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Association of serum 25-hydroxyvitamin D with the risk of death in a general older population in Finland.
Eur J Nutr. 2011 Aug; 50(5):305-12.EJ

Abstract

PURPOSE

To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentration, a marker of vitamin D status, and risk of all-cause and cardiovascular mortality in a general older population with relatively low average serum 25(OH)D concentrations.

METHODS

The study population included 552 men and 584 women aged 53-73 years who were free of CVD and cancer at baseline in 1998-2001 from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Deaths were ascertained by a computer linkage to the national cause of death register. All deaths that occurred from the study entry to December 31, 2008, were included. Cox proportional hazards regression models were used to analyze the association between serum 25(OH)D and risk of death.

RESULTS

The mean serum 25(OH)D concentration was 43.7 nmol/L (SD 17.8), with a strong seasonal variation. During the average follow-up of 9.1 years, 87 participants died, 35 from cardiovascular disease (CVD). After multivariable-adjustments, the hazard ratios (HR) for all cause death in the tertiles of serum 25(OH)D were 1, 1.68 (95% CI: 0.92, 3.07) and 2.06 (95% CI: 1.12, 3.80), p for trend = 0.02.

CONCLUSIONS

Our study supports the accumulating evidence from epidemiological studies that vitamin D deficiency is associated with increased risk of death. Large-scale primary prevention trials with vitamin D supplementation are warranted.

Authors+Show Affiliations

University of Eastern Finland, Kuopio Campus, Institute of Public Health and Clinical Nutrition, Finland. jyrki.virtanen@uef.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20976461

Citation

Virtanen, Jyrki K., et al. "Association of Serum 25-hydroxyvitamin D With the Risk of Death in a General Older Population in Finland." European Journal of Nutrition, vol. 50, no. 5, 2011, pp. 305-12.
Virtanen JK, Nurmi T, Voutilainen S, et al. Association of serum 25-hydroxyvitamin D with the risk of death in a general older population in Finland. Eur J Nutr. 2011;50(5):305-12.
Virtanen, J. K., Nurmi, T., Voutilainen, S., Mursu, J., & Tuomainen, T. P. (2011). Association of serum 25-hydroxyvitamin D with the risk of death in a general older population in Finland. European Journal of Nutrition, 50(5), 305-12. https://doi.org/10.1007/s00394-010-0138-3
Virtanen JK, et al. Association of Serum 25-hydroxyvitamin D With the Risk of Death in a General Older Population in Finland. Eur J Nutr. 2011;50(5):305-12. PubMed PMID: 20976461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of serum 25-hydroxyvitamin D with the risk of death in a general older population in Finland. AU - Virtanen,Jyrki K, AU - Nurmi,Tarja, AU - Voutilainen,Sari, AU - Mursu,Jaakko, AU - Tuomainen,Tomi-Pekka, Y1 - 2010/10/26/ PY - 2010/07/23/received PY - 2010/10/11/accepted PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2011/12/20/medline SP - 305 EP - 12 JF - European journal of nutrition JO - Eur J Nutr VL - 50 IS - 5 N2 - PURPOSE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] concentration, a marker of vitamin D status, and risk of all-cause and cardiovascular mortality in a general older population with relatively low average serum 25(OH)D concentrations. METHODS: The study population included 552 men and 584 women aged 53-73 years who were free of CVD and cancer at baseline in 1998-2001 from the prospective, population-based Kuopio Ischaemic Heart Disease Risk Factor (KIHD) Study. Deaths were ascertained by a computer linkage to the national cause of death register. All deaths that occurred from the study entry to December 31, 2008, were included. Cox proportional hazards regression models were used to analyze the association between serum 25(OH)D and risk of death. RESULTS: The mean serum 25(OH)D concentration was 43.7 nmol/L (SD 17.8), with a strong seasonal variation. During the average follow-up of 9.1 years, 87 participants died, 35 from cardiovascular disease (CVD). After multivariable-adjustments, the hazard ratios (HR) for all cause death in the tertiles of serum 25(OH)D were 1, 1.68 (95% CI: 0.92, 3.07) and 2.06 (95% CI: 1.12, 3.80), p for trend = 0.02. CONCLUSIONS: Our study supports the accumulating evidence from epidemiological studies that vitamin D deficiency is associated with increased risk of death. Large-scale primary prevention trials with vitamin D supplementation are warranted. SN - 1436-6215 UR - https://www.unboundmedicine.com/medline/citation/20976461/Association_of_serum_25_hydroxyvitamin_D_with_the_risk_of_death_in_a_general_older_population_in_Finland_ L2 - https://dx.doi.org/10.1007/s00394-010-0138-3 DB - PRIME DP - Unbound Medicine ER -