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Sesquiterpene coumarins from Ferula gumosa.
J Nat Prod. 2010 Nov 29; 73(11):1958-62.JN

Abstract

A new sesquiterpene coumarin, gumosin (1), two new sesquiterpene coumarin glycosides, gumosides A (2) and B (3), and 10 known compounds, namely, cauferoside (4), feselol (5), conferoside, ferilin, ferocaulidin, ligupersin A, conferol, and daucosterol, and the phenolic compounds acantrifoside E and 4-hydroxybenzoic acid 4-(6-O-sulfo)glucopyranoside, were isolated from a methanolic extract of Ferula gumosa roots. The structures of 1-3 were elucidated by spectroscopic data interpretation. The cytotoxic activity of the sesquiterpene coumarin derivatives was evaluated against a small panel of cancer cell lines.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Iranshahi M
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. IranshahiM@mums.ac.ir
Masullo M
No affiliation info available
Asili A
No affiliation info available
Hamedzadeh A
No affiliation info available
Jahanbin B
No affiliation info available
Festa M
No affiliation info available
Capasso A
No affiliation info available
Piacente S
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicCoumarinsDrug Screening Assays, AntitumorFerulaGlycosidesHumansIranMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant RootsSesquiterpenes

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20961138

Citation

Iranshahi, Mehrdad, et al. "Sesquiterpene Coumarins From Ferula Gumosa." Journal of Natural Products, vol. 73, no. 11, 2010, pp. 1958-62.
Iranshahi M, Masullo M, Asili A, et al. Sesquiterpene coumarins from Ferula gumosa. J Nat Prod. 2010;73(11):1958-62.
Iranshahi, M., Masullo, M., Asili, A., Hamedzadeh, A., Jahanbin, B., Festa, M., Capasso, A., & Piacente, S. (2010). Sesquiterpene coumarins from Ferula gumosa. Journal of Natural Products, 73(11), 1958-62. https://doi.org/10.1021/np100487j
Iranshahi M, et al. Sesquiterpene Coumarins From Ferula Gumosa. J Nat Prod. 2010 Nov 29;73(11):1958-62. PubMed PMID: 20961138.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sesquiterpene coumarins from Ferula gumosa. AU - Iranshahi,Mehrdad, AU - Masullo,Milena, AU - Asili,Ali, AU - Hamedzadeh,Ali, AU - Jahanbin,Bentolhoda, AU - Festa,Michela, AU - Capasso,Anna, AU - Piacente,Sonia, Y1 - 2010/10/20/ PY - 2010/10/22/entrez PY - 2010/10/22/pubmed PY - 2010/12/31/medline SP - 1958 EP - 62 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 11 N2 - A new sesquiterpene coumarin, gumosin (1), two new sesquiterpene coumarin glycosides, gumosides A (2) and B (3), and 10 known compounds, namely, cauferoside (4), feselol (5), conferoside, ferilin, ferocaulidin, ligupersin A, conferol, and daucosterol, and the phenolic compounds acantrifoside E and 4-hydroxybenzoic acid 4-(6-O-sulfo)glucopyranoside, were isolated from a methanolic extract of Ferula gumosa roots. The structures of 1-3 were elucidated by spectroscopic data interpretation. The cytotoxic activity of the sesquiterpene coumarin derivatives was evaluated against a small panel of cancer cell lines. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20961138/Sesquiterpene_coumarins_from_Ferula_gumosa_ L2 - https://doi.org/10.1021/np100487j DB - PRIME DP - Unbound Medicine ER -