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Tick-borne encephalitis: pathogenesis and clinical implications.
Travel Med Infect Dis 2010; 8(4):223-32TM

Abstract

Tick-borne encephalitis (TBE) is an important and severe neurological illness occurring in large areas of Europe and northern Asia. Only a small proportion of those infected develop clinical symptoms. The symptomatic cases are, however, characterized with fevers and debilitating encephalitis that might progress into chronic disease or fatal infections. This review summarizes data on clinical presentation, pathogenesis and pathology of TBE in humans, and of experimental TBE in animal models with the purpose to explain why is TBE such a severe disease clinically.

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    Authors+Show Affiliations

    Růžek D
    Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic, Branišovská 31, CZ-37005 České Budějovice, Czech Republic. ruzekd@paru.cas.cz
    Dobler G
    No affiliation info available
    Donoso Mantke O
    No affiliation info available

    MeSH

    AdultAnimalsChildDisease Models, AnimalEncephalitis Viruses, Tick-BorneEncephalitis, Tick-BorneHumansIxodesMiceViral Vaccines

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    20970725

    Citation

    Růžek, Daniel, et al. "Tick-borne Encephalitis: Pathogenesis and Clinical Implications." Travel Medicine and Infectious Disease, vol. 8, no. 4, 2010, pp. 223-32.
    Růžek D, Dobler G, Donoso Mantke O. Tick-borne encephalitis: pathogenesis and clinical implications. Travel Med Infect Dis. 2010;8(4):223-32.
    Růžek, D., Dobler, G., & Donoso Mantke, O. (2010). Tick-borne encephalitis: pathogenesis and clinical implications. Travel Medicine and Infectious Disease, 8(4), pp. 223-32. doi:10.1016/j.tmaid.2010.06.004.
    Růžek D, Dobler G, Donoso Mantke O. Tick-borne Encephalitis: Pathogenesis and Clinical Implications. Travel Med Infect Dis. 2010;8(4):223-32. PubMed PMID: 20970725.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Tick-borne encephalitis: pathogenesis and clinical implications. AU - Růžek,Daniel, AU - Dobler,Gerhard, AU - Donoso Mantke,Oliver, Y1 - 2010/07/21/ PY - 2010/05/17/received PY - 2010/06/07/revised PY - 2010/06/28/accepted PY - 2010/10/26/entrez PY - 2010/10/26/pubmed PY - 2011/2/23/medline SP - 223 EP - 32 JF - Travel medicine and infectious disease JO - Travel Med Infect Dis VL - 8 IS - 4 N2 - Tick-borne encephalitis (TBE) is an important and severe neurological illness occurring in large areas of Europe and northern Asia. Only a small proportion of those infected develop clinical symptoms. The symptomatic cases are, however, characterized with fevers and debilitating encephalitis that might progress into chronic disease or fatal infections. This review summarizes data on clinical presentation, pathogenesis and pathology of TBE in humans, and of experimental TBE in animal models with the purpose to explain why is TBE such a severe disease clinically. SN - 1873-0442 UR - https://www.unboundmedicine.com/medline/citation/20970725/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1477-8939(10)00101-8 DB - PRIME DP - Unbound Medicine ER -