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Improvement in cerebral function with treatment of posttraumatic stress disorder.
Ann N Y Acad Sci. 2010 Oct; 1208:142-9.AN

Abstract

Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust.

Authors+Show Affiliations

Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA. mroy@usuhs.milNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20955336

Citation

Roy, Michael J., et al. "Improvement in Cerebral Function With Treatment of Posttraumatic Stress Disorder." Annals of the New York Academy of Sciences, vol. 1208, 2010, pp. 142-9.
Roy MJ, Francis J, Friedlander J, et al. Improvement in cerebral function with treatment of posttraumatic stress disorder. Ann N Y Acad Sci. 2010;1208:142-9.
Roy, M. J., Francis, J., Friedlander, J., Banks-Williams, L., Lande, R. G., Taylor, P., Blair, J., McLellan, J., Law, W., Tarpley, V., Patt, I., Yu, H., Mallinger, A., Difede, J., Rizzo, A., & Rothbaum, B. (2010). Improvement in cerebral function with treatment of posttraumatic stress disorder. Annals of the New York Academy of Sciences, 1208, 142-9. https://doi.org/10.1111/j.1749-6632.2010.05689.x
Roy MJ, et al. Improvement in Cerebral Function With Treatment of Posttraumatic Stress Disorder. Ann N Y Acad Sci. 2010;1208:142-9. PubMed PMID: 20955336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Improvement in cerebral function with treatment of posttraumatic stress disorder. AU - Roy,Michael J, AU - Francis,Jennifer, AU - Friedlander,Joshua, AU - Banks-Williams,Lisa, AU - Lande,Raymond G, AU - Taylor,Patricia, AU - Blair,James, AU - McLellan,Jennifer, AU - Law,Wendy, AU - Tarpley,Vanita, AU - Patt,Ivy, AU - Yu,Henry, AU - Mallinger,Alan, AU - Difede,Joann, AU - Rizzo,Albert, AU - Rothbaum,Barbara, PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2010/11/10/medline SP - 142 EP - 9 JF - Annals of the New York Academy of Sciences JO - Ann N Y Acad Sci VL - 1208 N2 - Posttraumatic stress disorder (PTSD) and mild traumatic brain injury (mTBI) are signature illnesses of the Iraq and Afghanistan wars, but current diagnostic and therapeutic measures for these conditions are suboptimal. In our study, functional magnetic resonance imaging (fMRI) is used to try to differentiate military service members with: PTSD and mTBI, PTSD alone, mTBI alone, and neither PTSD nor mTBI. Those with PTSD are then randomized to virtual reality exposure therapy or imaginal exposure. fMRI is repeated after treatment and along with the Clinician-Administered PTSD Scale (CAPS) and Clinical Global Impression (CGI) scores to compare with baseline. Twenty subjects have completed baseline fMRI scans, including four controls and one mTBI only; of 15 treated for PTSD, eight completed posttreatment scans. Most subjects have been male (93%) and Caucasian (83%), with a mean age of 34. Significant improvements are evident on fMRI scans, and corroborated by CGI scores, but CAPS scores improvements are modest. In conclusion, CGI scores and fMRI scans indicate significant improvement in PTSD in both treatment arms, though CAPS score improvements are less robust. SN - 1749-6632 UR - https://www.unboundmedicine.com/medline/citation/20955336/Improvement_in_cerebral_function_with_treatment_of_posttraumatic_stress_disorder_ L2 - https://doi.org/10.1111/j.1749-6632.2010.05689.x DB - PRIME DP - Unbound Medicine ER -