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Effect of regular physical activity on carotid intima-media thickness. Results from a 6-year prospective study in the early stage of hypertension.
Blood Press 2011; 20(1):37-44BP

Abstract

AIM

To study the effect of leisure-time physical activity on the progression of carotid intima-media thickness (IMT) in the early stage of hypertension.

METHODS

We studied 47 sedentary and 40 physically active young pre-hypertensive or stage 1 hypertensive subjects. IMT was assessed in the common carotid artery, carotid bulb and internal carotid artery at baseline and after 6.5 years.

RESULTS

Cumulative maximum IMT of the three carotid segments (M-MAX, 0.13 ± 0.08 vs 0.10 ± 0.07 mm, p = 0.006) and cumulative mean IMT (m-IMT, 0.11 ± 0.07 vs 0.09 ± 0.06 mm, p = 0.01), adjusted for confounders, increased to a greater degree in the sedentary than the active subjects. Differences in known risk factors explained a large proportion of the observed association. Inclusion of baseline cholesterol in the regression model attenuated the strength of the association for both M-MAX (p = 0.04) and m-IMT (p = 0.049). When also baseline blood pressure, heart rate, and body mass index were taken into account the association with physical activity status remained significant for maximum IMT of internal carotid artery (p = 0.034) and was of borderline significance for M-MAX (p = 0.066).

CONCLUSIONS

Physical activity can delay the progression of carotid IMT in hypertension. This effect is mediated in substantial part by the better risk factor profile in active subjects.

Authors+Show Affiliations

Dipartimento di Medicina Clinica e Sperimentale, Università di Padova, Via Giustiniani 2, Padua, Italy. palatini@unipd.itNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20977389

Citation

Palatini, Paolo, et al. "Effect of Regular Physical Activity On Carotid Intima-media Thickness. Results From a 6-year Prospective Study in the Early Stage of Hypertension." Blood Pressure, vol. 20, no. 1, 2011, pp. 37-44.
Palatini P, Puato M, Rattazzi M, et al. Effect of regular physical activity on carotid intima-media thickness. Results from a 6-year prospective study in the early stage of hypertension. Blood Press. 2011;20(1):37-44.
Palatini, P., Puato, M., Rattazzi, M., & Pauletto, P. (2011). Effect of regular physical activity on carotid intima-media thickness. Results from a 6-year prospective study in the early stage of hypertension. Blood Pressure, 20(1), pp. 37-44. doi:10.3109/08037051.2010.524080.
Palatini P, et al. Effect of Regular Physical Activity On Carotid Intima-media Thickness. Results From a 6-year Prospective Study in the Early Stage of Hypertension. Blood Press. 2011;20(1):37-44. PubMed PMID: 20977389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of regular physical activity on carotid intima-media thickness. Results from a 6-year prospective study in the early stage of hypertension. AU - Palatini,Paolo, AU - Puato,Massimo, AU - Rattazzi,Marcello, AU - Pauletto,Paolo, Y1 - 2010/10/27/ PY - 2010/10/28/entrez PY - 2010/10/28/pubmed PY - 2011/6/1/medline SP - 37 EP - 44 JF - Blood pressure JO - Blood Press. VL - 20 IS - 1 N2 - AIM: To study the effect of leisure-time physical activity on the progression of carotid intima-media thickness (IMT) in the early stage of hypertension. METHODS: We studied 47 sedentary and 40 physically active young pre-hypertensive or stage 1 hypertensive subjects. IMT was assessed in the common carotid artery, carotid bulb and internal carotid artery at baseline and after 6.5 years. RESULTS: Cumulative maximum IMT of the three carotid segments (M-MAX, 0.13 ± 0.08 vs 0.10 ± 0.07 mm, p = 0.006) and cumulative mean IMT (m-IMT, 0.11 ± 0.07 vs 0.09 ± 0.06 mm, p = 0.01), adjusted for confounders, increased to a greater degree in the sedentary than the active subjects. Differences in known risk factors explained a large proportion of the observed association. Inclusion of baseline cholesterol in the regression model attenuated the strength of the association for both M-MAX (p = 0.04) and m-IMT (p = 0.049). When also baseline blood pressure, heart rate, and body mass index were taken into account the association with physical activity status remained significant for maximum IMT of internal carotid artery (p = 0.034) and was of borderline significance for M-MAX (p = 0.066). CONCLUSIONS: Physical activity can delay the progression of carotid IMT in hypertension. This effect is mediated in substantial part by the better risk factor profile in active subjects. SN - 1651-1999 UR - https://www.unboundmedicine.com/medline/citation/20977389/Effect_of_regular_physical_activity_on_carotid_intima_media_thickness__Results_from_a_6_year_prospective_study_in_the_early_stage_of_hypertension_ L2 - http://www.tandfonline.com/doi/full/10.3109/08037051.2010.524080 DB - PRIME DP - Unbound Medicine ER -