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The effect of D-cycloserine on immediate vs. delayed extinction of learned fear.
Learn Mem. 2010 Nov; 17(11):547-51.LM

Abstract

We compared the effect of D-cycloserine (DCS) on immediate (10 min after conditioning) and delayed (24 h after conditioning) extinction of learned fear in rats. DCS facilitated both immediate and delayed extinction when the drug was administered after extinction training. However, DCS did not facilitate immediate extinction when administered prior to extinction training (i.e., when the interval between drug administration and shock was reduced). In addition, administering five, but not two, shocks prior to extinction training disrupted the facilitating effects of DCS on delayed extinction. These results suggest that aversive experiences prior to DCS administration can prevent it from facilitating extinction.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Langton JM
Adult Cancer Program, Prince of Wales Clinical School, University of New South Wales, Sydney 2052, Australia. j.langton@unsw.edu.au
Richardson R
No affiliation info available

MeSH

AnimalsAntimetabolitesConditioning, ClassicalCycloserineElectroshockExtinction, PsychologicalFearRatsTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20971937

Citation

Langton, Julia M., and Rick Richardson. "The Effect of D-cycloserine On Immediate Vs. Delayed Extinction of Learned Fear." Learning & Memory (Cold Spring Harbor, N.Y.), vol. 17, no. 11, 2010, pp. 547-51.
Langton JM, Richardson R. The effect of D-cycloserine on immediate vs. delayed extinction of learned fear. Learn Mem. 2010;17(11):547-51.
Langton, J. M., & Richardson, R. (2010). The effect of D-cycloserine on immediate vs. delayed extinction of learned fear. Learning & Memory (Cold Spring Harbor, N.Y.), 17(11), 547-51. https://doi.org/10.1101/lm.1927310
Langton JM, Richardson R. The Effect of D-cycloserine On Immediate Vs. Delayed Extinction of Learned Fear. Learn Mem. 2010;17(11):547-51. PubMed PMID: 20971937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of D-cycloserine on immediate vs. delayed extinction of learned fear. AU - Langton,Julia M, AU - Richardson,Rick, Y1 - 2010/10/22/ PY - 2010/10/26/entrez PY - 2010/10/26/pubmed PY - 2011/2/12/medline SP - 547 EP - 51 JF - Learning & memory (Cold Spring Harbor, N.Y.) JO - Learn Mem VL - 17 IS - 11 N2 - We compared the effect of D-cycloserine (DCS) on immediate (10 min after conditioning) and delayed (24 h after conditioning) extinction of learned fear in rats. DCS facilitated both immediate and delayed extinction when the drug was administered after extinction training. However, DCS did not facilitate immediate extinction when administered prior to extinction training (i.e., when the interval between drug administration and shock was reduced). In addition, administering five, but not two, shocks prior to extinction training disrupted the facilitating effects of DCS on delayed extinction. These results suggest that aversive experiences prior to DCS administration can prevent it from facilitating extinction. SN - 1549-5485 UR - https://www.unboundmedicine.com/medline/citation/20971937/The_effect_of_D_cycloserine_on_immediate_vs__delayed_extinction_of_learned_fear_ DB - PRIME DP - Unbound Medicine ER -