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Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease.
Acta Neurol Scand. 2011 Sep; 124(3):211-4.AN

Abstract

OBJECTIVE

To compare the medication dose reduction between deep brain stimulation (DBS) of the globus pallidus interna (GPi) vs subthalamic nucleus (STN) in matched patients with Parkinson's disease (PD).

MATERIALS AND METHODS

Records of 12 patients with PD who underwent GPi-DBS at our institution from 2002 to 2008 were matched by pre-operative PD medication doses and pre-operative motor Unified Parkinson's Disease Rating Scale (UPDRS) scores to 12 cases of STN-DBS. PD medication doses were converted to levodopa equivalent doses (LEDs).

RESULTS

GPi and STN groups had similar mean pre-operative LEDs and motor UPDRS scores. At 6 months post-DBS, there was no significant difference in percent reduction in LEDs between the GPi (47.95%) and STN (37.47%) groups (P = 0.52). The mean post-operative 'medication off/stimulation on' motor UPDRS scores did not differ significantly between GPi (15.33) and STN (16.25) groups (P = 0.74). The mean percent reduction in motor UPDRS scores was also similar between GPi (58.44%) and STN (58.98%) patients (P = 0.94).

CONCLUSIONS

We conclude that in disease-matched patients with PD undergoing DBS, both GPi and STN may result in similar reduction in PD medication doses.

Authors+Show Affiliations

Department of Neurology Department of Neurological Surgery, Mayo Clinic Arizona, Scottsdale, AZ 85259, USA. evidente.virgilio@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20969559

Citation

Evidente, V G H., et al. "Medication Dose Reductions After Pallidal Versus Subthalamic Stimulation in Patients With Parkinson's Disease." Acta Neurologica Scandinavica, vol. 124, no. 3, 2011, pp. 211-4.
Evidente VG, Premkumar AP, Adler CH, et al. Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease. Acta Neurol Scand. 2011;124(3):211-4.
Evidente, V. G., Premkumar, A. P., Adler, C. H., Caviness, J. N., Driver-Dunckley, E., & Lyons, M. K. (2011). Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease. Acta Neurologica Scandinavica, 124(3), 211-4. https://doi.org/10.1111/j.1600-0404.2010.01455.x
Evidente VG, et al. Medication Dose Reductions After Pallidal Versus Subthalamic Stimulation in Patients With Parkinson's Disease. Acta Neurol Scand. 2011;124(3):211-4. PubMed PMID: 20969559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medication dose reductions after pallidal versus subthalamic stimulation in patients with Parkinson's disease. AU - Evidente,V G H, AU - Premkumar,A P, AU - Adler,C H, AU - Caviness,J N, AU - Driver-Dunckley,E, AU - Lyons,M K, Y1 - 2010/10/25/ PY - 2010/10/26/entrez PY - 2010/10/26/pubmed PY - 2012/5/30/medline SP - 211 EP - 4 JF - Acta neurologica Scandinavica JO - Acta Neurol Scand VL - 124 IS - 3 N2 - OBJECTIVE: To compare the medication dose reduction between deep brain stimulation (DBS) of the globus pallidus interna (GPi) vs subthalamic nucleus (STN) in matched patients with Parkinson's disease (PD). MATERIALS AND METHODS: Records of 12 patients with PD who underwent GPi-DBS at our institution from 2002 to 2008 were matched by pre-operative PD medication doses and pre-operative motor Unified Parkinson's Disease Rating Scale (UPDRS) scores to 12 cases of STN-DBS. PD medication doses were converted to levodopa equivalent doses (LEDs). RESULTS: GPi and STN groups had similar mean pre-operative LEDs and motor UPDRS scores. At 6 months post-DBS, there was no significant difference in percent reduction in LEDs between the GPi (47.95%) and STN (37.47%) groups (P = 0.52). The mean post-operative 'medication off/stimulation on' motor UPDRS scores did not differ significantly between GPi (15.33) and STN (16.25) groups (P = 0.74). The mean percent reduction in motor UPDRS scores was also similar between GPi (58.44%) and STN (58.98%) patients (P = 0.94). CONCLUSIONS: We conclude that in disease-matched patients with PD undergoing DBS, both GPi and STN may result in similar reduction in PD medication doses. SN - 1600-0404 UR - https://www.unboundmedicine.com/medline/citation/20969559/Medication_dose_reductions_after_pallidal_versus_subthalamic_stimulation_in_patients_with_Parkinson's_disease_ L2 - https://doi.org/10.1111/j.1600-0404.2010.01455.x DB - PRIME DP - Unbound Medicine ER -