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Development and evaluation of nifedipine controlled release tablets prepared using mucoadhesive swellable polymer.
Pharm Dev Technol. 2011 Oct; 16(5):536-41.PD

Abstract

Nifedipine is embedded in Gelcarin GP-379 to develop a prolonged release matrix. The effect of polymers levels (15, 20, 30 and 50% w/w), diluent type (lactose Fast Flo, DiTab, and Avicel PH-101), and drug levels (13, 20 and 30% w/w) on in vitro release rate of the drug were investigated. The formulation containing 13% nifedipine, 20% Gelcarin GP-379, and lactose Fast Flo controlled the dissolution rate of nifedipine and released approximately 51% drug at 8 h of testing dissolution. The use of different types of diluents, different drug levels, and different rotational speeds during dissolution testing did affect the drug release rate from the swellable matrices. The dissolution data were analyzed according to Higuchi model, zero order, first order, and Peppas kinetic model. Drug release was found to follow the anomalous diffusion model for swellable matrix.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, School of Pharmacy, University of Puerto Rico, PO Box 365067, San Juan, PR-00936-5067, Puerto Rico.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20954856

Citation

Felician, W A., and E S. Ghaly. "Development and Evaluation of Nifedipine Controlled Release Tablets Prepared Using Mucoadhesive Swellable Polymer." Pharmaceutical Development and Technology, vol. 16, no. 5, 2011, pp. 536-41.
Felician WA, Ghaly ES. Development and evaluation of nifedipine controlled release tablets prepared using mucoadhesive swellable polymer. Pharm Dev Technol. 2011;16(5):536-41.
Felician, W. A., & Ghaly, E. S. (2011). Development and evaluation of nifedipine controlled release tablets prepared using mucoadhesive swellable polymer. Pharmaceutical Development and Technology, 16(5), 536-41. https://doi.org/10.3109/10837450.2010.502176
Felician WA, Ghaly ES. Development and Evaluation of Nifedipine Controlled Release Tablets Prepared Using Mucoadhesive Swellable Polymer. Pharm Dev Technol. 2011;16(5):536-41. PubMed PMID: 20954856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and evaluation of nifedipine controlled release tablets prepared using mucoadhesive swellable polymer. AU - Felician,W A, AU - Ghaly,E S, Y1 - 2010/10/18/ PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2012/2/23/medline SP - 536 EP - 41 JF - Pharmaceutical development and technology JO - Pharm Dev Technol VL - 16 IS - 5 N2 - Nifedipine is embedded in Gelcarin GP-379 to develop a prolonged release matrix. The effect of polymers levels (15, 20, 30 and 50% w/w), diluent type (lactose Fast Flo, DiTab, and Avicel PH-101), and drug levels (13, 20 and 30% w/w) on in vitro release rate of the drug were investigated. The formulation containing 13% nifedipine, 20% Gelcarin GP-379, and lactose Fast Flo controlled the dissolution rate of nifedipine and released approximately 51% drug at 8 h of testing dissolution. The use of different types of diluents, different drug levels, and different rotational speeds during dissolution testing did affect the drug release rate from the swellable matrices. The dissolution data were analyzed according to Higuchi model, zero order, first order, and Peppas kinetic model. Drug release was found to follow the anomalous diffusion model for swellable matrix. SN - 1097-9867 UR - https://www.unboundmedicine.com/medline/citation/20954856/Development_and_evaluation_of_nifedipine_controlled_release_tablets_prepared_using_mucoadhesive_swellable_polymer_ L2 - https://www.tandfonline.com/doi/full/10.3109/10837450.2010.502176 DB - PRIME DP - Unbound Medicine ER -