Prime

Type your tag names separated by a space and hit enter

Metal emissions and urban incident Parkinson disease: a community health study of Medicare beneficiaries by using geographic information systems.

Abstract

Parkinson disease associated with farming and exposure to agricultural chemicals has been reported in numerous studies; little is known about Parkinson disease risk factors for those living in urban areas. The authors investigated the relation between copper, lead, or manganese emissions and Parkinson disease incidence in the urban United States, studying 29 million Medicare beneficiaries in the year 2003. Parkinson disease incidence was determined by using beneficiaries who had not changed residence since 1995. Over 35,000 nonmobile incident Parkinson disease cases, diagnosed by a neurologist, were identified for analysis. Age-, race-, and sex-standardized Parkinson disease incidence was compared between counties with high cumulative industrial release of copper, manganese, or lead (as reported to the Environmental Protection Agency) and counties with no/low reported release of all 3 metals. Parkinson disease incidence (per 100,000) in counties with no/low copper/lead/manganese release was 274.0 (95% confidence interval (CI): 226.8, 353.5). Incidence was greater in counties with high manganese release: 489.4 (95% CI: 368.3, 689.5) (relative risk = 1.78, 95% CI: 1.54, 2.07) and counties with high copper release: 304.2 (95% CI: 276.0, 336.8) (relative risk = 1.1, 95% CI: 0.94, 1.31). Urban Parkinson disease incidence is greater in counties with high reported industrial release of copper or manganese. Environmental exposure to metals may be a risk factor for Parkinson disease in urban areas.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors

    , , , , , ,

    Source

    American journal of epidemiology 172:12 2010 Dec 15 pg 1357-63

    MeSH

    Aged
    Aged, 80 and over
    Environmental Exposure
    Female
    Geographic Information Systems
    Humans
    Incidence
    Male
    Medicare
    Metals, Heavy
    Parkinson Disease
    Retrospective Studies
    Risk Factors
    United States
    Urban Health

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20959505

    Citation

    TY - JOUR T1 - Metal emissions and urban incident Parkinson disease: a community health study of Medicare beneficiaries by using geographic information systems. AU - Willis,Allison W, AU - Evanoff,Bradley A, AU - Lian,Min, AU - Galarza,Aiden, AU - Wegrzyn,Andrew, AU - Schootman,Mario, AU - Racette,Brad A, Y1 - 2010/10/19/ PY - 2010/10/19/aheadofprint PY - 2010/10/21/entrez PY - 2010/10/21/pubmed PY - 2011/1/11/medline SP - 1357 EP - 63 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 172 IS - 12 N2 - Parkinson disease associated with farming and exposure to agricultural chemicals has been reported in numerous studies; little is known about Parkinson disease risk factors for those living in urban areas. The authors investigated the relation between copper, lead, or manganese emissions and Parkinson disease incidence in the urban United States, studying 29 million Medicare beneficiaries in the year 2003. Parkinson disease incidence was determined by using beneficiaries who had not changed residence since 1995. Over 35,000 nonmobile incident Parkinson disease cases, diagnosed by a neurologist, were identified for analysis. Age-, race-, and sex-standardized Parkinson disease incidence was compared between counties with high cumulative industrial release of copper, manganese, or lead (as reported to the Environmental Protection Agency) and counties with no/low reported release of all 3 metals. Parkinson disease incidence (per 100,000) in counties with no/low copper/lead/manganese release was 274.0 (95% confidence interval (CI): 226.8, 353.5). Incidence was greater in counties with high manganese release: 489.4 (95% CI: 368.3, 689.5) (relative risk = 1.78, 95% CI: 1.54, 2.07) and counties with high copper release: 304.2 (95% CI: 276.0, 336.8) (relative risk = 1.1, 95% CI: 0.94, 1.31). Urban Parkinson disease incidence is greater in counties with high reported industrial release of copper or manganese. Environmental exposure to metals may be a risk factor for Parkinson disease in urban areas. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20959505/full_citation L2 - http://aje.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=20959505 ER -