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Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk.
Pancreas. 2011 Jan; 40(1):72-8.P

Abstract

OBJECTIVES

Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied.

METHODS

Polymorphisms were studied by allelic discrimination.

RESULTS

In a hospital-based case-control study on 500 individuals (235 cases and 265 controls) of Czech white origin, SOD2, SOD3, NQO1, and NQO2 polymorphisms showed no significant association with pancreatic cancer risk. Major lifestyle factors such as smoking and alcohol, coffee, or tea consumption did not modify the effect of the studied polymorphisms.

CONCLUSIONS

The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. Despite this observation, other populations with different lifestyle(s) may be at risk and should be further studied.

Authors+Show Affiliations

Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20966810

Citation

Mohelnikova-Duchonova, Beatrice, et al. "Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate: Quinone Oxidoreductase Polymorphisms and Pancreatic Cancer Risk." Pancreas, vol. 40, no. 1, 2011, pp. 72-8.
Mohelnikova-Duchonova B, Marsakova L, Vrana D, et al. Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk. Pancreas. 2011;40(1):72-8.
Mohelnikova-Duchonova, B., Marsakova, L., Vrana, D., Holcatova, I., Ryska, M., Smerhovsky, Z., Slamova, A., Schejbalova, M., & Soucek, P. (2011). Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk. Pancreas, 40(1), 72-8. https://doi.org/10.1097/MPA.0b013e3181f74ad7
Mohelnikova-Duchonova B, et al. Superoxide Dismutase and Nicotinamide Adenine Dinucleotide Phosphate: Quinone Oxidoreductase Polymorphisms and Pancreatic Cancer Risk. Pancreas. 2011;40(1):72-8. PubMed PMID: 20966810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superoxide dismutase and nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase polymorphisms and pancreatic cancer risk. AU - Mohelnikova-Duchonova,Beatrice, AU - Marsakova,Lenka, AU - Vrana,David, AU - Holcatova,Ivana, AU - Ryska,Miroslav, AU - Smerhovsky,Zdenek, AU - Slamova,Alena, AU - Schejbalova,Miriam, AU - Soucek,Pavel, PY - 2010/10/23/entrez PY - 2010/10/23/pubmed PY - 2011/4/19/medline SP - 72 EP - 8 JF - Pancreas JO - Pancreas VL - 40 IS - 1 N2 - OBJECTIVES: Pancreatic carcinoma etiology and molecular pathogenesis is weakly understood. According to the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, an association of functional polymorphisms in oxidative stress-modifying genes superoxide dismutase 2 (SOD2 [Ala16Val, rs4880]), SOD3 (Arg231Gly, rs1799895), nicotinamide adenine dinucleotide phosphate:quinone oxidoreductase (NQO1 [Pro187Ser, rs1800566], and NQO2 (Phe47Leu, rs1143684) with pancreatic cancer risk was studied. METHODS: Polymorphisms were studied by allelic discrimination. RESULTS: In a hospital-based case-control study on 500 individuals (235 cases and 265 controls) of Czech white origin, SOD2, SOD3, NQO1, and NQO2 polymorphisms showed no significant association with pancreatic cancer risk. Major lifestyle factors such as smoking and alcohol, coffee, or tea consumption did not modify the effect of the studied polymorphisms. CONCLUSIONS: The first European study of the SOD2, SOD3, NQO1, and NQO2 roles in pancreatic cancer etiology did not find significant associations. Despite this observation, other populations with different lifestyle(s) may be at risk and should be further studied. SN - 1536-4828 UR - https://www.unboundmedicine.com/medline/citation/20966810/Superoxide_dismutase_and_nicotinamide_adenine_dinucleotide_phosphate:_quinone_oxidoreductase_polymorphisms_and_pancreatic_cancer_risk_ L2 - https://doi.org/10.1097/MPA.0b013e3181f74ad7 DB - PRIME DP - Unbound Medicine ER -