Tags

Type your tag names separated by a space and hit enter

Antimutagenic and antioxidant characteristics of Chukrasia tabularis A Juss extracts.
Int J Toxicol. 2011 Feb; 30(1):21-34.IJ

Abstract

The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro-o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its fractions were more efficient against S9-dependent mutagen in pre-incubation mode of treatment as compared to direct-acting mutagens in both the strains. Methanol extract and its fractions also exhibited strong radical-scavenging potential. High-performance liquid chromatography (HPLC) analysis of methanol extract showed the presence of gallic acid, epicatechin, 7-hydroxycoumarin, and rutin. From the study, it could be concluded that antioxidative and antimutagenic activity of methanol extract and its fractions was related to the synergistic interactions among different chemical compounds.

Links

Publisher Full Text

Authors+Show Affiliations

Kaur R
Department of Botanical and Environmental Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.
Sharma U
No affiliation info available
Singh B
No affiliation info available
Arora S
No affiliation info available

MeSH

AnimalsAntimutagenic AgentsAntioxidantsChromatography, High Pressure LiquidDNADNA DamageDrug AntagonismDrugs, Chinese HerbalFree Radical ScavengersMaleMeliaceaeMicrosomes, LiverMutagensPlant LeavesRatsRibosomal ProteinsSalmonella typhimurium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20959614

Citation

Kaur, Rajbir, et al. "Antimutagenic and Antioxidant Characteristics of Chukrasia Tabularis a Juss Extracts." International Journal of Toxicology, vol. 30, no. 1, 2011, pp. 21-34.
Kaur R, Sharma U, Singh B, et al. Antimutagenic and antioxidant characteristics of Chukrasia tabularis A Juss extracts. Int J Toxicol. 2011;30(1):21-34.
Kaur, R., Sharma, U., Singh, B., & Arora, S. (2011). Antimutagenic and antioxidant characteristics of Chukrasia tabularis A Juss extracts. International Journal of Toxicology, 30(1), 21-34. https://doi.org/10.1177/1091581810385362
Kaur R, et al. Antimutagenic and Antioxidant Characteristics of Chukrasia Tabularis a Juss Extracts. Int J Toxicol. 2011;30(1):21-34. PubMed PMID: 20959614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antimutagenic and antioxidant characteristics of Chukrasia tabularis A Juss extracts. AU - Kaur,Rajbir, AU - Sharma,Upendra, AU - Singh,Bikram, AU - Arora,Saroj, Y1 - 2010/10/19/ PY - 2010/10/21/entrez PY - 2010/10/21/pubmed PY - 2011/6/29/medline SP - 21 EP - 34 JF - International journal of toxicology JO - Int J Toxicol VL - 30 IS - 1 N2 - The current study aims to evaluate the antioxidative and antimutagenic activities of methanol extract and different fractions of Chukrasia tabularis leaves. The antioxidative potential was evaluated using 2,2'-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) cation and superoxide anion radical-scavenging assay. The antimutagenic potential was evaluated against direct-acting mutagens, 4-nitro-o-phenylenediamine and sodium azide; and S9-dependent mutagen, 2-aminofluorene in TA98 and TA100 strains of Salmonella typhimurium using Ames assay. It has been found that methanol extract and its fractions were more efficient against S9-dependent mutagen in pre-incubation mode of treatment as compared to direct-acting mutagens in both the strains. Methanol extract and its fractions also exhibited strong radical-scavenging potential. High-performance liquid chromatography (HPLC) analysis of methanol extract showed the presence of gallic acid, epicatechin, 7-hydroxycoumarin, and rutin. From the study, it could be concluded that antioxidative and antimutagenic activity of methanol extract and its fractions was related to the synergistic interactions among different chemical compounds. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/20959614/Antimutagenic_and_antioxidant_characteristics_of_Chukrasia_tabularis_A_Juss_extracts_ L2 - https://journals.sagepub.com/doi/10.1177/1091581810385362?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -