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Relationship of calcium absorption with 25(OH)D and calcium intake in children with rickets.
Nutr Rev. 2010 Nov; 68(11):682-8.NR

Abstract

Nutritional rickets has long been considered a disease caused by vitamin D deficiency, but recent data indicate that inadequate dietary calcium intake is an important cause of rickets, particularly in tropical countries. Children with rickets due to calcium deficiency do not have very low 25(OH)D concentrations, and serum 1,25(OH)(2) D values are markedly elevated. Studies of Nigerian children with rickets demonstrated they have high fractional calcium absorption. A high-phytate diet was demonstrated to increase calcium absorption compared with the fasting state, and enzymatic dephytinization did not significantly improve calcium absorption. When given vitamin D, children with rickets have a marked increase in 1,25(OH)(2) D concentrations without any change in fractional calcium absorption. No positive relationship was found between fractional calcium absorption and serum 25(OH)D concentrations in children on low-calcium diets. More research is needed to understand the interaction between calcium and vitamin D and the role of vitamin D in calcium absorption.

Authors+Show Affiliations

Department of Family Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. thacher.thomas@mayo.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20961298

Citation

Thacher, Tom D., and Steven A. Abrams. "Relationship of Calcium Absorption With 25(OH)D and Calcium Intake in Children With Rickets." Nutrition Reviews, vol. 68, no. 11, 2010, pp. 682-8.
Thacher TD, Abrams SA. Relationship of calcium absorption with 25(OH)D and calcium intake in children with rickets. Nutr Rev. 2010;68(11):682-8.
Thacher, T. D., & Abrams, S. A. (2010). Relationship of calcium absorption with 25(OH)D and calcium intake in children with rickets. Nutrition Reviews, 68(11), 682-8. https://doi.org/10.1111/j.1753-4887.2010.00338.x
Thacher TD, Abrams SA. Relationship of Calcium Absorption With 25(OH)D and Calcium Intake in Children With Rickets. Nutr Rev. 2010;68(11):682-8. PubMed PMID: 20961298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of calcium absorption with 25(OH)D and calcium intake in children with rickets. AU - Thacher,Tom D, AU - Abrams,Steven A, PY - 2010/10/22/entrez PY - 2010/10/22/pubmed PY - 2010/11/16/medline SP - 682 EP - 8 JF - Nutrition reviews JO - Nutr. Rev. VL - 68 IS - 11 N2 - Nutritional rickets has long been considered a disease caused by vitamin D deficiency, but recent data indicate that inadequate dietary calcium intake is an important cause of rickets, particularly in tropical countries. Children with rickets due to calcium deficiency do not have very low 25(OH)D concentrations, and serum 1,25(OH)(2) D values are markedly elevated. Studies of Nigerian children with rickets demonstrated they have high fractional calcium absorption. A high-phytate diet was demonstrated to increase calcium absorption compared with the fasting state, and enzymatic dephytinization did not significantly improve calcium absorption. When given vitamin D, children with rickets have a marked increase in 1,25(OH)(2) D concentrations without any change in fractional calcium absorption. No positive relationship was found between fractional calcium absorption and serum 25(OH)D concentrations in children on low-calcium diets. More research is needed to understand the interaction between calcium and vitamin D and the role of vitamin D in calcium absorption. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/20961298/Relationship_of_calcium_absorption_with_25_OH_D_and_calcium_intake_in_children_with_rickets_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/j.1753-4887.2010.00338.x DB - PRIME DP - Unbound Medicine ER -