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[The epidemiology of pancreatic cancer].

Abstract

Pancreatic cancer is a relatively uncommon tumor, but even with early diagnosis, mortality rates are high, explaining why this form of cancer has now become a common cause of cancer mortality. There are no screening tests for early detection of pancreatic cancer. It is more common in men than women and is predominantly a disease of elderly people. There is wide variation in the incidence of pancreatic cancer around the world, suggesting that environmental factors are important in the pathogenesis. Smoking is the major known risk factor for pancreatic cancer, while dietary factors seem to be less important. Other possible risk factors include chronic pancreatitis, obesity and type 2 diabetes. Numerous inherited germ line mutations are associated with pancreatic cancer. Of these, hereditary pancreatitis confers the greatest risk, while BRCA2 mutations are the commonest inherited disorder. Polymorphisms in genes that control detoxification of environmental carcinogens and metabolic pathways may alter the risk of pancreatic cancer.

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  • Authors+Show Affiliations

    ,

    Semmelweis Egyetem, Általános Orvostudományi Kar II. Belgyógyászati Klinika Budapest Szentkirályi u. 46. 1088. lakgab@yahoo.com

    Source

    Orvosi hetilap 151:44 2010 Oct 31 pg 1816-22

    MeSH

    Age Factors
    Feeding Behavior
    Female
    Genetic Predisposition to Disease
    Humans
    Incidence
    Male
    Obesity
    Pancreatic Neoplasms
    Pancreatitis
    Risk Factors
    Sex Distribution
    Sex Factors
    Smoking
    United States

    Pub Type(s)

    Journal Article
    Review

    Language

    hun

    PubMed ID

    20961843

    Citation

    Lakatos, Gábor, and Zsolt Tulassay. "[The Epidemiology of Pancreatic Cancer]." Orvosi Hetilap, vol. 151, no. 44, 2010, pp. 1816-22.
    Lakatos G, Tulassay Z. [The epidemiology of pancreatic cancer]. Orv Hetil. 2010;151(44):1816-22.
    Lakatos, G., & Tulassay, Z. (2010). [The epidemiology of pancreatic cancer]. Orvosi Hetilap, 151(44), pp. 1816-22. doi:10.1556/OH.2010.28986.
    Lakatos G, Tulassay Z. [The Epidemiology of Pancreatic Cancer]. Orv Hetil. 2010 Oct 31;151(44):1816-22. PubMed PMID: 20961843.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [The epidemiology of pancreatic cancer]. AU - Lakatos,Gábor, AU - Tulassay,Zsolt, PY - 2010/10/22/entrez PY - 2010/10/22/pubmed PY - 2010/12/14/medline SP - 1816 EP - 22 JF - Orvosi hetilap JO - Orv Hetil VL - 151 IS - 44 N2 - Pancreatic cancer is a relatively uncommon tumor, but even with early diagnosis, mortality rates are high, explaining why this form of cancer has now become a common cause of cancer mortality. There are no screening tests for early detection of pancreatic cancer. It is more common in men than women and is predominantly a disease of elderly people. There is wide variation in the incidence of pancreatic cancer around the world, suggesting that environmental factors are important in the pathogenesis. Smoking is the major known risk factor for pancreatic cancer, while dietary factors seem to be less important. Other possible risk factors include chronic pancreatitis, obesity and type 2 diabetes. Numerous inherited germ line mutations are associated with pancreatic cancer. Of these, hereditary pancreatitis confers the greatest risk, while BRCA2 mutations are the commonest inherited disorder. Polymorphisms in genes that control detoxification of environmental carcinogens and metabolic pathways may alter the risk of pancreatic cancer. SN - 0030-6002 UR - https://www.unboundmedicine.com/medline/citation/20961843/[The_epidemiology_of_pancreatic_cancer]_ L2 - http://www.akademiai.com/doi/full/10.1556/OH.2010.28986?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -