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Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function.
Eur J Clin Microbiol Infect Dis. 2011 Mar; 30(3):381-5.EJ

Abstract

Dobrava (DOBV) and Puumala (PUUV) viruses are endemic throughout the Balkans and cause haemorrhagic fever with renal syndrome (HFRS). The aim of this study was to assess the impact of two different hantaviruses on renal function in HFRS patients during the acute stage of illness. We also aimed to assess the DOBV and PUUV distribution between symptomatic HFRS patients and asymptomatic hantavirus antibody-positive subjects. The study included 264 symptomatic HFRS patients and 63 asymptomatic hantavirus antibody-positive healthy subjects. In our study, 131 (49.6%) HFRS patients were regarded as PUUV- and 69 (26.1%) as DOBV-infected patients, while in 64 (24.2%) of HFRS patients that showed all clinical and biochemical signs of HFRS, the causal hantavirus could not be determined with commercially available tests. DOBV-infected patients were associated with more requirements for haemodialysis treatment, lower diuresis and higher serum creatinine and urea values compared to PUUV-infected patients. PUUV was significantly predominant in asymptomatic hantavirus antibody-positive subjects (69.8%) compared to HFRS patients. DOBV was present in 17.5% of asymptomatic subjects and, interestingly, the preferential hantavirus serotype could not be determined in 12.7% of the asymptomatic antibody-positive subjects.

Authors+Show Affiliations

Institute of Clinical Microbiology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20972691

Citation

Hukić, M, et al. "Pathogenicity and Virulence of the Present Hantaviruses in Bosnia and Herzegovina: the Impact On Renal Function." European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, vol. 30, no. 3, 2011, pp. 381-5.
Hukić M, Valjevac A, Tulumovic D, et al. Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function. Eur J Clin Microbiol Infect Dis. 2011;30(3):381-5.
Hukić, M., Valjevac, A., Tulumovic, D., Numanovic, F., & Heyman, P. (2011). Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function. European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology, 30(3), 381-5. https://doi.org/10.1007/s10096-010-1097-6
Hukić M, et al. Pathogenicity and Virulence of the Present Hantaviruses in Bosnia and Herzegovina: the Impact On Renal Function. Eur J Clin Microbiol Infect Dis. 2011;30(3):381-5. PubMed PMID: 20972691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function. AU - Hukić,M, AU - Valjevac,A, AU - Tulumovic,D, AU - Numanovic,F, AU - Heyman,P, Y1 - 2010/10/23/ PY - 2010/06/18/received PY - 2010/10/08/accepted PY - 2010/10/26/entrez PY - 2010/10/26/pubmed PY - 2011/8/17/medline SP - 381 EP - 5 JF - European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology JO - Eur. J. Clin. Microbiol. Infect. Dis. VL - 30 IS - 3 N2 - Dobrava (DOBV) and Puumala (PUUV) viruses are endemic throughout the Balkans and cause haemorrhagic fever with renal syndrome (HFRS). The aim of this study was to assess the impact of two different hantaviruses on renal function in HFRS patients during the acute stage of illness. We also aimed to assess the DOBV and PUUV distribution between symptomatic HFRS patients and asymptomatic hantavirus antibody-positive subjects. The study included 264 symptomatic HFRS patients and 63 asymptomatic hantavirus antibody-positive healthy subjects. In our study, 131 (49.6%) HFRS patients were regarded as PUUV- and 69 (26.1%) as DOBV-infected patients, while in 64 (24.2%) of HFRS patients that showed all clinical and biochemical signs of HFRS, the causal hantavirus could not be determined with commercially available tests. DOBV-infected patients were associated with more requirements for haemodialysis treatment, lower diuresis and higher serum creatinine and urea values compared to PUUV-infected patients. PUUV was significantly predominant in asymptomatic hantavirus antibody-positive subjects (69.8%) compared to HFRS patients. DOBV was present in 17.5% of asymptomatic subjects and, interestingly, the preferential hantavirus serotype could not be determined in 12.7% of the asymptomatic antibody-positive subjects. SN - 1435-4373 UR - https://www.unboundmedicine.com/medline/citation/20972691/Pathogenicity_and_virulence_of_the_present_hantaviruses_in_Bosnia_and_Herzegovina:_the_impact_on_renal_function_ L2 - https://dx.doi.org/10.1007/s10096-010-1097-6 DB - PRIME DP - Unbound Medicine ER -