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Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study.
Cancer Causes Control 2010; 21(12):2303-8CC

Abstract

OBJECTIVE

Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years.

METHODS

Data came from a national population-based case-control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including self-reported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors.

RESULTS

Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7-9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9-5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk.

CONCLUSIONS

These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.

Authors+Show Affiliations

School of Population Health, The University of Queensland, Herston Road, Herston, QLD 4006, Australia. e.fearnley@uq.edu.au

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20953904

Citation

Fearnley, Emily J., et al. "Polycystic Ovary Syndrome Increases the Risk of Endometrial Cancer in Women Aged Less Than 50 Years: an Australian Case-control Study." Cancer Causes & Control : CCC, vol. 21, no. 12, 2010, pp. 2303-8.
Fearnley EJ, Marquart L, Spurdle AB, et al. Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study. Cancer Causes Control. 2010;21(12):2303-8.
Fearnley, E. J., Marquart, L., Spurdle, A. B., Weinstein, P., & Webb, P. M. (2010). Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study. Cancer Causes & Control : CCC, 21(12), pp. 2303-8. doi:10.1007/s10552-010-9658-7.
Fearnley EJ, et al. Polycystic Ovary Syndrome Increases the Risk of Endometrial Cancer in Women Aged Less Than 50 Years: an Australian Case-control Study. Cancer Causes Control. 2010;21(12):2303-8. PubMed PMID: 20953904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study. AU - Fearnley,Emily J, AU - Marquart,Louise, AU - Spurdle,Amanda B, AU - Weinstein,Philip, AU - Webb,Penelope M, AU - ,, Y1 - 2010/10/17/ PY - 2010/04/18/received PY - 2010/09/29/accepted PY - 2010/10/19/entrez PY - 2010/10/19/pubmed PY - 2011/4/28/medline SP - 2303 EP - 8 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 21 IS - 12 N2 - OBJECTIVE: Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years. METHODS: Data came from a national population-based case-control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including self-reported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors. RESULTS: Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7-9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9-5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk. CONCLUSIONS: These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/20953904/Polycystic_ovary_syndrome_increases_the_risk_of_endometrial_cancer_in_women_aged_less_than_50_years:_an_Australian_case_control_study_ L2 - https://doi.org/10.1007/s10552-010-9658-7 DB - PRIME DP - Unbound Medicine ER -