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Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus.
Auris Nasus Larynx. 2011 Jun; 38(3):301-6.AN

Abstract

OBJECTIVE

There is compelling evidence that tinnitus is associated with functional alterations in the central nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a potent tool for modifying neural activity at the stimulated area and at a distance along the functional anatomical connections. Depending on the stimulation parameters, cortical networks can be functionally disturbed or modulated in their activities. Low-frequency rTMS has been shown to result in a decrease in cortical excitability. The technique can alleviate tinnitus by modulating the excitability of neurons in the auditory cortex. We aimed to investigate the effects of low-frequency rTMS in patients and determine the factors that predict a beneficial outcome with rTMS treatment.

METHODS

Sixteen patients (male 10, female 6) with chronic tinnitus underwent low-frequency (1Hz) rTMS (intensity: 110% motor threshold; number of stimuli: 1200) to the left auditory cortex. The treatment outcome was assessed with a visual analog scale (VAS) of loudness, annoyance and duration, loudness balance test, and tinnitus handicap inventory (THI). Therapeutic success was studied according to the patients' clinical characteristics.

RESULTS

A significant reduction in the VAS (loudness and annoyance) occurred immediately after rTMS, with a gradual return to pretreatment levels after 7 days. The tinnitus patients with sudden deafness were significant resistant to rTMS treatment compared with those diagnosed with age-related hearing loss.

CONCLUSION

These results support the potential of rTMS as a new therapeutic tool for the treatment of chronic tinnitus. Because this study was performed with a small sample size and showed high interindividual variability in treatment effects, further development of the technique is needed before it can be recommended for clinical applications.

Authors+Show Affiliations

National Institute of Sensory Organs, National Tokyo Medical Center, 2-5-1 Higashigaoka, Tokyo, Japan. shujirominami@mac.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20971587

Citation

Minami, Shujiro B., et al. "Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Chronic Tinnitus." Auris, Nasus, Larynx, vol. 38, no. 3, 2011, pp. 301-6.
Minami SB, Shinden S, Okamoto Y, et al. Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. Auris Nasus Larynx. 2011;38(3):301-6.
Minami, S. B., Shinden, S., Okamoto, Y., Watada, Y., Watabe, T., Oishi, N., Kanzaki, S., Saito, H., Inoue, Y., & Ogawa, K. (2011). Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. Auris, Nasus, Larynx, 38(3), 301-6. https://doi.org/10.1016/j.anl.2010.09.007
Minami SB, et al. Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Chronic Tinnitus. Auris Nasus Larynx. 2011;38(3):301-6. PubMed PMID: 20971587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus. AU - Minami,Shujiro B, AU - Shinden,Seiichi, AU - Okamoto,Yasuhide, AU - Watada,Yukiko, AU - Watabe,Takahisa, AU - Oishi,Naoki, AU - Kanzaki,Sho, AU - Saito,Hideyuki, AU - Inoue,Yasuhiro, AU - Ogawa,Kaoru, Y1 - 2010/10/23/ PY - 2010/07/21/received PY - 2010/08/24/revised PY - 2010/09/09/accepted PY - 2010/10/26/entrez PY - 2010/10/26/pubmed PY - 2011/8/5/medline SP - 301 EP - 6 JF - Auris, nasus, larynx JO - Auris Nasus Larynx VL - 38 IS - 3 N2 - OBJECTIVE: There is compelling evidence that tinnitus is associated with functional alterations in the central nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a potent tool for modifying neural activity at the stimulated area and at a distance along the functional anatomical connections. Depending on the stimulation parameters, cortical networks can be functionally disturbed or modulated in their activities. Low-frequency rTMS has been shown to result in a decrease in cortical excitability. The technique can alleviate tinnitus by modulating the excitability of neurons in the auditory cortex. We aimed to investigate the effects of low-frequency rTMS in patients and determine the factors that predict a beneficial outcome with rTMS treatment. METHODS: Sixteen patients (male 10, female 6) with chronic tinnitus underwent low-frequency (1Hz) rTMS (intensity: 110% motor threshold; number of stimuli: 1200) to the left auditory cortex. The treatment outcome was assessed with a visual analog scale (VAS) of loudness, annoyance and duration, loudness balance test, and tinnitus handicap inventory (THI). Therapeutic success was studied according to the patients' clinical characteristics. RESULTS: A significant reduction in the VAS (loudness and annoyance) occurred immediately after rTMS, with a gradual return to pretreatment levels after 7 days. The tinnitus patients with sudden deafness were significant resistant to rTMS treatment compared with those diagnosed with age-related hearing loss. CONCLUSION: These results support the potential of rTMS as a new therapeutic tool for the treatment of chronic tinnitus. Because this study was performed with a small sample size and showed high interindividual variability in treatment effects, further development of the technique is needed before it can be recommended for clinical applications. SN - 1879-1476 UR - https://www.unboundmedicine.com/medline/citation/20971587/Repetitive_transcranial_magnetic_stimulation__rTMS__for_treatment_of_chronic_tinnitus_ DB - PRIME DP - Unbound Medicine ER -