TY - JOUR T1 - Hypertrophic differentiation of chondrocytes in osteoarthritis: the developmental aspect of degenerative joint disorders. A1 - Dreier,Rita, Y1 - 2010/09/16/ PY - 2010/10/21/entrez PY - 2010/10/21/pubmed PY - 2011/4/1/medline SP - 216 EP - 216 JF - Arthritis research & therapy JO - Arthritis Res Ther VL - 12 IS - 5 N2 - Osteoarthritis is characterized by a progressive degradation of articular cartilage leading to loss of joint function. The molecular mechanisms regulating pathogenesis and progression of osteoarthritis are poorly understood. Remarkably, some characteristics of this joint disease resemble chondrocyte differentiation processes during skeletal development by endochondral ossification. In healthy articular cartilage, chondrocytes resist proliferation and terminal differentiation. By contrast, chondrocytes in diseased cartilage progressively proliferate and develop hypertrophy. Moreover, vascularization and focal calcification of joint cartilage are initiated. Signaling molecules that regulate chondrocyte activities in both growth cartilage and permanent articular cartilage during osteoarthritis are thus interesting targets for disease-modifying osteoarthritis therapies. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/20959023/Hypertrophic_differentiation_of_chondrocytes_in_osteoarthritis:_the_developmental_aspect_of_degenerative_joint_disorders_ L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/ar3117 DB - PRIME DP - Unbound Medicine ER -