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211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice.
Pediatr Res. 2011 Feb; 69(2):170-4.PR

Abstract

Breastfeeding jaundice is a common problem in neonates who were exclusively breastfed, but its pathogenesis is still unclear. The uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphism was shown to contribute to the development of neonatal hyperbilirubinemia. We hypothesize that the variation of UGT1A1 gene may contribute to neonatal breastfeeding jaundice. We prospectively enrolled 688 near-term and term infants who were exclusively breastfed (BF group) or were supplemented by infant formula partially (SF group) before onset of hyperbilirubinemia. Genotyping of the promoter and exon1 of UGT1A1 was performed in all neonates. Neonates in BF group had a significantly higher maximal body weight loss ratio, peak bilirubin level, and a greater incidence of hyperbilirubinemia than those in SF group. Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG). This phenomenon was only seen in BF group but not in SF group when subset analysis was performed. This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice.

Authors+Show Affiliations

Departments of Pediatrics and Medical Genetics, Graduate Institute of Clinical Medicine, National Taiwan University Hospital, Taipei 100, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20975617

Citation

Chou, Hung-Chieh, et al. "211 G to a Variation of UDP-glucuronosyl Transferase 1A1 Gene and Neonatal Breastfeeding Jaundice." Pediatric Research, vol. 69, no. 2, 2011, pp. 170-4.
Chou HC, Chen MH, Yang HI, et al. 211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice. Pediatr Res. 2011;69(2):170-4.
Chou, H. C., Chen, M. H., Yang, H. I., Su, Y. N., Hsieh, W. S., Chen, C. Y., Chen, H. L., Chang, M. H., & Tsao, P. N. (2011). 211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice. Pediatric Research, 69(2), 170-4. https://doi.org/10.1203/PDR.0b013e31820263d2
Chou HC, et al. 211 G to a Variation of UDP-glucuronosyl Transferase 1A1 Gene and Neonatal Breastfeeding Jaundice. Pediatr Res. 2011;69(2):170-4. PubMed PMID: 20975617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 211 G to a variation of UDP-glucuronosyl transferase 1A1 gene and neonatal breastfeeding jaundice. AU - Chou,Hung-Chieh, AU - Chen,Mei-Huei, AU - Yang,Hwai-I, AU - Su,Yi-Ning, AU - Hsieh,Wu-Shiun, AU - Chen,Chien-Yi, AU - Chen,Huey-Ling, AU - Chang,Mei-Hwei, AU - Tsao,Po-Nien, PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2011/5/10/medline SP - 170 EP - 4 JF - Pediatric research JO - Pediatr. Res. VL - 69 IS - 2 N2 - Breastfeeding jaundice is a common problem in neonates who were exclusively breastfed, but its pathogenesis is still unclear. The uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphism was shown to contribute to the development of neonatal hyperbilirubinemia. We hypothesize that the variation of UGT1A1 gene may contribute to neonatal breastfeeding jaundice. We prospectively enrolled 688 near-term and term infants who were exclusively breastfed (BF group) or were supplemented by infant formula partially (SF group) before onset of hyperbilirubinemia. Genotyping of the promoter and exon1 of UGT1A1 was performed in all neonates. Neonates in BF group had a significantly higher maximal body weight loss ratio, peak bilirubin level, and a greater incidence of hyperbilirubinemia than those in SF group. Neonates with nucleotide 211 GA or AA variation in UGT1A1 genotypes had higher peak serum bilirubin levels and higher incidence of hyperbilirubinemia than WTs (GG). This phenomenon was only seen in BF group but not in SF group when subset analysis was performed. This suggests that neonates who carry the nucleotide 211 GA or AA variation within coding region in UGT1A1 gene are more susceptible to develop early-onset neonatal breastfeeding jaundice. SN - 1530-0447 UR - https://www.unboundmedicine.com/medline/citation/20975617/211_G_to_a_variation_of_UDP_glucuronosyl_transferase_1A1_gene_and_neonatal_breastfeeding_jaundice_ L2 - http://dx.doi.org/10.1203/PDR.0b013e31820263d2 DB - PRIME DP - Unbound Medicine ER -