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Impairment of cardiorespiratory reflexes and its association with distal somatic neuropathy in diabetic patients free from clinical symptoms of autonomic neuropathy.
Exp Clin Endocrinol. 1990 Nov; 96(2):199-206.EC

Abstract

Signs of autonomic cardiac neuropathy and its association with distal somatic neuropathy were investigated in 36 type 1 and 28 type 2 diabetic patients free from clinical symptoms of autonomic neuropathy. Using bedside tests (deep-breathing, Valsalva manoeuvre and lying-to-standing) definitive cardiac autonomic neuropathy was found in 28 patients (44%), early cardiac autonomic neuropathy was observed in 19 patients (30%) while 17 patients (26%) showed no alterations. The values of motor nerve conduction velocity in peroneal nerves (41.8 +/- 0.7 m/s, mean +/- SEM) were significantly (p less than 0.01) lower in patients with definitive cardiac autonomic neuropathy than those (45.8 +/- 1.1 m/s) of patients without any signs of cardiac autonomic neuropathy. These latter values were, however, significantly (p less than 0.001) lower than those (53.7 +/- 0.7 m/s) of control subjects (n = 50). Signs of early or definitive cardiac autonomic neuropathy were recorded in 31 of 35 diabetic patients with distal somatic neuropathy assessed by measurement of motor nerve conduction velocity in peroneal nerves. It was concluded that abnormal results of noninvasive tests for autonomic neuropathy, i.e. alterations in cardiorespiratory reflexes indicating parasympathetic impairment of cardiac innervation could be often found in diabetic patients without clinical signs of autonomic neuropathy. These alterations could be frequently observed in diabetic patients with distal symmetrical somatic neuropathy.

Authors+Show Affiliations

István Municipal Hospital, Merényi Medical Department, Budapest/Hungary.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2097165

Citation

Jermendy, G, et al. "Impairment of Cardiorespiratory Reflexes and Its Association With Distal Somatic Neuropathy in Diabetic Patients Free From Clinical Symptoms of Autonomic Neuropathy." Experimental and Clinical Endocrinology, vol. 96, no. 2, 1990, pp. 199-206.
Jermendy G, Tóth L, Vörös P, et al. Impairment of cardiorespiratory reflexes and its association with distal somatic neuropathy in diabetic patients free from clinical symptoms of autonomic neuropathy. Exp Clin Endocrinol. 1990;96(2):199-206.
Jermendy, G., Tóth, L., Vörös, P., Király, M., Perényi, J., Kammerer, L., & Pogátsa, G. (1990). Impairment of cardiorespiratory reflexes and its association with distal somatic neuropathy in diabetic patients free from clinical symptoms of autonomic neuropathy. Experimental and Clinical Endocrinology, 96(2), 199-206.
Jermendy G, et al. Impairment of Cardiorespiratory Reflexes and Its Association With Distal Somatic Neuropathy in Diabetic Patients Free From Clinical Symptoms of Autonomic Neuropathy. Exp Clin Endocrinol. 1990;96(2):199-206. PubMed PMID: 2097165.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impairment of cardiorespiratory reflexes and its association with distal somatic neuropathy in diabetic patients free from clinical symptoms of autonomic neuropathy. AU - Jermendy,G, AU - Tóth,L, AU - Vörös,P, AU - Király,M, AU - Perényi,J, AU - Kammerer,L, AU - Pogátsa,G, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 199 EP - 206 JF - Experimental and clinical endocrinology JO - Exp Clin Endocrinol VL - 96 IS - 2 N2 - Signs of autonomic cardiac neuropathy and its association with distal somatic neuropathy were investigated in 36 type 1 and 28 type 2 diabetic patients free from clinical symptoms of autonomic neuropathy. Using bedside tests (deep-breathing, Valsalva manoeuvre and lying-to-standing) definitive cardiac autonomic neuropathy was found in 28 patients (44%), early cardiac autonomic neuropathy was observed in 19 patients (30%) while 17 patients (26%) showed no alterations. The values of motor nerve conduction velocity in peroneal nerves (41.8 +/- 0.7 m/s, mean +/- SEM) were significantly (p less than 0.01) lower in patients with definitive cardiac autonomic neuropathy than those (45.8 +/- 1.1 m/s) of patients without any signs of cardiac autonomic neuropathy. These latter values were, however, significantly (p less than 0.001) lower than those (53.7 +/- 0.7 m/s) of control subjects (n = 50). Signs of early or definitive cardiac autonomic neuropathy were recorded in 31 of 35 diabetic patients with distal somatic neuropathy assessed by measurement of motor nerve conduction velocity in peroneal nerves. It was concluded that abnormal results of noninvasive tests for autonomic neuropathy, i.e. alterations in cardiorespiratory reflexes indicating parasympathetic impairment of cardiac innervation could be often found in diabetic patients without clinical signs of autonomic neuropathy. These alterations could be frequently observed in diabetic patients with distal symmetrical somatic neuropathy. SN - 0232-7384 UR - https://www.unboundmedicine.com/medline/citation/2097165/Impairment_of_cardiorespiratory_reflexes_and_its_association_with_distal_somatic_neuropathy_in_diabetic_patients_free_from_clinical_symptoms_of_autonomic_neuropathy_ DB - PRIME DP - Unbound Medicine ER -