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Lysine richness in human snurps - possible sites for electrophilic attacks.
Bioinformation 2010; 4(9):409-11B

Abstract

Gene-expression strategies are remodeled following exposure to stress. The reactive oxidants and electrophiles generated after stress actually affects the structural and functional properties of different cellular proteins. It is also seen that lysine rich motifs of proteins play crucial role in electrophilic attack and modification. Therefore, this study revealing lysine richness in 5 main human snrups (Small Nuclear Ribonucleoproteins) indicates a possible mechanism of gene regulation under stress. This possibility is highly supported by the findings that surface residues of the molecules were full of lysine rich clusters. Lysine richness is also found to be a highly conserved pattern across the various domains of life indicative of stress adaptation in the prebiotic to biotic world transition. Moreover the modeled structures showed good all atom contacts and minimal outliers.

Authors+Show Affiliations

DBT-Centre for Bioinformatics, Presidency College, Kolkata. sanjaydey23@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20975891

Citation

Dey, Sanjay Kumar, et al. "Lysine Richness in Human Snurps - Possible Sites for Electrophilic Attacks." Bioinformation, vol. 4, no. 9, 2010, pp. 409-11.
Dey SK, Ganguli S, Basu P, et al. Lysine richness in human snurps - possible sites for electrophilic attacks. Bioinformation. 2010;4(9):409-11.
Dey, S. K., Ganguli, S., Basu, P., Roy, P., & Datta, A. (2010). Lysine richness in human snurps - possible sites for electrophilic attacks. Bioinformation, 4(9), pp. 409-11.
Dey SK, et al. Lysine Richness in Human Snurps - Possible Sites for Electrophilic Attacks. Bioinformation. 2010 Mar 31;4(9):409-11. PubMed PMID: 20975891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lysine richness in human snurps - possible sites for electrophilic attacks. AU - Dey,Sanjay Kumar, AU - Ganguli,Sayak, AU - Basu,Protip, AU - Roy,Paushali, AU - Datta,Abhijit, Y1 - 2010/03/31/ PY - 2009/09/10/received PY - 2009/11/14/accepted PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2010/10/27/medline KW - Electrophiles KW - gene regulation KW - lysine KW - oxidative stress KW - snurps SP - 409 EP - 11 JF - Bioinformation JO - Bioinformation VL - 4 IS - 9 N2 - Gene-expression strategies are remodeled following exposure to stress. The reactive oxidants and electrophiles generated after stress actually affects the structural and functional properties of different cellular proteins. It is also seen that lysine rich motifs of proteins play crucial role in electrophilic attack and modification. Therefore, this study revealing lysine richness in 5 main human snrups (Small Nuclear Ribonucleoproteins) indicates a possible mechanism of gene regulation under stress. This possibility is highly supported by the findings that surface residues of the molecules were full of lysine rich clusters. Lysine richness is also found to be a highly conserved pattern across the various domains of life indicative of stress adaptation in the prebiotic to biotic world transition. Moreover the modeled structures showed good all atom contacts and minimal outliers. SN - 0973-2063 UR - https://www.unboundmedicine.com/medline/citation/20975891/Lysine_richness_in_human_snurps_-_possible_sites_for_electrophilic_attacks L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20975891/ DB - PRIME DP - Unbound Medicine ER -