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Growth hormone-insulin-like growth factor-1 and inflammatory response to a single exercise bout in children and adolescents.

Abstract

Physical activity plays an important role in tissue anabolism, growth and development, but the mechanisms that link patterns of exercise with tissue anabolism are not completely understood. The effectiveness of physical training depends on the training load and on the individual ability to tolerate it, and an imbalance between the two may lead to under or over-training. Therefore, many efforts have been made to find objective parameters to quantify the balance between training load and the athlete's tolerance. One of the unique features of exercise is that it leads to a simultaneous increase of antagonistic mediators. On the one hand, exercise stimulates anabolic components of the growth hormone (GH) → IGF-1 (insulin-like growth factor-1) axis. On the other hand, exercise elevates catabolic pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α). This emphasizes probably the importance of optimal adaptation to exercise in particularly during adolescence. The very fine balance between the anabolic and inflammatory/catabolic response to exercise will determine the effectiveness of exercise training and the health consequences of exercise. If the anabolic response is stronger, exercise will probably lead ultimately to increased muscle mass and improved fitness. A greater catabolic response, in particularly if persists for long duration, may lead to overtraining. Therefore, changes in the anabolic-catabolic hormonal balance and in circulating inflammatory cytokines can be used by adolescent athletes and/or their coaches to gauge the training intensity in individual and team sports.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Child Health and Sports Center, Endocrinology clinic, Pediatric Department, Meir Medical Center, Sackler School of Medicine, Tel-Aviv University, Kfar-Saba, Israel. dnemet@gmail.com

    Source

    Medicine and sport science 55: 2010 pg 141-55

    MeSH

    Adolescent
    Child
    Cytokines
    Exercise
    Growth Hormone
    Humans
    Insulin-Like Growth Factor Binding Proteins
    Insulin-Like Growth Factor I

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    20956866

    Citation

    Nemet, Dan, and Alon Eliakim. "Growth Hormone-insulin-like Growth Factor-1 and Inflammatory Response to a Single Exercise Bout in Children and Adolescents." Medicine and Sport Science, vol. 55, 2010, pp. 141-55.
    Nemet D, Eliakim A. Growth hormone-insulin-like growth factor-1 and inflammatory response to a single exercise bout in children and adolescents. Med Sport Sci. 2010;55:141-55.
    Nemet, D., & Eliakim, A. (2010). Growth hormone-insulin-like growth factor-1 and inflammatory response to a single exercise bout in children and adolescents. Medicine and Sport Science, 55, pp. 141-55. doi:10.1159/000321978.
    Nemet D, Eliakim A. Growth Hormone-insulin-like Growth Factor-1 and Inflammatory Response to a Single Exercise Bout in Children and Adolescents. Med Sport Sci. 2010;55:141-55. PubMed PMID: 20956866.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Growth hormone-insulin-like growth factor-1 and inflammatory response to a single exercise bout in children and adolescents. AU - Nemet,Dan, AU - Eliakim,Alon, Y1 - 2010/10/14/ PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2010/12/25/medline SP - 141 EP - 55 JF - Medicine and sport science JO - Med Sport Sci VL - 55 N2 - Physical activity plays an important role in tissue anabolism, growth and development, but the mechanisms that link patterns of exercise with tissue anabolism are not completely understood. The effectiveness of physical training depends on the training load and on the individual ability to tolerate it, and an imbalance between the two may lead to under or over-training. Therefore, many efforts have been made to find objective parameters to quantify the balance between training load and the athlete's tolerance. One of the unique features of exercise is that it leads to a simultaneous increase of antagonistic mediators. On the one hand, exercise stimulates anabolic components of the growth hormone (GH) → IGF-1 (insulin-like growth factor-1) axis. On the other hand, exercise elevates catabolic pro-inflammatory cytokines such as interleukin-6 (IL-6), IL-1 and tumor necrosis factor-α (TNF-α). This emphasizes probably the importance of optimal adaptation to exercise in particularly during adolescence. The very fine balance between the anabolic and inflammatory/catabolic response to exercise will determine the effectiveness of exercise training and the health consequences of exercise. If the anabolic response is stronger, exercise will probably lead ultimately to increased muscle mass and improved fitness. A greater catabolic response, in particularly if persists for long duration, may lead to overtraining. Therefore, changes in the anabolic-catabolic hormonal balance and in circulating inflammatory cytokines can be used by adolescent athletes and/or their coaches to gauge the training intensity in individual and team sports. SN - 0254-5020 UR - https://www.unboundmedicine.com/medline/citation/20956866/Growth_hormone_insulin_like_growth_factor_1_and_inflammatory_response_to_a_single_exercise_bout_in_children_and_adolescents_ L2 - https://www.karger.com?DOI=10.1159/000321978 DB - PRIME DP - Unbound Medicine ER -