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Effects of erdosteine on cyclosporine-A-induced hepatotoxicity in rats.
Drug Chem Toxicol 2011; 34(1):32-7DC

Abstract

Cyclosporine A (CsA) is a potent immunosuppressive agent used for organ transplantations and various autoimmune disorders. However, hepatotoxicity due to CsA remains one of the major side effects. The use of antioxidants reduces the adverse effects of CsA. The aim of this study was to determine the protective effects of erdosteine on CsA-induced liver injury through tissue oxidant/antioxidant parameters and to evaluate light microscopic alterations in rat-liver tissues. Rats were randomly divided into four experimental groups: The control group received sunflower oil (2 mL/kg/day, per orally; p.o.), while the other groups were treated with CsA (25 mg/kg/day, p.o.) or erdosteine (10 mg/kg/day, p.o.) or CsA+erdosteine, respectively. Serum aspartate aminotransferase and alanine aminotransferase levels, tissue malondialdehyde and nitric oxide levels, and superoxide dismutase, glutathione peroxidase and catalase enzyme activities were measured. Histological examination was performed. CsA caused a significant deterioration in the hepatic function tests, morphology, and gave rise to severe oxidative stress in the liver. Erdostein significantly improved the functional and histological parameters and attenuated the oxidative stresss induced by CsA. Erdostein protects liver tissue against oxygen free radicals and prevents hepatic dysfunction and morphological abnormalities associated with chronic CsA administration.

Authors+Show Affiliations

Department of Gastroenterology, Fatih University Medical School, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20954827

Citation

Erarslan, Elife, et al. "Effects of Erdosteine On cyclosporine-A-induced Hepatotoxicity in Rats." Drug and Chemical Toxicology, vol. 34, no. 1, 2011, pp. 32-7.
Erarslan E, Ekiz F, Uz B, et al. Effects of erdosteine on cyclosporine-A-induced hepatotoxicity in rats. Drug Chem Toxicol. 2011;34(1):32-7.
Erarslan, E., Ekiz, F., Uz, B., Koca, C., Turkcu, U. O., Bayrak, R., & Delibasi, T. (2011). Effects of erdosteine on cyclosporine-A-induced hepatotoxicity in rats. Drug and Chemical Toxicology, 34(1), pp. 32-7. doi:10.3109/01480545.2010.483519.
Erarslan E, et al. Effects of Erdosteine On cyclosporine-A-induced Hepatotoxicity in Rats. Drug Chem Toxicol. 2011;34(1):32-7. PubMed PMID: 20954827.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of erdosteine on cyclosporine-A-induced hepatotoxicity in rats. AU - Erarslan,Elife, AU - Ekiz,Fuat, AU - Uz,Burak, AU - Koca,Cemile, AU - Turkcu,Ummuhani Ozel, AU - Bayrak,Reyhan, AU - Delibasi,Tuncay, Y1 - 2010/10/18/ PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2011/3/12/medline SP - 32 EP - 7 JF - Drug and chemical toxicology JO - Drug Chem Toxicol VL - 34 IS - 1 N2 - Cyclosporine A (CsA) is a potent immunosuppressive agent used for organ transplantations and various autoimmune disorders. However, hepatotoxicity due to CsA remains one of the major side effects. The use of antioxidants reduces the adverse effects of CsA. The aim of this study was to determine the protective effects of erdosteine on CsA-induced liver injury through tissue oxidant/antioxidant parameters and to evaluate light microscopic alterations in rat-liver tissues. Rats were randomly divided into four experimental groups: The control group received sunflower oil (2 mL/kg/day, per orally; p.o.), while the other groups were treated with CsA (25 mg/kg/day, p.o.) or erdosteine (10 mg/kg/day, p.o.) or CsA+erdosteine, respectively. Serum aspartate aminotransferase and alanine aminotransferase levels, tissue malondialdehyde and nitric oxide levels, and superoxide dismutase, glutathione peroxidase and catalase enzyme activities were measured. Histological examination was performed. CsA caused a significant deterioration in the hepatic function tests, morphology, and gave rise to severe oxidative stress in the liver. Erdostein significantly improved the functional and histological parameters and attenuated the oxidative stresss induced by CsA. Erdostein protects liver tissue against oxygen free radicals and prevents hepatic dysfunction and morphological abnormalities associated with chronic CsA administration. SN - 1525-6014 UR - https://www.unboundmedicine.com/medline/citation/20954827/Effects_of_erdosteine_on_cyclosporine_A_induced_hepatotoxicity_in_rats_ L2 - http://www.tandfonline.com/doi/full/10.3109/01480545.2010.483519 DB - PRIME DP - Unbound Medicine ER -