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A-type proanthocyanidins from lychee seeds and their antioxidant and antiviral activities.
J Agric Food Chem. 2010 Nov 24; 58(22):11667-72.JA

Abstract

Two new A-type trimeric proanthocyanidins with two doubly bonded interflavanoid linkages, litchitannin A1 [epicatechin-(2β→O→7,4β→6)-epicatechin-(2β→O→7,4β→8)-catechin] (1) and litchitannin A2 [epicatechin-(2β→O→7,4β→6)-epicatechin-(2β→O→7,4β→6)-epicatechin] (2), were isolated from lychee (Litchi chinensis Sonn. cv. Heiye) seeds together with aesculitannin A (3), epicatechin-(2β→O→7,4β→8)-epiafzelechin-(4α→8)-epicatechin (4), proanthocyanidin A1 (5), proanthocyanidin A2 (6), proanthocyanidin A6 (7), epicatechin-(7,8-bc)-4β-(4-hydroxyphenyl)-dihydro-2(3H)-pyranone (8), and epicatechin (9). Their structures were elucidated on the basis of spectroscopic and chemical evidence. It is the first time that compounds 1-4, 7, and 8 have been reported in this species. Compounds 1-9 showed more potent antioxidant activity than L-ascorbic acid with ferric reducing antioxidant power (FRAP) values of 3.71-24.18 mmol/g and IC50 values of 5.25-20.07 μM toward DPPH radicals. Moreover, litchitannin A2 (2) was found to exhibit in vitro antiviral activity against coxsackie virus B3 (CVB3) and compounds 3 and 6 displayed antiherpes simplex virus 1 (HSV-1) activity.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Xu X
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China.
Xie H
No affiliation info available
Wang Y
No affiliation info available
Wei X
No affiliation info available

MeSH

AntioxidantsAntiviral AgentsHeLa CellsHumansLitchiMolecular StructurePlant ExtractsProanthocyanidinsSeedsViruses

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20964424

Citation

Xu, Xinya, et al. "A-type Proanthocyanidins From Lychee Seeds and Their Antioxidant and Antiviral Activities." Journal of Agricultural and Food Chemistry, vol. 58, no. 22, 2010, pp. 11667-72.
Xu X, Xie H, Wang Y, et al. A-type proanthocyanidins from lychee seeds and their antioxidant and antiviral activities. J Agric Food Chem. 2010;58(22):11667-72.
Xu, X., Xie, H., Wang, Y., & Wei, X. (2010). A-type proanthocyanidins from lychee seeds and their antioxidant and antiviral activities. Journal of Agricultural and Food Chemistry, 58(22), 11667-72. https://doi.org/10.1021/jf1033202
Xu X, et al. A-type Proanthocyanidins From Lychee Seeds and Their Antioxidant and Antiviral Activities. J Agric Food Chem. 2010 Nov 24;58(22):11667-72. PubMed PMID: 20964424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A-type proanthocyanidins from lychee seeds and their antioxidant and antiviral activities. AU - Xu,Xinya, AU - Xie,Haihui, AU - Wang,Yifei, AU - Wei,Xiaoyi, Y1 - 2010/10/22/ PY - 2010/10/23/entrez PY - 2010/10/23/pubmed PY - 2011/3/2/medline SP - 11667 EP - 72 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 58 IS - 22 N2 - Two new A-type trimeric proanthocyanidins with two doubly bonded interflavanoid linkages, litchitannin A1 [epicatechin-(2β→O→7,4β→6)-epicatechin-(2β→O→7,4β→8)-catechin] (1) and litchitannin A2 [epicatechin-(2β→O→7,4β→6)-epicatechin-(2β→O→7,4β→6)-epicatechin] (2), were isolated from lychee (Litchi chinensis Sonn. cv. Heiye) seeds together with aesculitannin A (3), epicatechin-(2β→O→7,4β→8)-epiafzelechin-(4α→8)-epicatechin (4), proanthocyanidin A1 (5), proanthocyanidin A2 (6), proanthocyanidin A6 (7), epicatechin-(7,8-bc)-4β-(4-hydroxyphenyl)-dihydro-2(3H)-pyranone (8), and epicatechin (9). Their structures were elucidated on the basis of spectroscopic and chemical evidence. It is the first time that compounds 1-4, 7, and 8 have been reported in this species. Compounds 1-9 showed more potent antioxidant activity than L-ascorbic acid with ferric reducing antioxidant power (FRAP) values of 3.71-24.18 mmol/g and IC50 values of 5.25-20.07 μM toward DPPH radicals. Moreover, litchitannin A2 (2) was found to exhibit in vitro antiviral activity against coxsackie virus B3 (CVB3) and compounds 3 and 6 displayed antiherpes simplex virus 1 (HSV-1) activity. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/20964424/A_type_proanthocyanidins_from_lychee_seeds_and_their_antioxidant_and_antiviral_activities_ L2 - https://doi.org/10.1021/jf1033202 DB - PRIME DP - Unbound Medicine ER -