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Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease.
Mov Disord. 2010 Oct 30; 25(14):2296-303.MD

Abstract

The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD.

Authors+Show Affiliations

Clinical Research Department, The Parkinson's Institute and Clinical Center, Sunnyvale, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20976736

Citation

Valappil, Ruksana Azhu, et al. "Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 25, no. 14, 2010, pp. 2296-303.
Valappil RA, Black JE, Broderick MJ, et al. Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease. Mov Disord. 2010;25(14):2296-303.
Valappil, R. A., Black, J. E., Broderick, M. J., Carrillo, O., Frenette, E., Sullivan, S. S., Goldman, S. M., Tanner, C. M., & Langston, J. W. (2010). Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 25(14), 2296-303. https://doi.org/10.1002/mds.23348
Valappil RA, et al. Exploring the Electrocardiogram as a Potential Tool to Screen for Premotor Parkinson's Disease. Mov Disord. 2010 Oct 30;25(14):2296-303. PubMed PMID: 20976736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease. AU - Valappil,Ruksana Azhu, AU - Black,Jed E, AU - Broderick,Meredith J, AU - Carrillo,Oscar, AU - Frenette,Eric, AU - Sullivan,Shannon S, AU - Goldman,Samuel M, AU - Tanner,Caroline M, AU - Langston,James W, PY - 2010/10/27/entrez PY - 2010/10/27/pubmed PY - 2011/2/23/medline SP - 2296 EP - 303 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 25 IS - 14 N2 - The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age-matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5-minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R-R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R-R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, P = 0.016). Leave-one-out cross-validation correctly classified 77.3% of subjects. HRV during wakefulness is significantly decreased in patients with idiopathic REM sleep behavior disorder compared with control subjects, suggesting abnormalities of both sympathetic and parasympathetic function. Patients with RBD may later develop motor and cognitive features of a Lewy body disorder, such as PD. Cardiac autonomic dysfunction is also impaired in PD, suggesting that impaired HRV may be an early sign of PD. HRV measured by routine electrocardiograms could be used to screen for Lewy body disorders such as PD. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/20976736/Exploring_the_electrocardiogram_as_a_potential_tool_to_screen_for_premotor_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -