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Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior?
Wound Repair Regen 2010 Nov-Dec; 18(6):605-13WR

Abstract

Murine models have provided valuable insights into the pathogenesis of both diabetes and chronic wounds. However, only a few published reports to date have investigated wound healing differences among the differing diabetic mouse models. The goal of the present study was to further define the wound healing deficiency phenotypes of streptozotocin-induced (STZ-induced), Akita, and db/db diabetic mice in comparison with a promising new polygenic strain of Type 2 diabetes (NONcNZO10) by using three specific wound models that targeted different critical processes in the pathogenesis of chronic wounds. Incisional, excisional, and ischemia/reperfusion wound models were established on mice of each strain. Wound healing parameters including tensile strength, epithelial gap, and wound necrosis were evaluated. In contrast to the other diabetic mice, the NONcNZO10 strain was found to have significant wound healing impairments in all wound healing models. Not only do the NONcNZO10 mice appear to better model human Type 2 diabetes, these provocative findings suggest that the mice may show more clinically relevant wound healing deficiencies than previous diabetic mouse models.

Authors+Show Affiliations

Laboratory for Wound Repair and Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20955341

Citation

Fang, Robert C., et al. "Limitations of the Db/db Mouse in Translational Wound Healing Research: Is the NONcNZO10 Polygenic Mouse Model Superior?" Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, vol. 18, no. 6, 2010, pp. 605-13.
Fang RC, Kryger ZB, Buck DW, et al. Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior? Wound Repair Regen. 2010;18(6):605-13.
Fang, R. C., Kryger, Z. B., Buck, D. W., De la Garza, M., Galiano, R. D., & Mustoe, T. A. (2010). Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior? Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society, 18(6), pp. 605-13. doi:10.1111/j.1524-475X.2010.00634.x.
Fang RC, et al. Limitations of the Db/db Mouse in Translational Wound Healing Research: Is the NONcNZO10 Polygenic Mouse Model Superior. Wound Repair Regen. 2010;18(6):605-13. PubMed PMID: 20955341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Limitations of the db/db mouse in translational wound healing research: Is the NONcNZO10 polygenic mouse model superior? AU - Fang,Robert C, AU - Kryger,Zol B, AU - Buck,Donald W,2nd AU - De la Garza,Mauricio, AU - Galiano,Robert D, AU - Mustoe,Thomas A, Y1 - 2010/10/18/ PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2011/6/1/medline SP - 605 EP - 13 JF - Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society JO - Wound Repair Regen VL - 18 IS - 6 N2 - Murine models have provided valuable insights into the pathogenesis of both diabetes and chronic wounds. However, only a few published reports to date have investigated wound healing differences among the differing diabetic mouse models. The goal of the present study was to further define the wound healing deficiency phenotypes of streptozotocin-induced (STZ-induced), Akita, and db/db diabetic mice in comparison with a promising new polygenic strain of Type 2 diabetes (NONcNZO10) by using three specific wound models that targeted different critical processes in the pathogenesis of chronic wounds. Incisional, excisional, and ischemia/reperfusion wound models were established on mice of each strain. Wound healing parameters including tensile strength, epithelial gap, and wound necrosis were evaluated. In contrast to the other diabetic mice, the NONcNZO10 strain was found to have significant wound healing impairments in all wound healing models. Not only do the NONcNZO10 mice appear to better model human Type 2 diabetes, these provocative findings suggest that the mice may show more clinically relevant wound healing deficiencies than previous diabetic mouse models. SN - 1524-475X UR - https://www.unboundmedicine.com/medline/citation/20955341/Limitations_of_the_db/db_mouse_in_translational_wound_healing_research:_Is_the_NONcNZO10_polygenic_mouse_model_superior L2 - https://doi.org/10.1111/j.1524-475X.2010.00634.x DB - PRIME DP - Unbound Medicine ER -