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Experimental investigation of needles, syringes and techniques for intravitreal injections.
Clin Exp Ophthalmol. 2011 Apr; 39(3):236-42.CE

Abstract

BACKGROUND

To assess the techniques and materials used in intravitreal injections.

DESIGN

Descriptive study realized at the Vision Institute of the Federal University of São Paulo, Brazil.

SAMPLES

Different brands of needles and syringes, as well as enucleated porcine eyeballs.

METHODS

The ultra-structures of commonly used needles were analysed by scanning electron microscope, and they were compared using different criteria, such as irregularities and debris from the lubrication process. The scleral incision was also assessed using needles of different brands and sizes. Accuracies in drug administration were studied by comparing the residual and delivered volume of needles and also by the analysis of reflux after intravitreal injections.

MAIN OUTCOME MEASURES

Efficiency and quality of materials used in intravitreal injections.

RESULTS

Ultra-structure analyses showed that all needles had different types of irregularities. Some photographs showed debris from the lubrication process, especially in BD needles. Scleral incision analysis showed a tendency of reducing the ocular damage with increasing gauge (P=0.024). The investigation of delivery accuracy showed that almost all needles underdosed the amount injected (P<0.05), and that the reflux could be minimized by tunnelled injections with thinner needles.

CONCLUSION

Needles used in intravitreal injections possess many irregularities in their structures, which may cause different injection outcomes. Analyses of scleral incisions showed that the larger the needle gauge, the lesser the scleral damage and the risk of complications. Moreover, drug administration inaccuracies might be one of the causes for some unsuccessful attempts of treatment.

Authors+Show Affiliations

Vision Institute - IPEPO, Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil. vsstefano@uol.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20973898

Citation

De Stefano, Vinicius S., et al. "Experimental Investigation of Needles, Syringes and Techniques for Intravitreal Injections." Clinical & Experimental Ophthalmology, vol. 39, no. 3, 2011, pp. 236-42.
De Stefano VS, Abechain JJ, de Almeida LF, et al. Experimental investigation of needles, syringes and techniques for intravitreal injections. Clin Experiment Ophthalmol. 2011;39(3):236-42.
De Stefano, V. S., Abechain, J. J., de Almeida, L. F., Verginassi, D. M., Rodrigues, E. B., Freymuller, E., Maia, M., Magalhaes, O., Nguyen, Q. D., & Farah, M. E. (2011). Experimental investigation of needles, syringes and techniques for intravitreal injections. Clinical & Experimental Ophthalmology, 39(3), 236-42. https://doi.org/10.1111/j.1442-9071.2010.02447.x
De Stefano VS, et al. Experimental Investigation of Needles, Syringes and Techniques for Intravitreal Injections. Clin Experiment Ophthalmol. 2011;39(3):236-42. PubMed PMID: 20973898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Experimental investigation of needles, syringes and techniques for intravitreal injections. AU - De Stefano,Vinicius S, AU - Abechain,Jose Jk, AU - de Almeida,Luiz Fs, AU - Verginassi,Diego M, AU - Rodrigues,Eduardo B, AU - Freymuller,Edna, AU - Maia,Maurício, AU - Magalhaes,Octaviano, AU - Nguyen,Quan D, AU - Farah,Michel E, PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2011/6/18/medline SP - 236 EP - 42 JF - Clinical & experimental ophthalmology JO - Clin. Experiment. Ophthalmol. VL - 39 IS - 3 N2 - BACKGROUND: To assess the techniques and materials used in intravitreal injections. DESIGN: Descriptive study realized at the Vision Institute of the Federal University of São Paulo, Brazil. SAMPLES: Different brands of needles and syringes, as well as enucleated porcine eyeballs. METHODS: The ultra-structures of commonly used needles were analysed by scanning electron microscope, and they were compared using different criteria, such as irregularities and debris from the lubrication process. The scleral incision was also assessed using needles of different brands and sizes. Accuracies in drug administration were studied by comparing the residual and delivered volume of needles and also by the analysis of reflux after intravitreal injections. MAIN OUTCOME MEASURES: Efficiency and quality of materials used in intravitreal injections. RESULTS: Ultra-structure analyses showed that all needles had different types of irregularities. Some photographs showed debris from the lubrication process, especially in BD needles. Scleral incision analysis showed a tendency of reducing the ocular damage with increasing gauge (P=0.024). The investigation of delivery accuracy showed that almost all needles underdosed the amount injected (P<0.05), and that the reflux could be minimized by tunnelled injections with thinner needles. CONCLUSION: Needles used in intravitreal injections possess many irregularities in their structures, which may cause different injection outcomes. Analyses of scleral incisions showed that the larger the needle gauge, the lesser the scleral damage and the risk of complications. Moreover, drug administration inaccuracies might be one of the causes for some unsuccessful attempts of treatment. SN - 1442-9071 UR - https://www.unboundmedicine.com/medline/citation/20973898/Experimental_investigation_of_needles_syringes_and_techniques_for_intravitreal_injections_ L2 - https://doi.org/10.1111/j.1442-9071.2010.02447.x DB - PRIME DP - Unbound Medicine ER -