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Hypocalcemic seizures in breastfed infants with rickets secondary to severe maternal vitamin D deficiency.
Pak J Biol Sci 2010; 13(9):437-42PJ

Abstract

This study was done to evaluate if nursing mothers of infants with rickets have vitamin D deficiency, and to evaluate the relationship between maternal vitamin D levels with hypocalcemic seizures in infants with rickets. We selected a cohort of breastfed infants with rickets. Infants were included in this study if they were breastfed and presented with any of the following clinical criteria: delayed motor milestones or delayed teething, were found to have specific rachitic bony signs, or presented with hypocalcemic seizures. We checked serum calcium (Ca), phosphorus (P), alkaline phosphatase, 25 hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH) levels in both infants and their mothers. Out of 32 children who met the clinical criteria for rickets, 23 (72%) had vitamin D level less than 20 ng mL(-1). Twenty two mothers (69%) had vitamin D deficiency (25 hydroxy vitamin D < 20 ng mL(-1)). Mothers of nine infants who presented with hypocalcemic seizures had severe vitamin D deficiency, (p = 0.005). We conclude that maternal vitamin D deficiency is common in nursing mothers of infants diagnosed with rickets. Invariably mothers of infants presenting with hypocalcemic seizures have severe vitamin D deficiency. Hypocalcemic seizures in infants secondary to maternal vitamin D deficiency might be prevented by supplementation of vitamin D.

Authors+Show Affiliations

Department of Obstetric and Gynecology, Ain Shams University, Egypt.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20973397

Citation

Salama, Mostafa M., and Abeer S. El-Sakka. "Hypocalcemic Seizures in Breastfed Infants With Rickets Secondary to Severe Maternal Vitamin D Deficiency." Pakistan Journal of Biological Sciences : PJBS, vol. 13, no. 9, 2010, pp. 437-42.
Salama MM, El-Sakka AS. Hypocalcemic seizures in breastfed infants with rickets secondary to severe maternal vitamin D deficiency. Pak J Biol Sci. 2010;13(9):437-42.
Salama, M. M., & El-Sakka, A. S. (2010). Hypocalcemic seizures in breastfed infants with rickets secondary to severe maternal vitamin D deficiency. Pakistan Journal of Biological Sciences : PJBS, 13(9), pp. 437-42.
Salama MM, El-Sakka AS. Hypocalcemic Seizures in Breastfed Infants With Rickets Secondary to Severe Maternal Vitamin D Deficiency. Pak J Biol Sci. 2010 May 1;13(9):437-42. PubMed PMID: 20973397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypocalcemic seizures in breastfed infants with rickets secondary to severe maternal vitamin D deficiency. AU - Salama,Mostafa M, AU - El-Sakka,Abeer S, PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2010/11/10/medline SP - 437 EP - 42 JF - Pakistan journal of biological sciences : PJBS JO - Pak. J. Biol. Sci. VL - 13 IS - 9 N2 - This study was done to evaluate if nursing mothers of infants with rickets have vitamin D deficiency, and to evaluate the relationship between maternal vitamin D levels with hypocalcemic seizures in infants with rickets. We selected a cohort of breastfed infants with rickets. Infants were included in this study if they were breastfed and presented with any of the following clinical criteria: delayed motor milestones or delayed teething, were found to have specific rachitic bony signs, or presented with hypocalcemic seizures. We checked serum calcium (Ca), phosphorus (P), alkaline phosphatase, 25 hydroxy vitamin D [25(OH)D] and parathyroid hormone (PTH) levels in both infants and their mothers. Out of 32 children who met the clinical criteria for rickets, 23 (72%) had vitamin D level less than 20 ng mL(-1). Twenty two mothers (69%) had vitamin D deficiency (25 hydroxy vitamin D < 20 ng mL(-1)). Mothers of nine infants who presented with hypocalcemic seizures had severe vitamin D deficiency, (p = 0.005). We conclude that maternal vitamin D deficiency is common in nursing mothers of infants diagnosed with rickets. Invariably mothers of infants presenting with hypocalcemic seizures have severe vitamin D deficiency. Hypocalcemic seizures in infants secondary to maternal vitamin D deficiency might be prevented by supplementation of vitamin D. SN - 1028-8880 UR - https://www.unboundmedicine.com/medline/citation/20973397/Hypocalcemic_seizures_in_breastfed_infants_with_rickets_secondary_to_severe_maternal_vitamin_D_deficiency_ L2 - http://www.diseaseinfosearch.org/result/6489 DB - PRIME DP - Unbound Medicine ER -