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Plasma fibroblast growth factor-23 levels are independently associated with carotid artery atherosclerosis in maintenance hemodialysis patients.

Abstract

Fibroblast growth factor-23 (FGF-23) has been suggested to play a role in vascular calcification in chronic kidney disease. Common carotid artery intima-media thickness (CIMT) assessment and common carotid artery (CCA) plaque identification using ultrasound are well-recognized tools for identification and monitoring of atherosclerosis. The aim of this study was to test that elevated FGF-23 levels might be associated with carotid artery atherosclerosis in maintenance hemodialysis (HD) patients. In this cross-sectional study, plasma FGF-23 concentrations were measured using a C-terminal human enzyme-linked immunosorbent assay kit. Carotid artery intima-media thickness was measured and CCA plaques were identified by B-Mode Doppler ultrasound. One hundred twenty-eight maintenance HD patients (65 women and 63 men, mean age: 55.5 ± 13 years, mean HD vintage: 52 ± 10 months, all patients are on HD thrice a week) were involved. The mean CIMT were higher with increasing tertiles of plasma FGF-23 levels (0.66 ± 0.14 vs. 0.75 ± 0.05 vs. 0.86 ± 0.20 mm, P<0.0001). Log plasma FGF-23 were higher in patients with plaques in CCA than patients free of plaques (3.0 ± 0.17 vs. 2.7 ± 0.23, P<0.0001). Significant correlation was recorded between log plasma FGF-23 and CIMT (r=0,497, P=0.0001). In multiple regression analysis, a high log FGF-23 concentration was a significant independent risk factor of an increased CIMT. Further studies are needed to clarify whether an increased plasma FGF-23 level is a marker or a potential mechanism for atherosclerosis in patients with end-stage renal disease.

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  • Authors+Show Affiliations

    ,

    Department of Cardiology, Ministry of Health, Diskapi Training and Research Hospital, Ankara, Turkey.

    , ,

    Source

    MeSH

    Adult
    Aged
    Biomarkers
    Calcinosis
    Carotid Artery Diseases
    Carotid Artery, Common
    Cross-Sectional Studies
    Female
    Fibroblast Growth Factors
    Humans
    Kidney Failure, Chronic
    Male
    Middle Aged
    Renal Dialysis
    Risk Factors
    Tunica Intima
    Tunica Media
    Ultrasonography

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20955275

    Citation

    Balci, Mustafa, et al. "Plasma Fibroblast Growth Factor-23 Levels Are Independently Associated With Carotid Artery Atherosclerosis in Maintenance Hemodialysis Patients." Hemodialysis International. International Symposium On Home Hemodialysis, vol. 14, no. 4, 2010, pp. 425-32.
    Balci M, Kirkpantur A, Gulbay M, et al. Plasma fibroblast growth factor-23 levels are independently associated with carotid artery atherosclerosis in maintenance hemodialysis patients. Hemodial Int. 2010;14(4):425-32.
    Balci, M., Kirkpantur, A., Gulbay, M., & Gurbuz, O. A. (2010). Plasma fibroblast growth factor-23 levels are independently associated with carotid artery atherosclerosis in maintenance hemodialysis patients. Hemodialysis International. International Symposium On Home Hemodialysis, 14(4), pp. 425-32. doi:10.1111/j.1542-4758.2010.00480.x.
    Balci M, et al. Plasma Fibroblast Growth Factor-23 Levels Are Independently Associated With Carotid Artery Atherosclerosis in Maintenance Hemodialysis Patients. Hemodial Int. 2010;14(4):425-32. PubMed PMID: 20955275.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Plasma fibroblast growth factor-23 levels are independently associated with carotid artery atherosclerosis in maintenance hemodialysis patients. AU - Balci,Mustafa, AU - Kirkpantur,Alper, AU - Gulbay,Mutlu, AU - Gurbuz,Oguz Alp, PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2011/2/4/medline SP - 425 EP - 32 JF - Hemodialysis international. International Symposium on Home Hemodialysis JO - Hemodial Int VL - 14 IS - 4 N2 - Fibroblast growth factor-23 (FGF-23) has been suggested to play a role in vascular calcification in chronic kidney disease. Common carotid artery intima-media thickness (CIMT) assessment and common carotid artery (CCA) plaque identification using ultrasound are well-recognized tools for identification and monitoring of atherosclerosis. The aim of this study was to test that elevated FGF-23 levels might be associated with carotid artery atherosclerosis in maintenance hemodialysis (HD) patients. In this cross-sectional study, plasma FGF-23 concentrations were measured using a C-terminal human enzyme-linked immunosorbent assay kit. Carotid artery intima-media thickness was measured and CCA plaques were identified by B-Mode Doppler ultrasound. One hundred twenty-eight maintenance HD patients (65 women and 63 men, mean age: 55.5 ± 13 years, mean HD vintage: 52 ± 10 months, all patients are on HD thrice a week) were involved. The mean CIMT were higher with increasing tertiles of plasma FGF-23 levels (0.66 ± 0.14 vs. 0.75 ± 0.05 vs. 0.86 ± 0.20 mm, P<0.0001). Log plasma FGF-23 were higher in patients with plaques in CCA than patients free of plaques (3.0 ± 0.17 vs. 2.7 ± 0.23, P<0.0001). Significant correlation was recorded between log plasma FGF-23 and CIMT (r=0,497, P=0.0001). In multiple regression analysis, a high log FGF-23 concentration was a significant independent risk factor of an increased CIMT. Further studies are needed to clarify whether an increased plasma FGF-23 level is a marker or a potential mechanism for atherosclerosis in patients with end-stage renal disease. SN - 1542-4758 UR - https://www.unboundmedicine.com/medline/citation/20955275/Plasma_fibroblast_growth_factor_23_levels_are_independently_associated_with_carotid_artery_atherosclerosis_in_maintenance_hemodialysis_patients_ L2 - https://doi.org/10.1111/j.1542-4758.2010.00480.x DB - PRIME DP - Unbound Medicine ER -