Tags

Type your tag names separated by a space and hit enter

Intakes of dietary iron and heme-iron and risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study.

Abstract

BACKGROUND

Intakes of dietary iron and, in particular, heme iron may increase breast cancer risk because of the prooxidant properties of iron. However, few studies have examined the association of iron and heme-iron intakes with breast cancer risk.

OBJECTIVE

We assessed the association of intakes of dietary iron and heme iron with risk of postmenopausal breast cancer.

DESIGN

We used data from the National Institutes of Health-AARP Diet and Health Study to assess intakes of total dietary iron, iron from meat, iron from red meat, and heme iron in relation to breast cancer risk in 116,674 postmenopausal women who completed a detailed questionnaire regarding meat preparation methods and degrees of doneness. During 6.5 y of follow-up, 3396 cases of invasive breast cancer were identified. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% CIs.

RESULTS

After adjustment for covariates, HRs for the highest compared with the lowest quintiles of intakes of total iron, iron from meat, iron from red meat, and heme iron were all close to unity, and there were no increasing trends with increasing intakes. The multivariable-adjusted HR for the highest compared with the lowest quintile of heme-iron intake was 1.01 (95% CI: 0.89, 1.14; P for trend = 0.97). In addition, no associations were seen when iron variables were stratified by possible effect modifiers or hormone receptor status.

CONCLUSION

The results of this large cohort study do not support an association between iron or heme-iron intakes and postmenopausal breast cancer.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA. geoffrey.kabat@einstein.yu.edu

    , , , , ,

    Source

    MeSH

    Aged
    Breast Neoplasms
    Cohort Studies
    Female
    Heme
    Humans
    Iron, Dietary
    Meat
    Middle Aged
    National Institutes of Health (U.S.)
    Postmenopause
    Proportional Hazards Models
    Risk Factors
    Surveys and Questionnaires
    United States

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20962158

    Citation

    Kabat, Geoffrey C., et al. "Intakes of Dietary Iron and Heme-iron and Risk of Postmenopausal Breast Cancer in the National Institutes of Health-AARP Diet and Health Study." The American Journal of Clinical Nutrition, vol. 92, no. 6, 2010, pp. 1478-83.
    Kabat GC, Cross AJ, Park Y, et al. Intakes of dietary iron and heme-iron and risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr. 2010;92(6):1478-83.
    Kabat, G. C., Cross, A. J., Park, Y., Schatzkin, A., Hollenbeck, A. R., Rohan, T. E., & Sinha, R. (2010). Intakes of dietary iron and heme-iron and risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study. The American Journal of Clinical Nutrition, 92(6), pp. 1478-83. doi:10.3945/ajcn.2010.29753.
    Kabat GC, et al. Intakes of Dietary Iron and Heme-iron and Risk of Postmenopausal Breast Cancer in the National Institutes of Health-AARP Diet and Health Study. Am J Clin Nutr. 2010;92(6):1478-83. PubMed PMID: 20962158.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intakes of dietary iron and heme-iron and risk of postmenopausal breast cancer in the National Institutes of Health-AARP Diet and Health Study. AU - Kabat,Geoffrey C, AU - Cross,Amanda J, AU - Park,Yikyung, AU - Schatzkin,Arthur, AU - Hollenbeck,Albert R, AU - Rohan,Thomas E, AU - Sinha,Rashmi, Y1 - 2010/10/20/ PY - 2010/10/22/entrez PY - 2010/10/22/pubmed PY - 2010/12/25/medline SP - 1478 EP - 83 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 6 N2 - BACKGROUND: Intakes of dietary iron and, in particular, heme iron may increase breast cancer risk because of the prooxidant properties of iron. However, few studies have examined the association of iron and heme-iron intakes with breast cancer risk. OBJECTIVE: We assessed the association of intakes of dietary iron and heme iron with risk of postmenopausal breast cancer. DESIGN: We used data from the National Institutes of Health-AARP Diet and Health Study to assess intakes of total dietary iron, iron from meat, iron from red meat, and heme iron in relation to breast cancer risk in 116,674 postmenopausal women who completed a detailed questionnaire regarding meat preparation methods and degrees of doneness. During 6.5 y of follow-up, 3396 cases of invasive breast cancer were identified. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% CIs. RESULTS: After adjustment for covariates, HRs for the highest compared with the lowest quintiles of intakes of total iron, iron from meat, iron from red meat, and heme iron were all close to unity, and there were no increasing trends with increasing intakes. The multivariable-adjusted HR for the highest compared with the lowest quintile of heme-iron intake was 1.01 (95% CI: 0.89, 1.14; P for trend = 0.97). In addition, no associations were seen when iron variables were stratified by possible effect modifiers or hormone receptor status. CONCLUSION: The results of this large cohort study do not support an association between iron or heme-iron intakes and postmenopausal breast cancer. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20962158/Intakes_of_dietary_iron_and_heme_iron_and_risk_of_postmenopausal_breast_cancer_in_the_National_Institutes_of_Health_AARP_Diet_and_Health_Study_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.29753 DB - PRIME DP - Unbound Medicine ER -