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The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea.
Acta Diabetol 2013; 50(2):129-34AD

Abstract

Few studies were performed to evaluate the prevalence of latent autoimmune diabetes in adults (LADA) and the difference of chronic complications between LADA, T1DM, and T2DM in Korean. The aim of this study is to establish the prevalence of LADA in a diabetic clinic of Soonchunhyang University hospital and to compare the phenotypic characteristics according to DM classification based on positivity of glutamic acid decarboxylase antibodies (GADA). Also, another important point concerns the occurrence of diabetes chronic microvascular complications in LADA. 323 patients who were checked GADA among diabetic patients admitted at Soonchunhyang University hospital were recruited. Twenty-eight patients (8.7%) were identified as positive for GADA. 11.5% (n = 37) were diagnosed with T1DM and 5.3% (n = 17) were diagnosed with LADA. GADA titer showed significant negative correlation with age of onset, total cholesterol (TC), triglyceride (TG), fasting C-peptide, stimulated C-peptide, BMI, and positive correlation with HbA1C and HDL-C. Compared with those that tested negative for GADA, patients with GADA positive had lower values of onset age, BMI, TC, TG, LDL-C, fasting, and stimulated C-peptide levels and higher values of HbA1C. A significant gradual increase of values was observed for the onset age, BMI, SBP, DBP, fasting, and stimulated C-peptide across the T1DM, LADA, and T2DM subgroups. Concerning the chronic complications there was no difference in prevalence of retinopathy, neuropathy and nephropathy between three groups. Of LADA patients, 12 patients were receiving insulin treatment and mean time to insulin initiation was about 37 months. In conclusion, because our study suggests LADA subgroups in Korea appear to have a faster decline in C-peptide levels, it is worth detecting the patients with LADA early and effort to preserve beta cell function. Furthermore, our results showed that the prevalence of microvascular complication was comparable between the subgroups.

Authors+Show Affiliations

Department of Internal Medicine, Division of Endocrinology and Metabolism, Soonchunhyang University School of Medicine, # 108 Jung-Dong, Wonmi-Ku, Kyunggi-Do, Bucheon, 110-746, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20953640

Citation

Roh, Mi-Oh, et al. "The Prevalence and Characteristics of Latent Autoimmune Diabetes in Adults (LADA) and Its Relation With Chronic Complications in a Clinical Department of a University Hospital in Korea." Acta Diabetologica, vol. 50, no. 2, 2013, pp. 129-34.
Roh MO, Jung CH, Kim BY, et al. The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea. Acta Diabetol. 2013;50(2):129-34.
Roh, M. O., Jung, C. H., Kim, B. Y., Mok, J. O., & Kim, C. H. (2013). The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea. Acta Diabetologica, 50(2), pp. 129-34. doi:10.1007/s00592-010-0228-y.
Roh MO, et al. The Prevalence and Characteristics of Latent Autoimmune Diabetes in Adults (LADA) and Its Relation With Chronic Complications in a Clinical Department of a University Hospital in Korea. Acta Diabetol. 2013;50(2):129-34. PubMed PMID: 20953640.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence and characteristics of latent autoimmune diabetes in adults (LADA) and its relation with chronic complications in a clinical department of a university hospital in Korea. AU - Roh,Mi-Oh, AU - Jung,Chan-Hee, AU - Kim,Bo-Yeon, AU - Mok,Ji-Oh, AU - Kim,Chul-Hee, Y1 - 2010/10/16/ PY - 2010/06/18/received PY - 2010/09/29/accepted PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2013/10/26/medline SP - 129 EP - 34 JF - Acta diabetologica JO - Acta Diabetol VL - 50 IS - 2 N2 - Few studies were performed to evaluate the prevalence of latent autoimmune diabetes in adults (LADA) and the difference of chronic complications between LADA, T1DM, and T2DM in Korean. The aim of this study is to establish the prevalence of LADA in a diabetic clinic of Soonchunhyang University hospital and to compare the phenotypic characteristics according to DM classification based on positivity of glutamic acid decarboxylase antibodies (GADA). Also, another important point concerns the occurrence of diabetes chronic microvascular complications in LADA. 323 patients who were checked GADA among diabetic patients admitted at Soonchunhyang University hospital were recruited. Twenty-eight patients (8.7%) were identified as positive for GADA. 11.5% (n = 37) were diagnosed with T1DM and 5.3% (n = 17) were diagnosed with LADA. GADA titer showed significant negative correlation with age of onset, total cholesterol (TC), triglyceride (TG), fasting C-peptide, stimulated C-peptide, BMI, and positive correlation with HbA1C and HDL-C. Compared with those that tested negative for GADA, patients with GADA positive had lower values of onset age, BMI, TC, TG, LDL-C, fasting, and stimulated C-peptide levels and higher values of HbA1C. A significant gradual increase of values was observed for the onset age, BMI, SBP, DBP, fasting, and stimulated C-peptide across the T1DM, LADA, and T2DM subgroups. Concerning the chronic complications there was no difference in prevalence of retinopathy, neuropathy and nephropathy between three groups. Of LADA patients, 12 patients were receiving insulin treatment and mean time to insulin initiation was about 37 months. In conclusion, because our study suggests LADA subgroups in Korea appear to have a faster decline in C-peptide levels, it is worth detecting the patients with LADA early and effort to preserve beta cell function. Furthermore, our results showed that the prevalence of microvascular complication was comparable between the subgroups. SN - 1432-5233 UR - https://www.unboundmedicine.com/medline/citation/20953640/The_prevalence_and_characteristics_of_latent_autoimmune_diabetes_in_adults__LADA__and_its_relation_with_chronic_complications_in_a_clinical_department_of_a_university_hospital_in_Korea_ L2 - https://dx.doi.org/10.1007/s00592-010-0228-y DB - PRIME DP - Unbound Medicine ER -