attention on aberrant miRNA expression in Alzheimer's disease brains. SN - 1347-8648 UR - https://www.unboundmedicine.com/medline/citation/20953120/MicroRNAs_and_their_therapeutic_potential_for_human_diseases:_aberrant_microRNA_expression_in_Alzheimer's_disease_brains_ DB - PRIME DP - Unbound Medicine ER -