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Cronkhite-Canada syndrome associated with rib fractures: a case report.
BMC Gastroenterol. 2010 Oct 18; 10:121.BG

Abstract

BACKGROUND

Cronkhite-Canada syndrome (CCS) is a rare multiple gastrointestinal polyposis. Up till now, many complications of CCS have been reported in the literature, but rib fracture is not included.

CASE PRESENTATION

We report a case of a 58-year-old man who was admitted to our hospital with a 6-month history of frequent diarrhea, intermittent hematochezia and a weight loss of 13 kg. On admission, physical examination revealed alopecia of the scalp, hyperpigmentation of the hands and soles, and dystrophy of the fingernails. Laboratory data revealed hypocalcaemia and hypoproteinemia. Esophagogastroduodenoscopy, video capsule endoscopy and colonoscopy revealed various sizes of generalized gastrointestinal polyps. Histological examination of the biopsy specimens obtained from the stomach and the colon showed adenomatous polyp and inflammatory polyp respectively. Thus, a diagnosis of CCS was made. After treatment with corticosteroids for 24 days and nutritional support for two months, his clinical condition improved. Two months later, he was admitted to our hospital for the second time with frequent diarrhea and weight loss. The chest radiography revealed fractures of the left sixth and seventh ribs. Examinations, including emission computed tomography, bone densitometry test, and other serum parameters, were performed, but could not identify the definite etiology of the rib fractures. One month later, the patient suffered from aggravating multiple rib fractures due to the ineffective treatment, persistent hypocalcaemia and malnutrition.

CONCLUSIONS

This is the first case of a CCS patient with multiple rib fractures. Although the association between CCS and multiple rib fractures in this case remains uncertain, we presume that persistent hypocalcaemia and malnutrition contribute to this situation, or at least aggravate this rare complication. Besides, since prolonged corticosteroid therapy will result in an increased risk of osteoporotic fracture, CCS patients who accept corticosteroid therapy could be potential victims of rib fracture.

Authors+Show Affiliations

Department of Gastroenterology, Jinling Hospital, Jiangsu province, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20955587

Citation

Yuan, Bosi, et al. "Cronkhite-Canada Syndrome Associated With Rib Fractures: a Case Report." BMC Gastroenterology, vol. 10, 2010, p. 121.
Yuan B, Jin X, Zhu R, et al. Cronkhite-Canada syndrome associated with rib fractures: a case report. BMC Gastroenterol. 2010;10:121.
Yuan, B., Jin, X., Zhu, R., Zhang, X., Liu, J., Wan, H., Lu, H., Shen, Y., & Wang, F. (2010). Cronkhite-Canada syndrome associated with rib fractures: a case report. BMC Gastroenterology, 10, 121. https://doi.org/10.1186/1471-230X-10-121
Yuan B, et al. Cronkhite-Canada Syndrome Associated With Rib Fractures: a Case Report. BMC Gastroenterol. 2010 Oct 18;10:121. PubMed PMID: 20955587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cronkhite-Canada syndrome associated with rib fractures: a case report. AU - Yuan,Bosi, AU - Jin,Xinxin, AU - Zhu,Renmin, AU - Zhang,Xiaohua, AU - Liu,Jiong, AU - Wan,Haijun, AU - Lu,Heng, AU - Shen,Yunzhu, AU - Wang,Fangyu, Y1 - 2010/10/18/ PY - 2010/02/20/received PY - 2010/10/18/accepted PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2011/2/2/medline SP - 121 EP - 121 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 10 N2 - BACKGROUND: Cronkhite-Canada syndrome (CCS) is a rare multiple gastrointestinal polyposis. Up till now, many complications of CCS have been reported in the literature, but rib fracture is not included. CASE PRESENTATION: We report a case of a 58-year-old man who was admitted to our hospital with a 6-month history of frequent diarrhea, intermittent hematochezia and a weight loss of 13 kg. On admission, physical examination revealed alopecia of the scalp, hyperpigmentation of the hands and soles, and dystrophy of the fingernails. Laboratory data revealed hypocalcaemia and hypoproteinemia. Esophagogastroduodenoscopy, video capsule endoscopy and colonoscopy revealed various sizes of generalized gastrointestinal polyps. Histological examination of the biopsy specimens obtained from the stomach and the colon showed adenomatous polyp and inflammatory polyp respectively. Thus, a diagnosis of CCS was made. After treatment with corticosteroids for 24 days and nutritional support for two months, his clinical condition improved. Two months later, he was admitted to our hospital for the second time with frequent diarrhea and weight loss. The chest radiography revealed fractures of the left sixth and seventh ribs. Examinations, including emission computed tomography, bone densitometry test, and other serum parameters, were performed, but could not identify the definite etiology of the rib fractures. One month later, the patient suffered from aggravating multiple rib fractures due to the ineffective treatment, persistent hypocalcaemia and malnutrition. CONCLUSIONS: This is the first case of a CCS patient with multiple rib fractures. Although the association between CCS and multiple rib fractures in this case remains uncertain, we presume that persistent hypocalcaemia and malnutrition contribute to this situation, or at least aggravate this rare complication. Besides, since prolonged corticosteroid therapy will result in an increased risk of osteoporotic fracture, CCS patients who accept corticosteroid therapy could be potential victims of rib fracture. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/20955587/Cronkhite_Canada_syndrome_associated_with_rib_fractures:_a_case_report_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-10-121 DB - PRIME DP - Unbound Medicine ER -