Tags

Type your tag names separated by a space and hit enter

You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice.
Gut 2010; 59(12):1625-34Gut

Abstract

OBJECTIVES

Diet plays a crucial role in the development of obesity and insulin resistance via multiple mechanisms. Saturated fatty acids can directly trigger tissue specific proinflammatory pathways via Toll-like receptor-4 (TLR4)-dependent mechanisms. Moreover, diet can change the gut microbiome and increase gut permeability. However, very few studies have addressed the obesity-independent role of diet. Dissecting the effects of diet from those of obesity per se will enhance our understanding of the underlying pathogenesis, and, at the translational level, advance our treatment approaches for obesity and its co-morbidities.

METHODS

Melanin-concentrating hormone (MCH) is an important regulator of appetite and energy balance. MCH-deficient mice are resistant to diet-induced obesity, primarily due to increased locomotor activity. We took advantage of the unique phenotype of these mice to examine the metabolic and inflammatory consequences of a 15-week consumption of a diet high in saturated fat.

RESULTS

MCH-deficient mice chronically exposed to a high-fat diet gain less weight compared to their wild-type littermates, despite similar food intake, and are protected from hepatosteatosis. They also lack obesity-associated upregulation of serum leptin and insulin levels and have improved total body insulin sensitivity. Nevertheless, we found indistinguishable liver-specific innate immune responses in both genotypes associated with high-fat feeding, which involved activation of TLR4 and its downstream effectors, MyD88, p38 MAP kinase and STAT-3.

CONCLUSIONS

Our findings indicate that high-fat feeding is deleterious to the liver, independently of the obesity status. They also suggest that MCH is not necessary for the TLR4-dependent immune response triggered by the high-fat diet.

Authors+Show Affiliations

Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20966023

Citation

Wang, Yan, et al. "You Deserve what You Eat: Lessons Learned From the Study of the Melanin-concentrating Hormone (MCH)-deficient Mice." Gut, vol. 59, no. 12, 2010, pp. 1625-34.
Wang Y, Ziogas DC, Biddinger S, et al. You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice. Gut. 2010;59(12):1625-34.
Wang, Y., Ziogas, D. C., Biddinger, S., & Kokkotou, E. (2010). You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice. Gut, 59(12), pp. 1625-34. doi:10.1136/gut.2010.210526.
Wang Y, et al. You Deserve what You Eat: Lessons Learned From the Study of the Melanin-concentrating Hormone (MCH)-deficient Mice. Gut. 2010;59(12):1625-34. PubMed PMID: 20966023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - You deserve what you eat: lessons learned from the study of the melanin-concentrating hormone (MCH)-deficient mice. AU - Wang,Yan, AU - Ziogas,Dimitrios C, AU - Biddinger,Sudha, AU - Kokkotou,Efi, Y1 - 2010/10/21/ PY - 2010/10/23/entrez PY - 2010/10/23/pubmed PY - 2010/12/14/medline SP - 1625 EP - 34 JF - Gut JO - Gut VL - 59 IS - 12 N2 - OBJECTIVES: Diet plays a crucial role in the development of obesity and insulin resistance via multiple mechanisms. Saturated fatty acids can directly trigger tissue specific proinflammatory pathways via Toll-like receptor-4 (TLR4)-dependent mechanisms. Moreover, diet can change the gut microbiome and increase gut permeability. However, very few studies have addressed the obesity-independent role of diet. Dissecting the effects of diet from those of obesity per se will enhance our understanding of the underlying pathogenesis, and, at the translational level, advance our treatment approaches for obesity and its co-morbidities. METHODS: Melanin-concentrating hormone (MCH) is an important regulator of appetite and energy balance. MCH-deficient mice are resistant to diet-induced obesity, primarily due to increased locomotor activity. We took advantage of the unique phenotype of these mice to examine the metabolic and inflammatory consequences of a 15-week consumption of a diet high in saturated fat. RESULTS: MCH-deficient mice chronically exposed to a high-fat diet gain less weight compared to their wild-type littermates, despite similar food intake, and are protected from hepatosteatosis. They also lack obesity-associated upregulation of serum leptin and insulin levels and have improved total body insulin sensitivity. Nevertheless, we found indistinguishable liver-specific innate immune responses in both genotypes associated with high-fat feeding, which involved activation of TLR4 and its downstream effectors, MyD88, p38 MAP kinase and STAT-3. CONCLUSIONS: Our findings indicate that high-fat feeding is deleterious to the liver, independently of the obesity status. They also suggest that MCH is not necessary for the TLR4-dependent immune response triggered by the high-fat diet. SN - 1468-3288 UR - https://www.unboundmedicine.com/medline/citation/20966023/You_deserve_what_you_eat:_lessons_learned_from_the_study_of_the_melanin_concentrating_hormone__MCH__deficient_mice_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&pmid=20966023 DB - PRIME DP - Unbound Medicine ER -