Tags

Type your tag names separated by a space and hit enter

Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH.
Am J Surg Pathol 2010; 34(11):1630-6AJ

Abstract

In explant livers with chronic hepatitis C (HCV-C) we have noted a distinctive histologic variant that we have termed steatohepatitic hepatocellular carcinoma (SH-HCC) with features resembling non-neoplastic steatohepatitis, including large droplet steatosis, ballooning of malignant hepatocytes, Mallory-Denk bodies, inflammation, and pericellular fibrosis. This study was undertaken to further describe the characteristics and prevalence of this histologic variant in HCV-C and any possible association with underlying risk factors for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). We selected two 2-year periods (mid-2003 to mid-2005 and 2007 to 2008), from which selected explant livers with HCV-C and HCC were examined to determine the characteristics and frequency of SH-HCC. The underlying cirrhotic liver was also reassessed for steatosis and evidence of steatohepatitis. Clinical records were consulted for concomitant NAFLD and NASH risk factors. The SH-HCC variant was found in a total of 22 of 62 HCC cases (35.5%). Fourteen of the 22 patients with SH-HCC (63.6%) had at least one known risk factor for NAFLD/NASH including diabetes (6 of 22, 27.3%), obesity (6 of 22, 27.3%), hypertension (11 of 22, 50%), and hyperlipidemia (5 of 22, 27.8%). In 14 of the 22 cases (63.6%) of SH-HCC, the non-neoplastic liver showed changes of NAFLD/NASH superimposed on otherwise typical features of HCV-C. In conclusion, in our series of HCV-C explants, approximately one-third of HCCs show a distinctive histological variant termed SH-HCC. Underlying risk factors for NAFLD and for NASH were identified in 63.6% of our cases. Moreover, non-neoplastic tissue in HCV-C explants showed changes of NAFLD/NASH in 63.6% of cases. These results suggest a possible NAFLD/NASH pathway leading to SH-HCC in the setting of HCV-C which requires further investigation in the future.

Authors+Show Affiliations

Department of Pathology, Columbia University Medical Center, New York, NY 10032, USA. mas2300@columbia.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20975341

Citation

Salomao, Marcela, et al. "Steatohepatitic Hepatocellular Carcinoma (SH-HCC): a Distinctive Histological Variant of HCC in Hepatitis C Virus-related Cirrhosis With Associated NAFLD/NASH." The American Journal of Surgical Pathology, vol. 34, no. 11, 2010, pp. 1630-6.
Salomao M, Yu WM, Brown RS, et al. Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH. Am J Surg Pathol. 2010;34(11):1630-6.
Salomao, M., Yu, W. M., Brown, R. S., Emond, J. C., & Lefkowitch, J. H. (2010). Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH. The American Journal of Surgical Pathology, 34(11), pp. 1630-6. doi:10.1097/PAS.0b013e3181f31caa.
Salomao M, et al. Steatohepatitic Hepatocellular Carcinoma (SH-HCC): a Distinctive Histological Variant of HCC in Hepatitis C Virus-related Cirrhosis With Associated NAFLD/NASH. Am J Surg Pathol. 2010;34(11):1630-6. PubMed PMID: 20975341.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steatohepatitic hepatocellular carcinoma (SH-HCC): a distinctive histological variant of HCC in hepatitis C virus-related cirrhosis with associated NAFLD/NASH. AU - Salomao,Marcela, AU - Yu,Woojin M, AU - Brown,Robert S,Jr AU - Emond,Jean C, AU - Lefkowitch,Jay H, PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2010/11/16/medline SP - 1630 EP - 6 JF - The American journal of surgical pathology JO - Am. J. Surg. Pathol. VL - 34 IS - 11 N2 - In explant livers with chronic hepatitis C (HCV-C) we have noted a distinctive histologic variant that we have termed steatohepatitic hepatocellular carcinoma (SH-HCC) with features resembling non-neoplastic steatohepatitis, including large droplet steatosis, ballooning of malignant hepatocytes, Mallory-Denk bodies, inflammation, and pericellular fibrosis. This study was undertaken to further describe the characteristics and prevalence of this histologic variant in HCV-C and any possible association with underlying risk factors for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). We selected two 2-year periods (mid-2003 to mid-2005 and 2007 to 2008), from which selected explant livers with HCV-C and HCC were examined to determine the characteristics and frequency of SH-HCC. The underlying cirrhotic liver was also reassessed for steatosis and evidence of steatohepatitis. Clinical records were consulted for concomitant NAFLD and NASH risk factors. The SH-HCC variant was found in a total of 22 of 62 HCC cases (35.5%). Fourteen of the 22 patients with SH-HCC (63.6%) had at least one known risk factor for NAFLD/NASH including diabetes (6 of 22, 27.3%), obesity (6 of 22, 27.3%), hypertension (11 of 22, 50%), and hyperlipidemia (5 of 22, 27.8%). In 14 of the 22 cases (63.6%) of SH-HCC, the non-neoplastic liver showed changes of NAFLD/NASH superimposed on otherwise typical features of HCV-C. In conclusion, in our series of HCV-C explants, approximately one-third of HCCs show a distinctive histological variant termed SH-HCC. Underlying risk factors for NAFLD and for NASH were identified in 63.6% of our cases. Moreover, non-neoplastic tissue in HCV-C explants showed changes of NAFLD/NASH in 63.6% of cases. These results suggest a possible NAFLD/NASH pathway leading to SH-HCC in the setting of HCV-C which requires further investigation in the future. SN - 1532-0979 UR - https://www.unboundmedicine.com/medline/citation/20975341/Steatohepatitic_hepatocellular_carcinoma__SH_HCC_:_a_distinctive_histological_variant_of_HCC_in_hepatitis_C_virus_related_cirrhosis_with_associated_NAFLD/NASH_ L2 - http://dx.doi.org/10.1097/PAS.0b013e3181f31caa DB - PRIME DP - Unbound Medicine ER -