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Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities.
Molecules. 2010 Oct 22; 15(10):7438-49.M

Abstract

Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC₅₀ value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC₅₀ value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds.

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Authors+Show Affiliations

Chen Y
Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China.
Fan H
No affiliation info available
Yang GZ
No affiliation info available
Jiang Y
No affiliation info available
Zhong FF
No affiliation info available
He HW
No affiliation info available

MeSH

Biphenyl CompoundsFree Radical ScavengersFree RadicalsGarciniaHumansIndicators and ReagentsMedicine, Chinese TraditionalMolecular StructurePicratesPlant BarkPlant ExtractsPrenylationXanthones

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20966883

Citation

Chen, Yu, et al. "Prenylated Xanthones From the Bark of Garcinia Xanthochymus and Their 1,1-diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities." Molecules (Basel, Switzerland), vol. 15, no. 10, 2010, pp. 7438-49.
Chen Y, Fan H, Yang GZ, et al. Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Molecules. 2010;15(10):7438-49.
Chen, Y., Fan, H., Yang, G. Z., Jiang, Y., Zhong, F. F., & He, H. W. (2010). Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. Molecules (Basel, Switzerland), 15(10), 7438-49. https://doi.org/10.3390/molecules15107438
Chen Y, et al. Prenylated Xanthones From the Bark of Garcinia Xanthochymus and Their 1,1-diphenyl-2-picrylhydrazyl (DPPH) Radical Scavenging Activities. Molecules. 2010 Oct 22;15(10):7438-49. PubMed PMID: 20966883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenylated xanthones from the bark of Garcinia xanthochymus and their 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities. AU - Chen,Yu, AU - Fan,Hua, AU - Yang,Guang-Zhong, AU - Jiang,Yan, AU - Zhong,Fang-Fang, AU - He,Hong-Wu, Y1 - 2010/10/22/ PY - 2010/09/25/received PY - 2010/10/07/revised PY - 2010/10/11/accepted PY - 2010/10/23/entrez PY - 2010/10/23/pubmed PY - 2011/2/5/medline SP - 7438 EP - 49 JF - Molecules (Basel, Switzerland) JO - Molecules VL - 15 IS - 10 N2 - Garcinia xanthochymus has been widely used in traditional Chinese medicine for expelling worms and removing food toxins. Bioassay-guided fractionation of an EtOAc-soluble extract of G. xanthochymus stem bark led to the isolation of six new xanthones. Their structures were elucidated by spectroscopic methods, especially 2D-NMR techniques. Free-radical-scavenging activities of the isolated compounds were elucidated through DPPH method. Most of the isolated compounds showed considerable free radical scavenging activity on DPPH assay. Compound 1 exhibited effective antioxidant scavenging activity against DPPH radical with an IC₅₀ value of 19.64 μM, and compound 6 showed the lowest activity among all the tested molecules, with an IC₅₀ value of 66.88 μM. These findings support the notion that the plant genus Garcinia is a good source of bioactive compounds. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/20966883/Prenylated_xanthones_from_the_bark_of_Garcinia_xanthochymus_and_their_11_diphenyl_2_picrylhydrazyl__DPPH__radical_scavenging_activities_ L2 - https://www.mdpi.com/resolver?pii=molecules15107438 DB - PRIME DP - Unbound Medicine ER -