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Fluoroquinolones: then and now.
Compend Contin Educ Vet. 2010 Jul; 32(7):E1-9; quiz E9.CC

Abstract

Fluoroquinolones were discovered in the 1960s as a derivative of the antimalarial drug chloroquine. Over the past 40 years, many fluoroquinolones have been developed for use in human and veterinary medicine. As with all classes of antibiotics, resistance to fluoroquinolones is a serious concern, and multiple avenues for resistance are being investigated. Resistance-associated point mutations in bacterial DNA and, more recently, plasmid-mediated resistance have been reported in both human and veterinary bacterial isolates. This article reviews the history and most current literature on fluoroquinolones approved for use in dogs and cats and the spectra of activity, mechanisms of action, resistance patterns, and recommendations for appropriate clinical use of these drugs.

Authors+Show Affiliations

University of Illinois, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20957609

Citation

Pallo-Zimmerman, Lidia M., et al. "Fluoroquinolones: Then and Now." Compendium (Yardley, PA), vol. 32, no. 7, 2010, pp. E1-9; quiz E9.
Pallo-Zimmerman LM, Byron JK, Graves TK. Fluoroquinolones: then and now. Compend Contin Educ Vet. 2010;32(7):E1-9; quiz E9.
Pallo-Zimmerman, L. M., Byron, J. K., & Graves, T. K. (2010). Fluoroquinolones: then and now. Compendium (Yardley, PA), 32(7), E1-9; quiz E9.
Pallo-Zimmerman LM, Byron JK, Graves TK. Fluoroquinolones: Then and Now. Compend Contin Educ Vet. 2010;32(7):E1-9; quiz E9. PubMed PMID: 20957609.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fluoroquinolones: then and now. AU - Pallo-Zimmerman,Lidia M, AU - Byron,Julie K, AU - Graves,Thomas K, PY - 2010/10/20/entrez PY - 2010/10/20/pubmed PY - 2013/6/26/medline SP - E1-9; quiz E9 JF - Compendium (Yardley, PA) JO - Compend Contin Educ Vet VL - 32 IS - 7 N2 - Fluoroquinolones were discovered in the 1960s as a derivative of the antimalarial drug chloroquine. Over the past 40 years, many fluoroquinolones have been developed for use in human and veterinary medicine. As with all classes of antibiotics, resistance to fluoroquinolones is a serious concern, and multiple avenues for resistance are being investigated. Resistance-associated point mutations in bacterial DNA and, more recently, plasmid-mediated resistance have been reported in both human and veterinary bacterial isolates. This article reviews the history and most current literature on fluoroquinolones approved for use in dogs and cats and the spectra of activity, mechanisms of action, resistance patterns, and recommendations for appropriate clinical use of these drugs. SN - 1940-8315 UR - https://www.unboundmedicine.com/medline/citation/20957609/Fluoroquinolones:_then_and_now_ L2 - https://medlineplus.gov/antibiotics.html DB - PRIME DP - Unbound Medicine ER -