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The impact of fruit flavonoids on memory and cognition.
Br J Nutr. 2010 Oct; 104 Suppl 3:S40-7.BJ

Abstract

There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline. Recent evidence has indicated that a group of plant-derived compounds known as flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning. In particular, evidence suggests that foods rich in three specific flavonoid sub-groups, the flavanols, anthocyanins and/or flavanones, possess the greatest potential to act on the cognitive processes. This review will highlight the evidence for the actions of such flavonoids, found most commonly in fruits, such as apples, berries and citrus, on cognitive behaviour and the underlying cellular architecture. Although the precise mechanisms by which these flavonoids act within the brain remain unresolved, the present review focuses on their ability to protect vulnerable neurons and enhance the function of existing neuronal structures, two processes known to be influenced by flavonoids and also known to underpin neuro-cognitive function. Most notably, we discuss their selective interactions with protein kinase and lipid kinase signalling cascades (i.e. phosphoinositide-3 kinase/Akt and mitogen-activated protein kinase pathways), which regulate transcription factors and gene expression involved in both synaptic plasticity and cerebrovascular blood flow. Overall, the review attempts to provide an initial insight into the potential impact of regular flavonoid-rich fruit consumption on normal or abnormal deteriorations in cognitive performance.

Authors+Show Affiliations

Molecular Nutrition Group, School of Chemistry, Food and Pharmacy, University of Reading, Reading, UK. j.p.e.spencer@reading.ac.uk

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20955649

Citation

Spencer, Jeremy P E.. "The Impact of Fruit Flavonoids On Memory and Cognition." The British Journal of Nutrition, vol. 104 Suppl 3, 2010, pp. S40-7.
Spencer JP. The impact of fruit flavonoids on memory and cognition. Br J Nutr. 2010;104 Suppl 3:S40-7.
Spencer, J. P. (2010). The impact of fruit flavonoids on memory and cognition. The British Journal of Nutrition, 104 Suppl 3, S40-7. https://doi.org/10.1017/S0007114510003934
Spencer JP. The Impact of Fruit Flavonoids On Memory and Cognition. Br J Nutr. 2010;104 Suppl 3:S40-7. PubMed PMID: 20955649.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of fruit flavonoids on memory and cognition. A1 - Spencer,Jeremy P E, PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2010/11/3/medline SP - S40 EP - 7 JF - The British journal of nutrition JO - Br J Nutr VL - 104 Suppl 3 N2 - There is intense interest in the studies related to the potential of phytochemical-rich foods to prevent age-related neurodegeneration and cognitive decline. Recent evidence has indicated that a group of plant-derived compounds known as flavonoids may exert particularly powerful actions on mammalian cognition and may reverse age-related declines in memory and learning. In particular, evidence suggests that foods rich in three specific flavonoid sub-groups, the flavanols, anthocyanins and/or flavanones, possess the greatest potential to act on the cognitive processes. This review will highlight the evidence for the actions of such flavonoids, found most commonly in fruits, such as apples, berries and citrus, on cognitive behaviour and the underlying cellular architecture. Although the precise mechanisms by which these flavonoids act within the brain remain unresolved, the present review focuses on their ability to protect vulnerable neurons and enhance the function of existing neuronal structures, two processes known to be influenced by flavonoids and also known to underpin neuro-cognitive function. Most notably, we discuss their selective interactions with protein kinase and lipid kinase signalling cascades (i.e. phosphoinositide-3 kinase/Akt and mitogen-activated protein kinase pathways), which regulate transcription factors and gene expression involved in both synaptic plasticity and cerebrovascular blood flow. Overall, the review attempts to provide an initial insight into the potential impact of regular flavonoid-rich fruit consumption on normal or abnormal deteriorations in cognitive performance. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/20955649/The_impact_of_fruit_flavonoids_on_memory_and_cognition_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510003934/type/journal_article DB - PRIME DP - Unbound Medicine ER -